INT9900

Context Info Confidence 0.69 First Reported 1986 Last Reported 2011 Negated 1 Speculated 3 Reported most in Abstract Documents 80 Total Number 83 Disease Relevance 51.85 Pain Relevance 18.13

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf) proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)

Anatomy Link Frequency platelet 14 plasma 8 coronary artery 3 leukocyte 3 blood 2 Vwf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Angina 170 100.00 corticosteroid 10 100.00 cytokine 4 100.00 withdrawal 5 99.98 Migraine 27 99.84 ischemia 66 99.72 rheumatoid arthritis 178 99.48 aspirin 129 98.56 metalloproteinase 1 98.20 cva 13 98.10

Disease Link Frequency Relevance Heat Cv General 3 Under Development 153 100.00 Thrombophilia 3 99.96 Myocardial Infarction 147 99.90 Skin Cancer 47 99.90 Coronary Artery Disease 72 99.84 Headache 30 99.84 Cancer 87 99.78 Cv Unclassified Under Development 42 99.72 Syndrome 81 99.56 Complex Regional Pain Syndromes 3 99.54

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other evidence of vascular perturbation in migraine comes from studies showing elevated von Willebrand factor (vWF).

Positive_regulation (elevated) of von Willebrand factor associated with migraine

1) Confidence 0.69 Published 2007 Journal Thromb. Res. Section Abstract Doc Link 16504253 Disease Relevance 0.65 Pain Relevance 0.19

Other evidence of vascular perturbation in migraine comes from studies showing elevated von Willebrand factor (vWF).

Positive_regulation (elevated) of vWF associated with migraine

2) Confidence 0.69 Published 2007 Journal Thromb. Res. Section Abstract Doc Link 16504253 Disease Relevance 0.65 Pain Relevance 0.19

Desmopressin was administered preoperatively to increase platelet aggregation and the von Willebrand factor level.

Positive_regulation (increase) of von Willebrand factor in platelet

3) Confidence 0.68 Published 2007 Journal AANA J Section Abstract Doc Link 17711156 Disease Relevance 1.21 Pain Relevance 0.32

Increased von Willebrand factor in migraine.

Positive_regulation (Increased) of von Willebrand factor associated with migraine

4) Confidence 0.66 Published 2001 Journal Neurology Section Title Doc Link 11468324 Disease Relevance 0.74 Pain Relevance 0.47

Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction.

Positive_regulation (induced) of von Willebrand factor in platelets associated with myocardial infarction

5) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Title Doc Link 11113268 Disease Relevance 0.55 Pain Relevance 0.09

Recent studies have demonstrated elevations of von Willebrand Factor following acute myocardial infarction (AMI).

Positive_regulation (elevations) of von Willebrand Factor associated with myocardial infarction

6) Confidence 0.66 Published 1986 Journal Thromb. Haemost. Section Abstract Doc Link 3092393 Disease Relevance 0.82 Pain Relevance 0.24

No significant elevation of vWF was observed in patients with unstable angina.

Neg (No) Positive_regulation (elevation) of vWF associated with angina

7) Confidence 0.66 Published 1986 Journal Thromb. Haemost. Section Abstract Doc Link 3092393 Disease Relevance 0.95 Pain Relevance 0.33

During the nocturnal ischemia periods, the increase in vWf levels immediately after angina was significantly more apparent than the detected changes during daytime ischemia.

Positive_regulation (increase) of vWf associated with angina and ischemia

8) Confidence 0.65 Published 2003 Journal Angiology Section Abstract Doc Link 12785021 Disease Relevance 2.05 Pain Relevance 1.25

Experimental data documented that an increase of cytokine and von Willebrand factor (vWF) levels in unstable angina (UA) and non-Q wave myocardial infarction (MI) predicts an adverse outcome.

Positive_regulation (increase) of vWF associated with angina, myocardial infarction and cytokine

9) Confidence 0.52 Published 2004 Journal Kardiol Pol Section Abstract Doc Link 15457277 Disease Relevance 0.88 Pain Relevance 0.33

Experimental data documented that an increase of cytokine and von Willebrand factor (vWF) levels in unstable angina (UA) and non-Q wave myocardial infarction (MI) predicts an adverse outcome.

Positive_regulation (increase) of von Willebrand factor associated with angina, myocardial infarction and cytokine

10) Confidence 0.52 Published 2004 Journal Kardiol Pol Section Abstract Doc Link 15457277 Disease Relevance 0.88 Pain Relevance 0.32

Multivariate analysis identified increased plasma levels of von Willebrand factor (vWF) and decreased platelet levels of glycoprotein Ib/IX complexes as independent predictors of 1-month adverse outcome (a composite of death, myocardial infarction, and recurrent ischemia). vWF release was strongly related to and may have been released by inflammation as measured by C-reactive protein.

Positive_regulation (increased) of vWF in platelet associated with inflammation, ischemia, myocardial infarction and death

11) Confidence 0.52 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12686329 Disease Relevance 0.99 Pain Relevance 0.56

Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction.

Positive_regulation (Enhanced) of von Willebrand factor in platelets associated with myocardial infarction

12) Confidence 0.48 Published 2000 Journal Thromb. Res. Section Title Doc Link 11113268 Disease Relevance 0.55 Pain Relevance 0.09

We hypothesized that the concentrations of hs-CRP and vWF are substantially increased in patients with unstable angina pectoris (UAP) and noticeably decreased following coronary stenting along with atorvastatin therapy.

Positive_regulation (increased) of vWF associated with angina

13) Confidence 0.48 Published 2006 Journal International heart journal Section Abstract Doc Link 16960405 Disease Relevance 0.44 Pain Relevance 0.49

BACKGROUND: The early increase of vWf has been reported to be a risk factor for adverse outcome in unstable angina.

Positive_regulation (increase) of vWf

14) Confidence 0.46 Published 2000 Journal J. Am. Coll. Cardiol. Section Body Doc Link 10898421 Disease Relevance 0.10 Pain Relevance 0

Increased levels of plasma von Willebrand factor in migraine crisis.

Positive_regulation (Increased) of von Willebrand factor in plasma associated with migraine

15) Confidence 0.46 Published 1995 Journal Acta Neurol. Scand. Section Title Doc Link 7639074 Disease Relevance 0.20 Pain Relevance 0.20

The effects of plasma obtained from 15 patients with acute myocardial infarction and 10 patients with the chest pain syndrome as controls, on shear-induced vWF binding to platelets and subsequent platelet activation, as evidenced by microparticle release, were investigated by quantitative flow cytometry.

Spec (investigated) Positive_regulation (induced) of vWF in plasma associated with complex regional pain syndromes, angina and myocardial infarction

16) Confidence 0.44 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.44 Pain Relevance 0.10

At the 6 PM to 10 PM period, the vWf level increase was significantly higher in patients with TMI than in the patients without TMI.

Positive_regulation (increase) of vWf associated with ischemia

17) Confidence 0.44 Published 2003 Journal Angiology Section Abstract Doc Link 12785021 Disease Relevance 1.83 Pain Relevance 1.12

The study confirms that the vWf level, which is an indicator of thrombogenesis, was significantly increased in patients with ACS.

Positive_regulation (increased) of vWf associated with acute coronary syndrome

18) Confidence 0.44 Published 2003 Journal Angiology Section Abstract Doc Link 12785021 Disease Relevance 1.77 Pain Relevance 1.07

Re-elevation of high-sensitivity C-reactive protein but not the von Willebrand Factor after withdrawing atorvastatin therapy in patients with unstable angina undergoing coronary artery stenting.

Positive_regulation (elevation) of von Willebrand Factor in coronary artery associated with angina

19) Confidence 0.42 Published 2006 Journal International heart journal Section Title Doc Link 16960405 Disease Relevance 0.40 Pain Relevance 0.45

In dalteparin-treated patients, delta vWf was elevated (+48 +/- 8%) and did not differ from the unfractionated heparin group (NS).

Positive_regulation (elevated) of vWf

20) Confidence 0.40 Published 2000 Journal J. Am. Coll. Cardiol. Section Body Doc Link 10898421 Disease Relevance 0 Pain Relevance 0

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