INT99149

Context Info Confidence 0.36 First Reported 2000 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 5 Disease Relevance 3.29 Pain Relevance 0.93

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1) plasma membrane (VCAM1)

Anatomy Link Frequency muscle 1 VCAM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Infliximab 2 98.64 Inflammation 60 97.68 rheumatoid arthritis 107 96.36 Analgesic 1 94.80 Arthritis 39 92.12 cytokine 55 84.60 Bioavailability 1 63.68 antagonist 10 24.64 chemokine 5 15.52 psoriasis 1 14.40

Disease Link Frequency Relevance Heat Adhesions 17 100.00 INFLAMMATION 60 97.68 Rheumatoid Arthritis 112 96.36 Disease Progression 12 95.16 Apoptosis 8 93.60 Acute Disease 3 91.68 Muscular Dystrophy 70 90.16 Increased Venous Pressure Under Development 11 86.56 Arthritis 36 84.56 Disease 46 82.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.

Spec (possible) Negative_regulation (reducing) of VCAM-1

1) Confidence 0.36 Published 2001 Journal Atherosclerosis Section Title Doc Link 11689202 Disease Relevance 0.36 Pain Relevance 0.14

Moreover, we previously demonstrated that VCAM-1 blockade prevents blood-derived CD133+ accumulation in dystrophic muscle and that the VCAM-1-VLA-4 adhesion receptor pair has a critical role in the recruitment of these stem cells to dystrophic muscle vessels [16].

Negative_regulation (blockade) of VCAM-1 in muscle associated with adhesions

2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.69 Pain Relevance 0.08

Of interest, a decrease in VCAM-1 and ICAM was found shortly after infliximab treatment [8], [10].

Negative_regulation (decrease) of VCAM-1 associated with infliximab

3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773010 Disease Relevance 0.62 Pain Relevance 0.28

treatment reduces endothelial E-selectin and vascular cell adhesion molecule-1 in synovial samples, as well as the levels of E-selectin, intercellular adhesion molecule-1, IL-8 and vascular endothelial growth factor in the circulation [129].

Negative_regulation (reduces) of vascular cell adhesion molecule-1 associated with adhesions

4) Confidence 0.11 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.79 Pain Relevance 0.17

Reduction in expression of endothelial adhesion molecules (ICAM-1, VCAM-1, E-selectin and P-selectin) also contributes to the anti-inflammatory effect (Seljeflot et al 2002).

Negative_regulation (Reduction) of VCAM-1 associated with inflammation and adhesions

5) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.83 Pain Relevance 0.26

General Comments

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