INT98603

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Context Info
Confidence 0.15
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.59
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 3
internal 1
Cnnm3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 3 90.64 High High
antagonist 6 90.24 High High
substance P 2 89.92 High High
adenocard 1 84.48 Quite High
qutenza 89 84.24 Quite High
Kinase C 42 73.56 Quite High
Spinal cord 8 50.00 Quite Low
medulla 8 50.00 Quite Low
Morphine 8 50.00 Quite Low
TRP channel 10 17.28 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 97.60 Very High Very High Very High
Rupture 2 53.72 Quite High
Ganglion Cysts 56 5.16 Low Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Gene_expression (levels) of m3 in spinal cord
1) Confidence 0.15 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Gene_expression (levels) of m3 in spinal cord
2) Confidence 0.15 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Gene_expression (levels) of m3 in spinal cord
3) Confidence 0.13 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for CGRP1 receptors, muscarinic m2, m3 and m5 receptors and neurokinin1 (NK1) and NK3, receptors was detected.
Gene_expression (Expression) of m3
4) Confidence 0.09 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11593767 Disease Relevance 0.53 Pain Relevance 0.43
METHODS: The mRNA expression level of m1, m2, m3, m4 and m5 were determined by RT-PCR, the beta-actin mRNA expression was used as internal control.
Gene_expression (expression) of m3 in internal
5) Confidence 0.07 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
In HEK 293 cells over-expressing M3, a G?
Gene_expression (expressing) of M3
6) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.05 Pain Relevance 0.10
However, in HEK 293 cells expressing both M3 and TRPV1, acetylcholine induced significant inward currents even in the presence of both 1 ?
Gene_expression (expressing) of M3
7) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.15

General Comments

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