INT99290

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 6.96
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (STS) nuclear envelope (STS) small molecule metabolic process (STS)
Golgi apparatus (STS) endoplasmic reticulum (STS) plasma membrane (STS)
Anatomy Link Frequency
Joint 1
margins 1
sulcus 1
faces 1
upper 1
STS (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 4 96.84 Very High Very High Very High
amygdala 214 90.76 High High
depression 48 88.16 High High
Pain 16 87.68 High High
insula 20 84.72 Quite High
Anterior cingulate cortex 5 67.36 Quite High
transdermal 40 50.00 Quite Low
Dismenorea 3 50.00 Quite Low
withdrawal 3 47.40 Quite Low
Neuropeptide 1 44.88 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 273 100.00 Very High Very High Very High
Sprains And Strains 152 100.00 Very High Very High Very High
Cognitive Disorder 80 100.00 Very High Very High Very High
Sarcoma 70 100.00 Very High Very High Very High
Anxiety Disorder 14 98.64 Very High Very High Very High
Disease 39 95.26 Very High Very High Very High
Leiomyosarcoma 13 93.44 High High
Hypertension 2 88.20 High High
Depression 90 88.16 High High
Pain 12 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, all functional layers of the endometria were negative for staining for estrone sulfatase.
Positive_regulation (negative) of estrone sulfatase
1) Confidence 0.43 Published 2001 Journal Obstet Gynecol Section Body Doc Link 11704174 Disease Relevance 0.06 Pain Relevance 0
In other words, we assume that the perisylvian and STS activation we observed should be considered part of a crossmodal network which is responsive to simple sensory information to enable rapid associative learning.
Positive_regulation (activation) of STS
2) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0.05 Pain Relevance 0
Surgical resection with wide margins, with or without radiation therapy, remains the standard of care for localized disease with continued debate when deciding upon the use of adjuvant chemotherapeutic treatment options.12 Doxorubicin and ifosfamide have been used both as single agents and as combination therapy and remains the mainstay of treatment in most histologies of STS.
Positive_regulation (histologies) of STS in margins associated with sarcoma and disease
3) Confidence 0.38 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 1.21 Pain Relevance 0
In the present study, we found the STS activation patterns were more affected by the left-right than the upper-lower visual field presentation (Figure 4): for quadrant presentations the contralateral STS activated earlier than the ipsilateral STS, while for central presentation, the left STS was earlier than the right STS (82 ms vs. 93 ms).
Positive_regulation (activation) of STS in upper associated with cognitive disorder
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842434 Disease Relevance 0.97 Pain Relevance 0.17
Using stimuli from the Pictures of Facial Affect, we identified similar activated STS area as in a fMRI study that faces displaying an emotional expression were compared with those displaying a neutral expression [52].
Positive_regulation (activated) of STS in faces
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842434 Disease Relevance 0 Pain Relevance 0.21
The results reported here show clear evidence for early activation in “higher-order” areas, i.e. the STS, amygdale and MPFC activated well within 100 ms post-stimulus (Figure 4).
Positive_regulation (activation) of STS associated with cognitive disorder
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842434 Disease Relevance 0.10 Pain Relevance 0
However, an increase in SBP (without clinical symptoms) with combination STS 6 mg/24 hours and phenylpropanolamine has been reported (Azzaro et al 2007a).
Positive_regulation (increase) of STS
7) Confidence 0.37 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.25 Pain Relevance 0.09
In STS 12 mg/24 hours-treated subjects, the presence of food significantly increased, by approximately 3-fold, the mean tyramine dose required to elicit a clinically significant pressor response (Table 1).
Positive_regulation (increased) of STS
8) Confidence 0.35 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0 Pain Relevance 0
We also noticed robust activation of the bilateral supramarginal gyrus (SMG) which overarches the planum parietale (PPa), of the posterior auditory association cortex including the planum temporale (PT) and of the right posterior portion of the superior temporal sulcus (STS).
Positive_regulation (activation) of STS in sulcus
9) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0.07 Pain Relevance 0.04
Furthermore, specific STS activation has been reported for perceiving fear in dynamic body expressions [37], processing of complex social signals such as facial expressions and body images [38], observation of actions and understanding [39].
Positive_regulation (activation) of STS in body associated with anxiety disorder
10) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2453130 Disease Relevance 0.25 Pain Relevance 0.09
That is to say other factors might be hindering STS performance.
Positive_regulation (hindering) of STS
11) Confidence 0.19 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC1929086 Disease Relevance 0.26 Pain Relevance 0.13
As a result, in this step, more than 5,000,000 (9 × 85 × 85 × 85) variations of STS movements were acquired from the 85 variations of joint kinematic data and the link segment model.

3) Joint moment calculation

Positive_regulation (movements) of STS in Joint
12) Confidence 0.19 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC1929086 Disease Relevance 0 Pain Relevance 0
The population of O. tsutsugamushi is thus very diverse (Simpson's index 0.95), with a high number of STs per strain (49 STs in 89 strains, 0.55 STs per strain).
Positive_regulation (number) of STs associated with sprains and strains
13) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.89 Pain Relevance 0
The population of O. tsutsugamushi is thus very diverse (Simpson's index 0.95), with a high number of STs per strain (49 STs in 89 strains, 0.55 STs per strain).
Positive_regulation (number) of STs associated with sprains and strains
14) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.88 Pain Relevance 0
Knowing that S. flexneri inhibits STS-induced apoptosis at the level of caspase-3 activation [2] and given the changes in eukaryotic gene expression and resistance to TRAIL-induced apoptosis reported here, we propose that S. flexneri blocks apoptosis at multiple checkpoints in infected cells (Figure 4).
Positive_regulation (activation) of STS associated with apoptosis
15) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.72 Pain Relevance 0
Therefore, we hypothesize that either the bacteria use a T3SS effector protein to directly inhibit caspase-3 activation in the presence of STS, or that the bacteria indirectly block caspase-3 activation by upregulation of other pro-survival genes.
Positive_regulation (activation) of STS
16) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.36 Pain Relevance 0
The population of O. tsutsugamushi is thus very diverse (Simpson's index 0.95), with a high number of STs per strain (49 STs in 89 strains, 0.55 STs per strain).
Positive_regulation (number) of STs associated with sprains and strains
17) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.90 Pain Relevance 0

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