INT99843

Context Info Confidence 0.25 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.42 Pain Relevance 0.31

extracellular space (Edn3, Ren) extracellular region (Edn3, Ren) peptidase activity (Ren) intracellular (Ren) cellular_component (Edn3) response to stress (Ren)

Anatomy Link Frequency kidney 2 Edn3 (Rattus norvegicus) Ren (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 3 99.36 Restless leg syndrome 1 85.88 Serotonin 3 75.04

Disease Link Frequency Relevance Heat Glaucoma 1 87.40 Dementia 1 86.84 Increased Venous Pressure Under Development 3 85.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inhibition of forskolin-induced renin secretion by endothelin-3 in primary cultures of mouse juxtaglomerular cells and by endothelin-1 in the isolated perfused rat kidney could not be blocked by naftidrofuryl.

endothelin-3 Negative_regulation (inhibition) of Localization (secretion) of renin in kidney

1) Confidence 0.25 Published 2002 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11743222 Disease Relevance 0.42 Pain Relevance 0.31

General Comments

This test has worked.