INT99763

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.08
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1) cytoplasm (Thbs1)
Anatomy Link Frequency
myometrium 1
spine 1
synapse 1
Thbs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 78.96 Quite High
Gabapentin 3 28.80 Quite Low
Dismenorea 1 25.00 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 363 99.84 Very High Very High Very High
Generaliased Trisomy 3 72.68 Quite High
Cognitive Disorder 12 58.32 Quite High
Stress 12 38.52 Quite Low
Parkinson's Disease 12 37.68 Quite Low
Apoptosis 3 34.24 Quite Low
Cancer 3 21.96 Low Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effect of spine alterations and TSP-1 deficits on synapse formation and activity in DS cocultures.
Spec (investigated) Regulation (effect) of TSP-1 in synapse associated with syndrome
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.41 Pain Relevance 0
The ability of TSP-1 to modulate spine formation (Figure 4), to rescue spine defects associated with DS and TSP-1 KO cocultures (Figure 6 and 7), and its capacity to stimulate synaptogenesis [20], prompted us to examine the effect of TSP-1 treatment on synapse formation in neurons growing on top of DS astrocytes.
Spec (examine) Regulation (effect) of TSP-1 in spine associated with syndrome
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.72 Pain Relevance 0
signaling in the post-transcriptional regulation of TSP-1 in DS.
Regulation (regulation) of TSP-1 associated with syndrome
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.95 Pain Relevance 0.04
Our objective was to examine the topology-, gestation- and labor-related changes of estrogen receptor (ER)alpha, progesterone receptor (PR), oxytocin receptor (OTR) and thrombospondin-1 (TSP1) mRNA in pregnant baboon myometrium.
Regulation (changes) of thrombospondin-1 in myometrium
4) Confidence 0.01 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0

General Comments

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