INT99281

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HCRT) cytoplasm (HCRT)
HCRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 5 99.74 Very High Very High Very High
Eae 36 97.00 Very High Very High Very High
amygdala 6 90.48 High High
alcohol 8 84.48 Quite High
antagonist 30 84.44 Quite High
Locus ceruleus 9 81.08 Quite High
noradrenaline 10 80.16 Quite High
fluoxetine 1 76.36 Quite High
antidepressant 9 48.24 Quite Low
sSRI 9 44.64 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 99 99.84 Very High Very High Very High
Stress 36 98.88 Very High Very High Very High
Anxiety Disorder 3 93.32 High High
Eating Disorder 1 86.20 High High
Hallucination 5 84.92 Quite High
Sleep Paralysis 5 83.84 Quite High
Ehlers-danlos Syndrome 7 58.20 Quite High
Recurrence 19 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Hypocretin (orexin) deficiency in narcolepsy-cataplexy].
Negative_regulation (deficiency) of orexin associated with neuropeptide and sleep disorders
1) Confidence 0.57 Published 2000 Journal Sb Lek Section Title Doc Link 11702580 Disease Relevance 0.71 Pain Relevance 0.18
Therefore, inhibiting OX-1/Hcrt-1 receptors attenuates the stress-like response leading to a reduction in yohimbine-induced reinstatement of reward seeking as seen in the present study.


Negative_regulation (inhibiting) of Hcrt associated with stress
2) Confidence 0.57 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0.38 Pain Relevance 0.24
However, it is clear that mutations in the hypocretin (orexin) receptor 2 gene cause genetic narcolepsy in several animal species (Chemelli et al 1999; Lin et al 1999) and there is no doubt that hypocretin/orexin deficiency is the most frequent cause of narcolepsy with cataplexy in humans (Peyron et al 2000; Thannickal et al 2000).
Negative_regulation (deficiency) of orexin associated with sleep disorders
3) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526380 Disease Relevance 1.17 Pain Relevance 0
The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.



Negative_regulation (inhibition) of Hcrt
4) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.16
We further show that inhibiting OX-1/Hcrt-1 receptors attenuates yohimbine-induced reinstatement of both ethanol and sucrose seeking.
Negative_regulation (inhibiting) of Hcrt
5) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.14

General Comments

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