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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.50
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (STS) nuclear envelope (STS) small molecule metabolic process (STS)
Golgi apparatus (STS) endoplasmic reticulum (STS) plasma membrane (STS)
Anatomy Link Frequency
endometrium 2
HeLa 1
uterine 1
STS (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 9 100.00 Very High Very High Very High
Pain 8 64.92 Quite High
ischemia 2 58.12 Quite High
iatrogenic 2 15.16 Low Low
Inflammation 27 8.52 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 170 100.00 Very High Very High Very High
Dysmenorrhea 9 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 10 99.64 Very High Very High Very High
Disease 65 98.72 Very High Very High Very High
Metastasis 16 98.52 Very High Very High Very High
Apoptosis 545 98.16 Very High Very High Very High
Toxicity 3 98.12 Very High Very High Very High
Recurrence 30 97.32 Very High Very High Very High
Acne 1 96.84 Very High Very High Very High
Infection 111 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistologic localization of estrone sulfatase in uterine endometrium and adenomyosis.
Localization (localization) of estrone sulfatase in uterine associated with dismenorea
1) Confidence 0.79 Published 2001 Journal Obstet Gynecol Section Title Doc Link 11704174 Disease Relevance 0.19 Pain Relevance 0.28
OBJECTIVE: To clarify histologic localization of estrone sulfatase in normal uterine endometrium and adenomyotic tissue and to confirm that estrone sulfatase is one of the enzymes that supplies estrogen to adenomyotic tissue.
Localization (localization) of estrone sulfatase in endometrium associated with dismenorea
2) Confidence 0.79 Published 2001 Journal Obstet Gynecol Section Abstract Doc Link 11704174 Disease Relevance 0.27 Pain Relevance 0.27
OBJECTIVE: To clarify histologic localization of estrone sulfatase in normal uterine endometrium and adenomyotic tissue and to confirm that estrone sulfatase is one of the enzymes that supplies estrogen to adenomyotic tissue.
Localization (localization) of estrone sulfatase in endometrium associated with dismenorea
3) Confidence 0.74 Published 2001 Journal Obstet Gynecol Section Abstract Doc Link 11704174 Disease Relevance 0.27 Pain Relevance 0.27
Only cases of localized or locally advanced STS, VS, or GIST will be selected (disease stage: TxNxM0).
Localization (localized) of STS associated with sarcoma, disease and gastrointestinal stromal tumor
4) Confidence 0.25 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2882909 Disease Relevance 1.66 Pain Relevance 0
In France (Rhone-Alpes region), a retrospective analysis of the medical records of 100 patients with localized STS (stage TxNxM0) revealed significant correlations between:

• local relapse and: quality of resection (p = .01); macroscopic extent of surgery (p = .002); subspecialty of the surgeon (p = .03); type of hospital (p = .02); review of patient file by multidisciplinary committee before surgery (p = .02); management in the cancer network (p = .02); conformity of radiotherapy with clinical practice guidelines (CPGs) (p = .007); • metastatic relapse and: histological grade (p = .008); multidisciplinary committee decision after surgery (p = 0.04)]; and management in the cancer network (p = .02) [18].

Localization (localized) of STS associated with sarcoma, cancer and recurrence
5) Confidence 0.24 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2882909 Disease Relevance 0.74 Pain Relevance 0
Of the four Autumnalis STs, ST27 and ST41 appear closely related in both Figure 2a and 2b, but unrelated to the other Autumnalis STs ST22 and ST34.
Localization (related) of STs
6) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2041815 Disease Relevance 0.23 Pain Relevance 0
The following is one of many possible antioxidant reactions as it scavenges ROS and may be responsible for producing glutathione:

STS is known to be a chelator of cations and has been used for over a century as an antidote for cyanide toxicity, topical treatments of acne and versicolor, and recently as a chemoprotectant against carboplatin and cisplatin toxicity.

Localization (used) of STS associated with toxicity and acne
7) Confidence 0.10 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.13 Pain Relevance 0.09
Since S. flexneri inhibits caspase-3 activation despite cytochrome c release in the presence of STS, caspase-10 could be a eukaryotic target for the bacteria to utilize to interfere with caspase-3 activation and inhibit apoptosis.
Localization (presence) of STS associated with apoptosis
8) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.32 Pain Relevance 0
Finally, there were more induced genes whose gene products are localized to the mitochondria in STS conditions (Additional file 2, Table S2).
Localization (localized) of STS
9) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.43 Pain Relevance 0
When used, STS was applied at a 4 ?
Localization (applied) of STS
10) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.23 Pain Relevance 0
These key points include the activation of pro-apoptotic proteins preceding damage to the mitochondria (0.5 to 1 hour STS incubation), cytochrome c release from the mitochondria (2 hour STS incubation), and activation of caspase-3 before significant damage to the HeLa nuclei (2.75 hour STS incubation).
Localization (release) of STS in HeLa associated with apoptosis
11) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.03 Pain Relevance 0

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