INT99708

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 7
Total Number 38
Disease Relevance 7.42
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf7) extracellular region (Fgf7) Golgi apparatus (Fgf7)
Anatomy Link Frequency
cartilage 9
chondrocytes 5
keratinocyte 4
fibroblasts 2
nasal septum 2
Fgf7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 98.52 Very High Very High Very High
Snapping jaw 32 96.20 Very High Very High Very High
IPN 4 86.88 High High
Immobilon 32 16.80 Low Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 4 100.00 Very High Very High Very High
Wound Healing 512 99.88 Very High Very High Very High
Osteoporosis 32 99.08 Very High Very High Very High
Pancreatitis 4 98.52 Very High Very High Very High
Injury 192 97.72 Very High Very High Very High
Rheumatoid Arthritis 45 96.56 Very High Very High Very High
Temporomandibular Joint Syndrome 32 96.20 Very High Very High Very High
Focal Cartilage Defect 32 94.24 High High
Osteoarthritis 32 91.88 High High
Immunization 32 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyze KGF and KGFR expression, the cells were further incubated in collagen-coated chamber slides (Lab-Tek, Nalge Nunc International, Naperville, IL, USA) for 2 more days.
Spec (analyze) Gene_expression (expression) of KGF
1) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.13 Pain Relevance 0
We have already reported the immunohistochemical expression of KGF on alveolar epithelium cells in rat lung resection model [18].
Gene_expression (expression) of KGF in lung
2) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.17 Pain Relevance 0
For this purpose, we examined immunohistochemically the expression of KGF and KGFR in relation to proliferative activity in a rat model of regenerating tracheal cartilage.
Spec (examined) Gene_expression (expression) of KGF in cartilage
3) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.16 Pain Relevance 0
Expression of KGF and KGFR in primary cultured chondrocytes
Gene_expression (Expression) of KGF in chondrocytes
4) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.08 Pain Relevance 0
In that study we noted the strong expression of KGF in tracheal cartilages, suggesting its possible roles in the regulation of mass homeostasis of the tracheal cartilage, including wound healing.
Gene_expression (expression) of KGF in cartilage associated with wound healing
5) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.18 Pain Relevance 0
Cell proliferation and expression of KGF and KGFR in tracheal cartilage after surgery
Gene_expression (expression) of KGF in cartilage
6) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.18 Pain Relevance 0
Finch et al. [8] reported that KGF and KGFR are expressed on the cartilage of limbs, ribs, larynx, and trachea from embryonic stage, it is possible that the use of KGF with these growth factors may have enhancing, competitive, or other specific effects on the hyaline cartilage.
Gene_expression (expressed) of KGF in trachea associated with osteoarthritis
7) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.26 Pain Relevance 0.10
KGF is currently known to be expressed in a variety of tissues, including the lungs [9, 23, 37], prostate, [13] mammary glands [12, 29], digestive tract [22], skin [26], and uterus [14], and is implicated in organ development, mass homeostasis, and carcinogenesis.
Gene_expression (expressed) of KGF in skin
8) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.16 Pain Relevance 0
Since KGF promotes cell differentiation under certain conditions [28], it is conceivable that the expression of KGF in normal cartilage serves to maintain cartilage function in an autocrine/paracrine manner.
Gene_expression (expression) of KGF in cartilage
9) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.15 Pain Relevance 0
Recently, Lazarus et al. [17] reported the expression of KGF and its receptor by real-time RT-PCR in the rat tibial perichondrium and growth plate, and suggested that perichondrial KGF regulates growth plate chondrogenesis.
Gene_expression (expression) of KGF in growth plate
10) Confidence 0.76 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.21 Pain Relevance 0
Changes in the expression of KGF and KGFR are less pronounced.


Gene_expression (expression) of KGF
11) Confidence 0.66 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737224 Disease Relevance 0.06 Pain Relevance 0
These peptide growth factors and their receptors c-met and keratinocyte growth factor receptor (KGFR) are overexpressed in pancreatic cancer.
Gene_expression (overexpressed) of keratinocyte growth factor in keratinocyte associated with pancreatic cancer
12) Confidence 0.66 Published 2001 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 11737224 Disease Relevance 0.17 Pain Relevance 0.07
Expression of hepatocyte growth factor, keratinocyte growth factor and their receptors in experimental chronic pancreatitis.
Gene_expression (Expression) of keratinocyte growth factor in keratinocyte associated with chronic pancreatitis
13) Confidence 0.66 Published 2001 Journal Eur. J. Clin. Invest. Section Title Doc Link 11737224 Disease Relevance 0.10 Pain Relevance 0.10
In primary cultures of rat nasal septum chondrocytes, a strong staining was detected for KGF in the cytoplasm (Fig. 7A).
Gene_expression (detected) of KGF in chondrocytes
14) Confidence 0.66 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical detection of KGF and KGFR in normal rat tracheal and nasal septum cartilage
Gene_expression (detection) of KGF in cartilage
15) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0 Pain Relevance 0
KGF was also detected in the blood vessels, stroma and epithelium of the trachea, and the positive cells were identified as endothelial cells, infiltrating lymphocytes, fibroblasts, and glandular epithelial cells in the tracheal wall.
Gene_expression (detected) of KGF in endothelial cells
16) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0 Pain Relevance 0
Expression of Keratinocyte Growth Factor and Its Receptor in Rat Tracheal Cartilage: Possible Involvement in Wound Healing of the Damaged Cartilage

Keratinocyte growth factor (KGF) is involved in the development and regeneration of a variety of tissues.

Gene_expression (Expression) of Keratinocyte Growth Factor in Cartilage associated with wound healing
17) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2896696 Disease Relevance 0.41 Pain Relevance 0
For immunohistochemical analysis, anti-KGF antibody (IgG, 10 µg/ml for tissue sections, 5 µg/ml for cultured cells) and anti-KGFR antisera (1:400 for tissue sections, 1:200 for cultured cells) were used to identify KGF and KGFR expression, respectively.
Gene_expression (expression) of KGF
18) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.09 Pain Relevance 0
KGF expression in normal rat tracheal cartilage and primary cultured rat chondrocytes by western blot analysis
Gene_expression (expression) of KGF in chondrocytes
19) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.07 Pain Relevance 0
These results indicated the expression of KGF in the rat tracheal cartilage, nasal septum cartilage, and primary cultured rat nasal septum chondrocytes.


Gene_expression (expression) of KGF in nasal septum
20) Confidence 0.59 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.05 Pain Relevance 0

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