INT99739

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Context Info
Confidence 0.87
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 9 98.96 Very High Very High Very High
anesthesia 6 95.36 Very High Very High Very High
Spinal cord 1 84.88 Quite High
Inflammation 14 51.20 Quite High
ischemia 5 49.12 Quite Low
cva 1 48.08 Quite Low
cytokine 4 47.36 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 27 99.48 Very High Very High Very High
Hypoxia 1 99.44 Very High Very High Very High
Disease 6 96.32 Very High Very High Very High
Apoptosis 107 95.28 Very High Very High Very High
Malignant Neoplastic Disease 4 93.24 High High
Cancer 4 92.56 High High
Necrosis 1 92.08 High High
Atherosclerosis 70 90.80 High High
Thrombophilia 2 83.76 Quite High
Colon Cancer 1 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAI-1 plays an important role in the process of peripheral tissue remodeling and fibrinolysis through inhibition of plasmin-dependent ECM degradation [67].
Protein_catabolism (degradation) of PAI
1) Confidence 0.87 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.54 Pain Relevance 0.09
Thrombin/antithrombin III complex (TAT), soluble fibrin (SF), total fibrinogen and fibrin degradation products (TDP), plasminogen activator inhibitor type-1 (PAI-1), urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) were measured preoperatively, starting anesthesia, during surgery and postoperatively.
Protein_catabolism (degradation) of plasminogen activator inhibitor type-1 associated with anesthesia
2) Confidence 0.21 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738072 Disease Relevance 0.67 Pain Relevance 0.17
Our data in cultured VSMCs show that statins upregulate the profibrotic mediator CTGF, the inhibitor of ECM degradation PAI-1, and collagen production, all of them regulated by Smads [7], [29], [30].
Protein_catabolism (degradation) of PAI-1
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.50 Pain Relevance 0.03
, via Smad pathway, regulates ECM-related proteins, including the profibrotic mediator CTGF [4], [26], the inhibitor of ECM degradation, PAI-1, [27], and the main ECM component Type I Collagen (Col-1) [4].
Protein_catabolism (degradation) of PAI-1
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0

General Comments

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