INT98989

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.69
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL18R1) plasma membrane (IL18R1) intracellular (IL18R1)
Anatomy Link Frequency
macrophage 1
nerve 1
astrocytes 1
microglia 1
IL18R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
spinal dorsal horn 3 99.84 Very High Very High Very High
Dorsal horn 3 99.68 Very High Very High Very High
Inflammation 6 98.64 Very High Very High Very High
Brush evoked pain 9 98.40 Very High Very High Very High
Inflammatory marker 1 85.28 High High
intrathecal 3 77.04 Quite High
local anesthetic 1 75.52 Quite High
Spinal cord 6 75.00 Quite High
Neuropathic pain 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Mucositis 1 98.64 Very High Very High Very High
Neuropathic Pain 15 98.40 Very High Very High Very High
Nervous System Injury 12 98.12 Very High Very High Very High
Injury 6 90.32 High High
INFLAMMATION 3 84.96 Quite High
Necrosis 1 81.88 Quite High
Cancer 1 81.52 Quite High
Hypersensitivity 2 72.60 Quite High
Dysmenorrhea 2 62.92 Quite High
Post Operative Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In the microarray analysis of hip drain neutrophils, interleukin-1 receptor antagonist (IL1RN), interleukin-18 receptor 1 (IL18R1), macrophage migration inhibitory factor (MIF), and macrophage inflammatory protein 3alpha (CCL20) were upregulated, whereas interleukin-8 receptor beta (IL8RB/CXCR2) was consistently downregulated, compared with presurgery blood neutrophils.
Positive_regulation (upregulated) of IL18R1 in macrophage
1) Confidence 0.47 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.07 Pain Relevance 0
Quantitative competitive PCR demonstrated that endometrial IL-18R mRNA and the ratio of IL-18BP to IL-18 were significantly increased in adenomyosis patients in comparison to the control group.
Positive_regulation (increased) of IL-18R
2) Confidence 0.13 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.06 Pain Relevance 0
Here we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal horn, are crucial for tactile allodynia after nerve injury.
Positive_regulation (induced) of IL-18R in nerve associated with brush evoked pain, nervous system injury and spinal dorsal horn
3) Confidence 0.05 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.64 Pain Relevance 0.41
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (upregulated) of IL-18R in astrocytes associated with nervous system injury and dorsal horn
4) Confidence 0.05 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.69 Pain Relevance 0.52
Mucosal inflammation symptoms correlated with increased levels of albumin, but not with increased levels of ECP, secreted proinflammatory cytokines or cytokine gene mRNA expression.
Neg (not) Positive_regulation (increased) of cytokine gene mRNA associated with mucositis, inflammation and cytokine
5) Confidence 0.03 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.55 Pain Relevance 0.47
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (upregulated) of IL-18R in microglia associated with nervous system injury and dorsal horn
6) Confidence 0.02 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.69 Pain Relevance 0.52

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