INT99496

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.24
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD17B7) oxidoreductase activity (HSD17B7) endoplasmic reticulum (HSD17B7)
plasma membrane (HSD17B7)
Anatomy Link Frequency
brain 4
uterine 2
HSD17B7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 10 97.48 Very High Very High Very High
cerebral cortex 2 90.16 High High
Serotonin 4 85.84 High High
gABA 2 68.64 Quite High
depression 4 59.12 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 97.48 Very High Very High Very High
Fatigue 4 64.00 Quite High
Reprotox - General 1 4 61.92 Quite High
Post-partum Depression 4 60.08 Quite High
Epilepsy 4 57.28 Quite High
Depressive Disorder 4 56.48 Quite High
Dementia 2 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain.
Gene_expression (presence) of 17beta-hydroxysteroid dehydrogenase in brain
1) Confidence 0.78 Published 2001 Journal Eur. J. Endocrinol. Section Abstract Doc Link 11720889 Disease Relevance 0.35 Pain Relevance 0.13
Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain.
Gene_expression (presence) of 17beta-hydroxysteroid dehydrogenase in brain
2) Confidence 0.68 Published 2001 Journal Eur. J. Endocrinol. Section Abstract Doc Link 11720889 Disease Relevance 0.35 Pain Relevance 0.13
The presence of the steroidogenic enzymes cytochrome P450(SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase in the human brain has now been firmly established by molecular biological and biochemical studies.
Gene_expression (presence) of 17beta-hydroxysteroid dehydrogenase in brain
3) Confidence 0.66 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993041 Disease Relevance 0 Pain Relevance 0.11
The presence of the steroidogenic enzymes cytochrome P450(SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase in the human brain has now been firmly established by molecular biological and biochemical studies.
Gene_expression (presence) of 17beta-hydroxysteroid dehydrogenase in brain
4) Confidence 0.66 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993041 Disease Relevance 0 Pain Relevance 0.11
OBJECTIVE: The aim of this study was to demonstrate the temporal and spatial expression of estrogen receptor (ER), 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in uterine endometria and the endometrial-myometrial interface (EMI) of adenomyosis and the effects of estrogen activity-related molecules on the occurrence of adenomyosis.
Gene_expression (expression) of 17beta-hydroxysteroid dehydrogenase in uterine associated with dismenorea
5) Confidence 0.07 Published 2004 Journal Zhonghua Fu Chan Ke Za Zhi Section Abstract Doc Link 15130351 Disease Relevance 0.27 Pain Relevance 0.27
OBJECTIVE: The aim of this study was to demonstrate the temporal and spatial expression of estrogen receptor (ER), 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in uterine endometria and the endometrial-myometrial interface (EMI) of adenomyosis and the effects of estrogen activity-related molecules on the occurrence of adenomyosis.
Gene_expression (expression) of 17beta-HSD in uterine associated with dismenorea
6) Confidence 0.06 Published 2004 Journal Zhonghua Fu Chan Ke Za Zhi Section Abstract Doc Link 15130351 Disease Relevance 0.27 Pain Relevance 0.27

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