INT99777

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.71
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
orbit 2
fibroblasts 2
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 95.68 Very High Very High Very High
chemokine 13 93.00 High High
Inflammation 78 88.08 High High
cytokine 29 83.52 Quite High
Arthritis 2 70.16 Quite High
psoriasis 2 68.56 Quite High
agonist 18 21.28 Low Low
Inflammatory response 5 14.72 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 53 99.92 Very High Very High Very High
Eye Disease 126 96.24 Very High Very High Very High
Ocular & Orbital Inflammation 2 88.08 High High
Thyroid Disease 8 86.64 High High
INFLAMMATION 81 84.56 Quite High
Enteropathy 2 78.16 Quite High
Injury 4 75.04 Quite High
Multiple Sclerosis 2 74.48 Quite High
Immunization 22 72.88 Quite High
Arthritis 2 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutralization of CXCR2 during IP-10 therapy resulted in an abrogation of the hepatoprotective effect of IP-10.
Positive_regulation (resulted) of Localization (Neutralization) of IP-10
1) Confidence 0.50 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.22 Pain Relevance 0.45
Intriguingly, vaults containing another protein, GL, but not empty vaults, also significantly induced the maturation of BMDC by causing secretion of IL-12p70, IL-10 and CXCL10 but not IL-4 (data not shown) suggesting that vaults containing proteins favor induction of Th1 immune responses.
Positive_regulation (causing) of Localization (secretion) of CXCL10
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.30 Pain Relevance 0.39
CXCL10 release enhances the migration of T lymphocytes into the orbit, where they secrete IFN?
Positive_regulation (enhances) of Localization (release) of CXCL10 in orbit
3) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 1.52 Pain Relevance 0.16
synergistically induced CXCL10 release by orbital fibroblasts, thereby perpetuating a positive feedback loop [35, 50, 103].
Positive_regulation (induced) of Localization (release) of CXCL10 in fibroblasts
4) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 1.67 Pain Relevance 0.24

General Comments

This test has worked.

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