INT9987

Context Info Confidence 0.78 First Reported 1980 Last Reported 2010 Negated 4 Speculated 6 Reported most in Abstract Documents 296 Total Number 302 Disease Relevance 95.46 Pain Relevance 226.34

mitochondrion (Abat)

Anatomy Link Frequency neurons 22 spinal cord 14 hippocampus 12 brain 11 striatum 7 Abat (Rattus norvegicus)

Pain Link Frequency Relevance Heat gABA 6291 100.00 Glutamate 1883 100.00 Dopamine 1881 100.00 agonist 1129 100.00 Neurotransmitter 979 100.00 Pain 875 100.00 Serotonin 346 100.00 substance P 314 100.00 GABA receptor 257 100.00 Enkephalin 220 100.00

Disease Link Frequency Relevance Heat Ganglion Cysts 893 100.00 Pain 944 99.90 Generalized Anxiety Disorder 568 99.90 Parkinson's Disease 363 99.80 Stress 629 99.78 Diabetes Mellitus 91 99.74 INFLAMMATION 355 99.70 Nociception 280 99.70 Urological Neuroanatomy 158 99.68 Injury 622 99.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data suggest that GABA receptors, which are coupled to Cl- channels, are also expressed by astrocytes in an intact tissue.

Gene_expression (expressed) of GABA in astrocytes associated with gaba receptor

1) Confidence 0.78 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2477511 Disease Relevance 0 Pain Relevance 0.56

This projection coexpresses GABA and enkephalin, posing a role for mu-opioid receptors in the ventral pallidum in mediating the reinstatement of cocaine seeking.

Gene_expression (coexpresses) of GABA in pallidum associated with gaba, mu opioid receptor, enkephalin and cocaine

2) Confidence 0.76 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15872098 Disease Relevance 0 Pain Relevance 0.77

The data also suggest that GABA(B) subunit gene expression may serve as a preclinical marker of antidepressant efficacy and of drug- or stress-induced modifications in central nervous system activity.

Gene_expression (expression) of GABA in central nervous system associated with stress, antidepressant, gaba and central nervous system

3) Confidence 0.76 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.39 Pain Relevance 1.29

GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants.

Gene_expression (expression) of GABA in spinal cord associated with stress, antidepressant, gaba, antinociceptive and spinal cord

4) Confidence 0.76 Published 2006 Journal Brain Res. Section Title Doc Link 16368079 Disease Relevance 0.39 Pain Relevance 1.52

Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain.

Gene_expression (expression) of GABA in spinal cord associated with gaba, thermal hyperalgesia, neuropathic pain, endep and spinal cord

5) Confidence 0.73 Published 2005 Journal Biochem. Pharmacol. Section Title Doc Link 16293232 Disease Relevance 0.74 Pain Relevance 1.47

The results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35S]GTPgammaS binding and GABA(B) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in GABAergic transmission.

Gene_expression (expression) of GABA in spinal cord associated with pain, gaba, gabaergic, neuropathic pain, sciatic nerve, withdrawal and spinal cord

6) Confidence 0.73 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.73 Pain Relevance 1.38

In this study, we have investigated the effects of gabapentin on recombinant GABA(B(1a)) and GABA(B(1b)) receptors coexpressed with GABA(B(2)) in five different functional recombinant assays, its ability to inhibit [(3)H]GABA binding in a GABA(B) receptor-selective binding assay using rat synaptic membranes, and its ability to inhibit transient lower esophageal sphincter relaxations in Labrador retriever dogs.

Gene_expression (coexpressed) of GABA in esophageal sphincter associated with gaba and gabapentin

7) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021399 Disease Relevance 0 Pain Relevance 0.92

Hence, the present study was undertaken to assess the peripheral analgesic, antiallodynic and antihyperalgesic activities of the synthesized structural analogues of GABA.

Gene_expression (synthesized) of GABA associated with antihyperalgesic, gaba, analgesic and antiallodynic

8) Confidence 0.68 Published 2008 Journal Pharmacology Section Abstract Doc Link 17785996 Disease Relevance 0.17 Pain Relevance 0.82

Differential expression of GABA(B(1b)) receptor mRNA in the thalamus of normal and monoarthritic animals.

Gene_expression (expression) of GABA in thalamus associated with gaba and thalamus

9) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15451403 Disease Relevance 0.09 Pain Relevance 0.47

In this study, we evaluated whether the expression of GABA(B(1b)) receptor mRNA is regulated supraspinally, namely in the thalamus, as part of the response to chronically enhanced noxious input arising from experimental monoarthritis (MA).

Gene_expression (expression) of GABA in thalamus associated with gaba and thalamus

10) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.10 Pain Relevance 0.43

No expression of GABA(B(1b)) mRNA was found in the Rt of control or MA animals.

Gene_expression (expression) of GABA associated with gaba

11) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.07 Pain Relevance 0.52

The amount of GABA(B(1b)) mRNA was expressed as times fold of background values.

Gene_expression (expressed) of GABA associated with gaba

12) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.08 Pain Relevance 0.44

The distribution of GABA(B(1b)) mRNA was determined bilaterally in the ventrobasal complex (VB), posterior (Po), centromedial/centrolateral (CM/CL) and reticular (Rt) thalamic nuclei.

Spec (determined) Gene_expression (distribution) of GABA in posterior associated with gaba

13) Confidence 0.67 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.08 Pain Relevance 0.45

We conclude that NO may be directly acting on GABA nerve terminals and tonically inhibiting GABA release or synthesis under basal conditions.

Gene_expression (synthesis) of GABA in nerve associated with gaba

14) Confidence 0.67 Published 1995 Journal Neuroreport Section Abstract Doc Link 7488740 Disease Relevance 0 Pain Relevance 0.45

Experiments were undertaken to examine whether once daily i.p. administration of either of two antidepressants used for the treatment of neuropathic pain, amitriptyline (10 mg/kg) and fluoxetine (5 mg/kg), to rats for 7 days modifies GABA(B) receptor function and subunit expression in the lumbar spinal cord.

Gene_expression (expression) of GABA in spinal cord associated with gaba, antidepressant, neuropathic pain, endep, spinal cord and fluoxetine

15) Confidence 0.66 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.32 Pain Relevance 1.13

Differential regulation of GABA B receptor subunit expression and function.

Gene_expression (expression) of GABA associated with gaba

16) Confidence 0.64 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12649368 Disease Relevance 0.14 Pain Relevance 0.85

The results indicate a lack of concordance between expression of GABA(B1) and GABA(B2) subunits and GABA(B) receptor function, suggesting these subunit proteins may serve multiple functions in the cells.

Gene_expression (expression) of GABA associated with gaba

17) Confidence 0.64 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.16 Pain Relevance 1.01

In the present study, experiments were undertaken to examine the relationship between GABA(B) receptor function and subunit expression in the rat lumbar spinal cord following pharmacological and physiological manipulation of this receptor system.

Gene_expression (expression) of GABA in spinal cord associated with gaba and spinal cord

18) Confidence 0.64 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.09 Pain Relevance 0.59

Although formalin-induced hind paw inflammation increases the production of GABA(B1) and GABA(B2) protein in the spinal cord within 24 h, there is no change in receptor function, as measured by the baclofen-stimulated guanosine 5'-O-(3-[(35)S]thiotriphosphate) ([(35)S]GTPgammaS) binding assay.

Gene_expression (production) of GABA in spinal cord associated with gaba, inflammation and spinal cord

19) Confidence 0.64 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.16 Pain Relevance 0.75

The GABA-transaminase-inhibitors decreased the striatal levels of the opioid peptides met-enkephalin and dynorphin(1-8) and concomitantly decreased the concentrations of the mRNAs coding for proenkephalin and prodynorphin.

Gene_expression (decreased) of GABA-transaminase associated with gaba, dynorphin, enkephalin and opioid

20) Confidence 0.63 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1647482 Disease Relevance 0 Pain Relevance 0.81

General Comments

This test has worked.