INT9968

Context Info Confidence 0.00 First Reported 1992 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 15 Total Number 19 Disease Relevance 10.45 Pain Relevance 8.64

cytosol (Rab38) vesicle-mediated transport (Rab38) Golgi apparatus (Rab38) endoplasmic reticulum (Rab38) GTPase activity (Rab38) cytoplasm (Rab38)

Anatomy Link Frequency liver 3 neurons 3 neuronal 2 sympathetic 2 visceral 1 Rab38 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 12 100.00 sodium channel 7 100.00 electroacupuncture 33 99.98 Clonidine 22 99.82 Opioid 6 99.80 Central nervous system 8 98.72 bradykinin 8 98.60 dorsal root ganglion 23 98.56 Nerve growth factor 10 97.56 orphanin 5 96.64

Disease Link Frequency Relevance Heat Injury 301 99.76 Diabetes Mellitus 16 98.92 Ganglion Cysts 25 98.56 Body Weight 170 98.28 Convulsion 8 95.92 Hypotension 10 94.96 Hyperalgesia 5 94.04 Pain 3 93.32 Diabetic Neuropathy 2 92.60 Hypoalagesia 1 90.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Gabazine also reversed EA inhibition of cardiovascular premotor sympathetic rVLM neurons.

Negative_regulation (inhibition) of rVLM in neurons associated with electroacupuncture

1) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17890425 Disease Relevance 0.45 Pain Relevance 1.29

Treatment with the glutamate antagonists MK-801 (1 mg kg-1) and NBQX (30 mg kg-1 x 2) did not significantly change this, although MK-801 tended to reduce the size of the metabolic penumbra calculated as the difference between ischemic cortex with reduced PS and ischemic cortex with reduced rCMRglc.

Negative_regulation (reduced) of rCMRglc in cortex associated with glutamate and antagonist

2) Confidence 0.30 Published 1999 Journal Neurol. Res. Section Abstract Doc Link 10555193 Disease Relevance 0.07 Pain Relevance 0.13

In control rats, clonidine caused a significant reduction in MAP that continued for at least 6 h and was associated with reductions in SDMAP and SDRR but not rMSSD, suggesting inhibition of central sympathetic tone.

Negative_regulation (reductions) of rMSSD in sympathetic associated with clonidine

3) Confidence 0.23 Published 2004 Journal Vascul. Pharmacol. Section Abstract Doc Link 15196476 Disease Relevance 0.58 Pain Relevance 0.50

In control rats, clonidine caused a significant reduction in MAP that continued for at least 5 h and was associated with significant reductions in SDMAP, SDRR, and rMSSD, responses that are consistent with the inhibition of central sympathetic tone.

Negative_regulation (reductions) of rMSSD in sympathetic associated with clonidine

4) Confidence 0.14 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660306 Disease Relevance 0.16 Pain Relevance 0.60

The clonidine-induced reductions in SDMAP, SDRR, and rMSSD were also significantly attenuated by ethanol.

Negative_regulation (reductions) of rMSSD associated with clonidine

5) Confidence 0.14 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660306 Disease Relevance 0.09 Pain Relevance 0.57

These results suggest that an acute inhibition of TTX-R I(Na) by LY333531 attenuates the exaggerated excitability of DRG neurons in the diabetic state, which appears to be related at least partly to anti-hyperalgesic actions of the drug in diabetic neuropathy.

Negative_regulation (inhibition) of TTX-R in DRG associated with dorsal root ganglion, hyperalgesia, diabetes mellitus and diabetic neuropathy

6) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17339081 Disease Relevance 1.59 Pain Relevance 0.56

Bath application of LY333531 acutely inhibited TTX-R I(Na) in both control and diabetic DRG neurons, and the degree of inhibition by the drug at concentrations of 1, 10 and 100 nM was significantly greater in diabetic DRG neurons than in control DRG neurons.

Negative_regulation (inhibited) of TTX-R in neurons associated with dorsal root ganglion and diabetes mellitus

7) Confidence 0.08 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17339081 Disease Relevance 1.35 Pain Relevance 0.59

M, thiopental abolished SPW-R activity in two out of ten slices.

Negative_regulation (abolished) of SPW-R

8) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.07 Pain Relevance 0.12

Neuronal activity in the rVLM induced by splanchnic nerve stimulation was reduced for 50 (or more) min after termination of EA in 7 of 12 rVLM neurons.

Negative_regulation (reduced) of rVLM in Neuronal associated with electroacupuncture

9) Confidence 0.02 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12878081 Disease Relevance 0.07 Pain Relevance 0.51

These outcomes indicate that HD-MTX and the reduced rCMRGlc that follows this treatment do not contribute to the hypnotic action of phenobarbital.

Negative_regulation (reduced) of rCMRGlc

10) Confidence 0.01 Published 1992 Journal Pharm. Res. Section Abstract Doc Link 1448429 Disease Relevance 0.39 Pain Relevance 0.35

The mechanism by which hepatic SOD, catalase, Se-GSHpx, GSSG-R, and G-6-PDH activities are reduced with liver injury development in rats treated with ANIT has not been elucidated.

Negative_regulation (reduced) of GSSG-R in liver associated with injury

11) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.71 Pain Relevance 0

Oral administration of TJ-10 (1.3 or 2.6 g/kg BW) to ANIT-treated rats at an early stage of liver injury significantly attenuated the decreases in hepatic SOD, catalase, Se-GSHpx, GSSG-R, and G-6-PDH activities found at a progressed stage of liver injury.

Negative_regulation (decreases) of GSSG-R in liver associated with body weight and injury

12) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 1.03 Pain Relevance 0.14

Our previous reports have shown that, in rats treated once with ANIT, hepatic SOD and GSSG-R activities decrease with injury formation and progression, while catalase, and Se-GSHpx activities decrease with liver injury progression [7–9].

Negative_regulation (decrease) of GSSG-R in liver associated with injury

13) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 1.09 Pain Relevance 0.18

We determined whether the altered neuronal function after HD-MTX [such as the reduced regional cerebral metabolic glucose rate (rCMRGlc) and slow electroencephalographic pattern] affects the sensitivity of the CNS to centrally acting drugs: the depressant phenobarbital, which reduces rCMRGlc, and the analeptic agent pentylenetetrazol (PTZ), which elevates rCMRGlc.

Negative_regulation (reduces) of rCMRGlc in neuronal associated with central nervous system

14) Confidence 0.01 Published 1992 Journal Pharm. Res. Section Abstract Doc Link 1448429 Disease Relevance 0.32 Pain Relevance 0.26

Mean TTX-R sodium current density was decreased from 504 +/- 77 pA/pF to 307 +/- 61 pA/pF in control versus NGF-deprived neurons, respectively.

Negative_regulation (decreased) of TTX-R in neurons associated with nerve growth factor

15) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10036280 Disease Relevance 0.64 Pain Relevance 0.92

Therefore, it seems likely that the enhanced decreases in hepatic SOD and GSSG-R activities and the decrease in hepatic catalase, Se-GSHpx, and G-6-PDH activities found at a progressed stage of liver injury in ANIT-treated rats are due to ROS derived from neutrophils accumulating in the tissue.

Negative_regulation (decrease) of GSSG-R in neutrophils associated with injury

16) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.75 Pain Relevance 0.03

Sensory neuron specific TTX-R sodium channel NaV1. 8 transcript was down-regulated after antisense oligonucleotide injection at the dosage of 45 microg as compared with that in CCI group (P < 0.01), and it was even greater at the dosage of 90 microg.

Negative_regulation (down-regulated) of TTX-R in Sensory neuron associated with sodium channel

17) Confidence 0.01 Published 2005 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 16696329 Disease Relevance 0.55 Pain Relevance 0.77

In the ANIT-treated group, further decreases in hepatic SOD and GSSG-R activities occurred with decreases in hepatic catalase, Se-GSHpx, and G-6-PDH activities at 48 h after the treatment (Figs. 6 and 7).

Negative_regulation (decreases) of GSSG-R

18) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.55 Pain Relevance 0

These data suggest that EA attenuates BK-induced visceral sympathoexcitatory reflexes through opioid-mediated inhibition of Glu's action in the rVLM.

Negative_regulation (inhibition) of rVLM in visceral associated with glutamate, opioid, bradykinin and electroacupuncture

19) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17158649 Disease Relevance 0 Pain Relevance 1.11

General Comments

This test has worked.