INT98641

Context Info Confidence 0.23 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 2.89 Pain Relevance 0.17

Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Anatomy Link Frequency fibroblast 2 Phex (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 2 86.68

Disease Link Frequency Relevance Heat Autosomal Disorder 2 96.72 Rickets 12 95.44 Cancer 4 93.76 Neurilemmoma 4 89.88 Malignant Neoplastic Disease 4 89.44 Muscle Weakness 2 87.88 Fatigue 2 87.04 Pain 2 86.68 Hypophosphatemia 2 82.68 Paraneoplastic Syndromes 2 80.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.

Transcription (transcripts) of endopeptidases in fibroblast associated with autosomal disorder and rickets

1) Confidence 0.23 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.44 Pain Relevance 0.08

The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.

Transcription (transcripts) of PHEX in fibroblast associated with autosomal disorder and rickets

2) Confidence 0.20 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.46 Pain Relevance 0.09

General Comments

This test has worked.