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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.29
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
muscle 1
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 2 98.64 Very High Very High Very High
Inflammation 60 97.68 Very High Very High Very High
rheumatoid arthritis 107 96.36 Very High Very High Very High
Analgesic 1 94.80 High High
Arthritis 39 92.12 High High
cytokine 55 84.60 Quite High
Bioavailability 1 63.68 Quite High
antagonist 10 24.64 Low Low
chemokine 5 15.52 Low Low
psoriasis 1 14.40 Low Low
Disease Link Frequency Relevance Heat
Adhesions 17 100.00 Very High Very High Very High
INFLAMMATION 60 97.68 Very High Very High Very High
Rheumatoid Arthritis 112 96.36 Very High Very High Very High
Disease Progression 12 95.16 Very High Very High Very High
Apoptosis 8 93.60 High High
Acute Disease 3 91.68 High High
Muscular Dystrophy 70 90.16 High High
Increased Venous Pressure Under Development 11 86.56 High High
Arthritis 36 84.56 Quite High
Disease 46 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.
Spec (possible) Negative_regulation (reducing) of VCAM-1
1) Confidence 0.36 Published 2001 Journal Atherosclerosis Section Title Doc Link 11689202 Disease Relevance 0.36 Pain Relevance 0.14
Moreover, we previously demonstrated that VCAM-1 blockade prevents blood-derived CD133+ accumulation in dystrophic muscle and that the VCAM-1-VLA-4 adhesion receptor pair has a critical role in the recruitment of these stem cells to dystrophic muscle vessels [16].
Negative_regulation (blockade) of VCAM-1 in muscle associated with adhesions
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.69 Pain Relevance 0.08
Of interest, a decrease in VCAM-1 and ICAM was found shortly after infliximab treatment [8], [10].
Negative_regulation (decrease) of VCAM-1 associated with infliximab
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773010 Disease Relevance 0.62 Pain Relevance 0.28
treatment reduces endothelial E-selectin and vascular cell adhesion molecule-1 in synovial samples, as well as the levels of E-selectin, intercellular adhesion molecule-1, IL-8 and vascular endothelial growth factor in the circulation [129].
Negative_regulation (reduces) of vascular cell adhesion molecule-1 associated with adhesions
4) Confidence 0.11 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.79 Pain Relevance 0.17
Reduction in expression of endothelial adhesion molecules (ICAM-1, VCAM-1, E-selectin and P-selectin) also contributes to the anti-inflammatory effect (Seljeflot et al 2002).
Negative_regulation (Reduction) of VCAM-1 associated with inflammation and adhesions
5) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.83 Pain Relevance 0.26

General Comments

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