INT98645

Context Info Confidence 0.78 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 10.07 Pain Relevance 0.80

cell differentiation (FGF23) extracellular space (FGF23) extracellular region (FGF23)

Anatomy Link Frequency fibroblast 5 proximal 1 FGF23 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 11 90.36 imagery 6 48.48

Disease Link Frequency Relevance Heat Cancer 31 99.98 Rickets 49 99.68 Malignant Neoplastic Disease 6 99.56 Hypophosphatemia 12 99.28 Neurilemmoma 6 99.16 Paraneoplastic Syndromes 3 97.36 Autosomal Disorder 3 96.20 Pain 9 90.36 Fatigue 5 90.12 Muscle Weakness 3 89.60

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Disease term

Oncogenic osteomalacia (OOM) is characterised by tumour production of fibroblast growth factor 23 (FGF23) that results in hypophosphataemia and renal phosphate wasting, reduced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and osteomalacia.

Gene_expression (production) of fibroblast growth factor 23 in fibroblast associated with cancer, rickets and hypophosphatemia

1) Confidence 0.78 Published 2008 Journal Eur. J. Endocrinol. Section Abstract Doc Link 18230836 Disease Relevance 0.84 Pain Relevance 0.07

Oncogenic osteomalacia (OOM) is characterised by tumour production of fibroblast growth factor 23 (FGF23) that results in hypophosphataemia and renal phosphate wasting, reduced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and osteomalacia.

Gene_expression (production) of FGF23 in fibroblast associated with cancer, rickets and hypophosphatemia

2) Confidence 0.78 Published 2008 Journal Eur. J. Endocrinol. Section Abstract Doc Link 18230836 Disease Relevance 0.84 Pain Relevance 0.07

The expression of FGF23 was demonstrated in the tumor by the immunohistochemical techniques and a Western analysis.

Gene_expression (expression) of FGF23 associated with cancer

3) Confidence 0.77 Published 2006 Journal Am. J. Med. Sci. Section Abstract Doc Link 16969146 Disease Relevance 0.96 Pain Relevance 0.07

These results confirm the importance of this site in FGF23 function and its essential role in ADHR physiopathology.

Gene_expression (function) of FGF23 associated with rickets

4) Confidence 0.67 Published 2010 Journal J. Bone Miner. Metab. Section Abstract Doc Link 19655082 Disease Relevance 1.01 Pain Relevance 0.07

The pathogenesis of tumor-induced osteomalacia involves tumor expression of fibroblast growth factor 23, a hormone that inhibits proximal renal tubular reabsorption of phosphate and down-regulates renal conversion of 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D.

Gene_expression (expression) of factor 23 in proximal associated with rickets and cancer

5) Confidence 0.58 Published 2008 Journal Arthritis Rheum. Section Abstract Doc Link 18311810 Disease Relevance 1.20 Pain Relevance 0.08

HMS-97 cells might be useful for further studies that aim to determine the genetic mechanism that leads to the observed PHEX and FGF-23 expression, both of which might have a direct role in the pathogenesis of oncogenic osteomalacia.

Gene_expression (expression) of FGF-23 associated with rickets

6) Confidence 0.46 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.24 Pain Relevance 0.06

A case of neuroendocrine oncogenic osteomalacia associated with a PHEX and fibroblast growth factor-23 expressing sinusidal malignant schwannoma.

Gene_expression (expressing) of fibroblast growth factor-23 in fibroblast associated with malignant neoplastic disease, rickets and neurilemmoma

7) Confidence 0.46 Published 2001 Journal Bone Section Title Doc Link 11595624 Disease Relevance 1.47 Pain Relevance 0.09

The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.

Gene_expression (express) of fibroblast growth factor-23 in fibroblast associated with autosomal disorder and rickets

8) Confidence 0.36 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.46 Pain Relevance 0.09

The most extensively studied phosphatonin to date is fibroblast growth factor 23 (FGF23), which was first identified in patients with tumor-induced osteomalacia and shown to be secreted by the neoplastic cells.

Gene_expression (identified) of fibroblast growth factor 23 in fibroblast associated with rickets and cancer

9) Confidence 0.17 Published 2005 Journal Joint Bone Spine Section Abstract Doc Link 16214071 Disease Relevance 1.05 Pain Relevance 0.20

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