INT99176

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 7.50
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap)
Anatomy Link Frequency
germline 1
teeth 1
Fap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 4 93.20 High High
Inflammation 3 75.00 Quite High
abdominal pain 3 65.08 Quite High
imagery 16 54.24 Quite High
COX2 2 25.00 Low Low
Pain 4 12.96 Low Low
Central nervous system 12 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 232 100.00 Very High Very High Very High
Cancer 76 100.00 Very High Very High Very High
Desmoid Disease 52 100.00 Very High Very High Very High
Mouth Disease 4 99.92 Very High Very High Very High
Colon Cancer 30 99.60 Very High Very High Very High
Cyst 14 98.78 Very High Very High Very High
Basal Cell Nevus Syndrome 2 96.86 Very High Very High Very High
Syndrome 46 94.88 High High
Adenoma 24 93.96 High High
Hyperplasia 3 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desmoid tumors are a very important cause of mortality in patients with FAP.6 There is an approximate 1000-fold increase of developing desmoid tumors in FAP patients when compared to the general population.82 Desmoids can be found at any age and have been documented from infancy to 81 years of age.83 The most common age of presentation is between 20 and 40 years, with a median age of 30 years, as reviewed by Knudsen et al.84 The risk of such tumor formation is increased after prior surgery.
Positive_regulation (increase) of FAP associated with cancer, familial adenomatous polyposis and desmoid disease
1) Confidence 0.13 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 2.01 Pain Relevance 0.03
In comparable syndromes with a high risk of developing cysts in the jaws, such as the nevoid basal cell carcinoma syndrome, it is recommended that a routine panorex is made every 1–2 years for early disclosure of cysts.105 The incidence of the development of dental anomalies in FAP is clearly increased relative to that in normal individuals, and treatment at a later age has been described as complicated.106 It is therefore recommended that in the routine follow-up, a panorex is included at least every 2 years in a developing child until the teeth have erupted (?
Positive_regulation (increased) of FAP in teeth associated with basal cell nevus syndrome, syndrome, familial adenomatous polyposis, mouth disease and cyst
2) Confidence 0.13 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.38 Pain Relevance 0
The deletion, spanning about 10 centimorgans, encompassed the complete APC gene and can be considered as causative for FAP.
Positive_regulation (causative) of FAP associated with familial adenomatous polyposis
3) Confidence 0.13 Published 2001 Journal Am. J. Gastroenterol. Section Abstract Doc Link 11693343 Disease Relevance 1.38 Pain Relevance 0.07
Attenuated forms of FAP may be the result of mutations in the APC gene, or in the recently described MYH gene.
Positive_regulation (forms) of FAP associated with familial adenomatous polyposis
4) Confidence 0.05 Published 2005 Journal Cancer Causes Control Section Abstract Doc Link 15947872 Disease Relevance 1.69 Pain Relevance 0.09
FAP is caused by a germline mutation in APC gene.
Positive_regulation (caused) of FAP in germline
5) Confidence 0.04 Published 2002 Journal Bull. Acad. Natl. Med. Section Abstract Doc Link 12145848 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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