INT99020

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 18.86
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Anatomy Link Frequency
muscle 1
pituitary 1
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 984 99.54 Very High Very High Very High
Central nervous system 1 98.88 Very High Very High Very High
Inflammation 388 97.00 Very High Very High Very High
Sciatica 33 95.24 Very High Very High Very High
Inflammatory stimuli 1 92.76 High High
cytokine 71 86.40 High High
anakinra 28 85.60 High High
antagonist 7 84.72 Quite High
chemokine 22 84.04 Quite High
Inflammatory response 26 80.08 Quite High
Disease Link Frequency Relevance Heat
Syndrome 22 100.00 Very High Very High Very High
Inflammatory Bowel Disease 1430 99.80 Very High Very High Very High
Disease 1193 99.54 Very High Very High Very High
Crystal Associated Disease 230 98.46 Very High Very High Very High
Infection 89 98.44 Very High Very High Very High
Plasmodium Infection 34 98.24 Very High Very High Very High
INFLAMMATION 385 97.00 Very High Very High Very High
Nerve Root Compression 41 95.60 Very High Very High Very High
Brachial Plexus Neuropathies 4 94.52 High High
Fever 180 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both gene products of NOD2 and NLRP3 play central roles in intracellular bacterial sensing and the CD associated variants of both genes were reported to result in a loss-of-function phenotype characterized by a decrease in secretion of IL-1?
Gene_expression (products) of NLRP3 associated with crohn's disease
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.18 Pain Relevance 0.35
The aim of this study was to report a novel NLRP3 mutation in 2 siblings of Swedish descent in whom symptoms first presented in adulthood.
Gene_expression (mutation) of NLRP3
2) Confidence 0.65 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?
Gene_expression (/) of cryopyrin
3) Confidence 0.65 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.02 Pain Relevance 0.26
Also, given that common variants in the NLRP3 region have previously been associated with CD [3] and that the gene products of NLRP3 and MEFV (i.e.
Gene_expression (products) of NLRP3 associated with crohn's disease
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.19 Pain Relevance 0.49
To assess this latter possibility, since we knew that the MEFV and the NLRP3 gene product interacted with each other, we genotyped the six SNPs in the NLRP3 region that had been previously associated with CD [3] in both the Belgian and Canadian UC sample sets and performed gene-gene interaction analysis using these six NLRP3 SNPs and the 16 SNPs genotyped in the MEFV region (i.e. 12 tagging SNPs and 4 coding SNPs in MEFV exon 2 region).
Gene_expression (product) of NLRP3 associated with inflammatory bowel disease and crohn's disease
5) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.26 Pain Relevance 0.05
Also, given that common variants in the NLRP3 region have previously been associated with CD [3] and that the gene products of NLRP3 and MEFV (i.e.
Gene_expression (region) of NLRP3 associated with crohn's disease
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.25 Pain Relevance 0.49
As no significant interactions were observed between NLRP3 variants and rs224222, the basis behind the inverse allele associations observed with rs224222 remains unresolved.
Gene_expression (variants) of NLRP3
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.29 Pain Relevance 0.04
Based on the identification of six common SNPs in the NLRP3 region contributing to CD susceptibility [3] and reports that the NLRP3 and MEFV gene products interact with each other and are involved in similar pathways, we sought to evaluate whether possible gene-gene interaction between the MEFV tagging SNPs and the NLRP3 six common SNPs could have masked an MEFV contribution to CD susceptibility.
Gene_expression (products) of NLRP3 associated with crohn's disease
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.98 Pain Relevance 0.26
The group of Tschopp discovered that many inorganic particles, including MSU and calcium pyrophosphate dihydrate crystals, are capable of activating the NLRP3 inflammasome to process and secrete active IL-1?
Gene_expression (process) of NLRP3 associated with crystal associated disease
9) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.44 Pain Relevance 0.03
On assembly of the inflammasome, which consists of a member of the nucleotide-binding oligomerization domain-leucine rich repeat protein family (such as NALP1, NALP2, NALP3, or IPAF), the adaptor protein ASC and caspase-1 [7], caspase-1 becomes active and cleaves pro-IL-1?
Gene_expression (family) of NALP3
10) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.79 Pain Relevance 0.31
Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome.
Gene_expression (product) of NLRP3
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2745755 Disease Relevance 1.13 Pain Relevance 0.19
This clinical and epidemiological evidence linking IBD to the MEFV gene, together with the co-localization of the MEFV and NLRP3 gene products (pyrin and NALP3, respectively) within the same signaling pathway, suggested that MEFV could also contribute to CD and/or UC susceptibility.
Gene_expression (products) of NALP3 associated with inflammatory bowel disease and crohn's disease
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.83 Pain Relevance 0.17
Interestingly, as is the case for the NOD2 mutations associated uniquely to CD [37], no associations between the NLRP3 variants and UC were observed.
Gene_expression (variants) of NLRP3 associated with inflammatory bowel disease and crohn's disease
13) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.16 Pain Relevance 0.28
No epistatic interactions are observed between NLRP3 and MEFV in the CD and UC combined Belgian-Canadian sample set
Neg (No) Gene_expression (observed) of NLRP3 associated with inflammatory bowel disease and crohn's disease
14) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.03 Pain Relevance 0.23
was significantly lower in NLRP3-deficient mouse in comparison with wild type mice (Fig. 3G) and was not detectable in IL-1?
Gene_expression (lower) of NLRP3
15) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.92 Pain Relevance 0.09
and the NLRP3 inflammasome during malarial disease we infected IL-1?
Gene_expression (inflammasome) of NLRP3 associated with disease
16) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.78 Pain Relevance 0.15
The identification of the NALP-3 mutations as well as the demonstration that, in patients with Muckle-Wells syndrome, IL-1?
Gene_expression (syndrome) of NALP-3 associated with syndrome
17) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.89 Pain Relevance 0.18
The C7 myotome in the FCU is relatively common, and needle EMG of this muscle may provide more information for the electrodiagnosis of cervical radiculopathy and brachial plexopathy.



Gene_expression (myotome) of FCU in muscle associated with brachial plexus neuropathies, nerve root compression and sciatica
18) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826750 Disease Relevance 0.50 Pain Relevance 0.26
To date, four different inflammasomes have been characterized [34], containing the Nod-like receptors (NLR): Nalp1, Nalp2, Nalp3 and Ipaf.
Gene_expression (containing) of Nalp3
19) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.09 Pain Relevance 0.15
For 15 C. trachomatis positive women, C. trachomatis was detected in either FCU (seven women) or the cervical swab (eight women) by the SDA method.
Gene_expression (detected) of FCU
20) Confidence 0.29 Published 2010 Journal BMC Womens Health Section Body Doc Link PMC2861009 Disease Relevance 0.50 Pain Relevance 0

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