INT99453

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 13.28
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
MIA PaCa-2 2
SH-SY5Y 1
neuronal 1
cleavage 1
epithelial cells 1
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 880 99.88 Very High Very High Very High
cytokine 24 95.84 Very High Very High Very High
lidocaine 1 92.80 High High
Osteoarthritis 30 88.56 High High
Bile 2 86.16 High High
Inflammation 38 84.16 Quite High
alcohol 45 84.08 Quite High
metalloproteinase 7 81.36 Quite High
Chronic pancreatitis 4 76.52 Quite High
Paracetamol 6 74.96 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 232 99.84 Very High Very High Very High
Lung Cancer 17 99.84 Very High Very High Very High
Apoptosis 516 99.40 Very High Very High Very High
Cancer 151 98.56 Very High Very High Very High
Pancreatic Cancer 24 98.28 Very High Very High Very High
Necrosis 26 97.52 Very High Very High Very High
Lung Injury 3 97.20 Very High Very High Very High
Disease 25 94.32 High High
Injury 49 93.04 High High
Stress 79 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results are consistent with laboratory evidence that MnSOD expression plays a role in adaptive responses to ionizing radiation [40].
Gene_expression (expression) of MnSOD
1) Confidence 0.77 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.39 Pain Relevance 0.10
For the analysis of SOD2 mRNA expression, total RNA was extracted from 1 × 106 cells using a Trizol Reagent (Invitrogen) as described by the manufacturer.
Gene_expression (expression) of SOD2 mRNA
2) Confidence 0.76 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0 Pain Relevance 0.04
[52]; furthermore, thiol-reducing agents can affect SOD2 biosynthesis, as demonstrated by the enhanced SOD2 expression caused by thioredoxin, a potent disulfide oxidoreductase [31].
Gene_expression (expression) of SOD2
3) Confidence 0.76 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.35 Pain Relevance 0.10
The antiapoptotic role of SOD2 is even demonstrated by the resistance to the radiation-induced damage reported for cell lines overexpressing SOD2 [47].
Gene_expression (overexpressing) of SOD2
4) Confidence 0.76 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.64 Pain Relevance 0.22
Moreover, endogenously produced or exogenously added Trx increases the SOD2 expression in lung carcinoma [31] or neuronal cells [32].
Gene_expression (expression) of SOD2 in neuronal associated with lung cancer
5) Confidence 0.76 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.10 Pain Relevance 0.18
MnSOD was overexpressed in MIA PaCa-2 using an adenoviral vector, and the effect on cell growth was determined.
Gene_expression (overexpressed) of MnSOD in MIA PaCa-2
6) Confidence 0.75 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.71 Pain Relevance 0.06
Overexpression of MnSOD may be effective in growth suppression of pancreatic cancer.
Gene_expression (Overexpression) of MnSOD associated with pancreatic cancer
7) Confidence 0.75 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.56 Pain Relevance 0
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Gene_expression (expression) of MnSOD in MIA PaCa-2
8) Confidence 0.75 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.50 Pain Relevance 0
Codeinone stimulated the release of both cytochrome c and cytochrome oxidase, and cleavage of procaspase 3 without significant changes in both the activity and expression of MnSOD.
Gene_expression (expression) of MnSOD in cleavage
9) Confidence 0.73 Published 2003 Journal Anesthesiology Section Body Doc Link 12606908 Disease Relevance 0 Pain Relevance 0
The results showed a significant (P < 0.001) up-regulation of SOD2 gene expression in IL-1?
Gene_expression (expression) of SOD2 gene
10) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.23 Pain Relevance 0.07
Since MnSOD removes the superoxide anion, a potential source of DNA damage, one would predict that that the MnSOD Val allele would lead to an increased risk of cancer.
Gene_expression (allele) of MnSOD associated with cancer
11) Confidence 0.67 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.39 Pain Relevance 0.18
[52]; furthermore, thiol-reducing agents can affect SOD2 biosynthesis, as demonstrated by the enhanced SOD2 expression caused by thioredoxin, a potent disulfide oxidoreductase [31].
Gene_expression (biosynthesis) of SOD2
12) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.34 Pain Relevance 0.13
In fact, in mice a partial deficiency of the SOD2 gene (sod2(+/?))
Gene_expression (deficiency) of sod2
13) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 1.21 Pain Relevance 0.23
These observations confirm the regulation of SOD2 functions following a drug treatment; however, the differences observed among the various experimental systems indicate that the SOD2 response is a multifactorial process only poorly clarified.
Gene_expression (response) of SOD2
14) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.27 Pain Relevance 0.13
M SsTrx, the amount of SOD2 was even higher compared to untreated cells.
Gene_expression (amount) of SOD2
15) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.29 Pain Relevance 0.31
M diclofenac, the SOD2 protein level was significantly reduced.
Gene_expression (level) of SOD2 protein associated with diclofenac
16) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.20 Pain Relevance 0.24
In fact, in mice a partial deficiency of the SOD2 gene (sod2(+/?))
Gene_expression (deficiency) of SOD2 gene
17) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 1.21 Pain Relevance 0.23
This protection was accompanied by increased pulmonary MnSOD, VEGF expression and decreased apoptosis.
Gene_expression (expression) of MnSOD associated with apoptosis
18) Confidence 0.65 Published 2002 Journal Front. Biosci. Section Abstract Doc Link 12108429 Disease Relevance 0.68 Pain Relevance 0.17
MnSOD is synthesized in the cytoplasm as a precursor protein and is transported to the mitochondria, where it is processed and assembled into an active homotetramer.
Gene_expression (synthesized) of MnSOD
19) Confidence 0.60 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.45 Pain Relevance 0.17
Studies of MnSOD protein expression showed higher levels in non-neoplastic breast epithelial cells compared with levels in invasive breast cancer [6].
Gene_expression (expression) of MnSOD in epithelial cells associated with breast cancer
20) Confidence 0.60 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.48 Pain Relevance 0.17

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