INT98984

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.51
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE3)
Anatomy Link Frequency
eosinophil 2
bone marrow 1
RNASE3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 100.00 Very High Very High Very High
chemokine 5 100.00 Very High Very High Very High
Inflammatory mediators 3 100.00 Very High Very High Very High
Inflammation 92 98.56 Very High Very High Very High
dexamethasone 21 98.52 Very High Very High Very High
Inflammatory marker 2 84.48 Quite High
Inflammatory response 3 79.72 Quite High
local anesthetic 1 74.72 Quite High
spastic colon 25 65.36 Quite High
antagonist 2 47.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Rhinitis 79 100.00 Very High Very High Very High
Hypersensitivity 29 99.60 Very High Very High Very High
Adhesions 25 99.56 Very High Very High Very High
Inflammatory Bowel Disease 123 98.80 Very High Very High Very High
Mucositis 9 98.24 Very High Very High Very High
Recurrence 10 93.24 High High
Urological Neuroanatomy 3 86.16 High High
Death 1 83.64 Quite High
Gastroenteritis 15 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucosal inflammation symptoms correlated with increased levels of albumin, but not with increased levels of ECP, secreted proinflammatory cytokines or cytokine gene mRNA expression.
Localization (secreted) of ECP associated with mucositis, inflammation and cytokine
1) Confidence 0.47 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.54 Pain Relevance 0.46
-induced ECP release and their adhesion to immobilised VCAM-1, ICAM-1 and IgG.
Localization (release) of ECP associated with adhesions
2) Confidence 0.11 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.51 Pain Relevance 0.43
Eosinophil infiltration is accompanied by degranulation and the release of a plethora of mediators, including cytokines, chemokines, major basic protein, eosinophilic cationic protein and lipid mediators, further accentuating the damage to gastric tissue [37].
Localization (release) of cationic protein in Eosinophil associated with chemokine, rhinitis and cytokine
3) Confidence 0.06 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 1.05 Pain Relevance 0.26
Eosinophil protein X (EPX) is released by activated eosinophil granulocytes, which are abundant in the mucosa in active IBD.67 Fecal EPX levels are mainly studied as an indicator of the treatment outcome in relapses of IBD.
Localization (released) of Eosinophil protein X in eosinophil associated with inflammatory bowel disease and recurrence
4) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.17 Pain Relevance 0.15
Eosinophils are the predominant cell type in the chronic inflammatory processes that characterize the late-phase allergic response, and they release a broad array of pro-inflammatory mediators, including cysteinyl leukotrienes, ECP, eosinophil peroxidase, and major basic protein.15,20 These cells may also serve as a major source of IL-3, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-13.20 IL-5 is an eosinopoietic cytokine that promotes eosinophil differentiation and maturation within the bone marrow.27 Circulating eosinophils are increased in number in subjects with allergic disorders, and infiltration at the site of provocation has been generally attributed to influx of mature cells.
Localization (release) of ECP in bone marrow associated with inflammatory mediators, inflammation, hypersensitivity and cytokine
5) Confidence 0.02 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866558 Disease Relevance 1.12 Pain Relevance 0.38

General Comments

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