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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT282821 TACR1 Regulation of P2RX7 1 2 0.01 2.06 0.54
2 INT342633 ACE Regulation of Gene_expression of AGT 1 1 0.01 0.14 0.46
3 INT282820 Binding of TACR1 and NCOR2 1 1 0.00 0.88 0.39
4 INT282852 Binding of Slc37a4 and Slc5a8 1 3 0.01 0.77 0.21
5 INT282851 Binding of Slc37a4 and Sema6a 1 1 0.00 0.55 0.21
6 INT250632 Binding of MCPH1 and Fbxo23 1 1 0.01 0 0.11
7 INT250635 Ppara Positive_regulation of SLC16A13 1 1 0.22 0 0.05
8 INT250633 MCTS1 Positive_regulation of Gene_expression of Fbxo23 1 1 0.02 0 0.03
9 INT284392 Binding of ABCA1 and Vegfa 1 2 0.00 0.71 0
10 INT250630 CLTC Negative_regulation of Gene_expression of Fbxo23 1 1 0.00 0 0
11 INT250591 Binding of BSG and MCTS1 Regulation of MCTS1 1 1 0.06 0.5 0
12 INT284372 Binding of ABCA1 and AMT 1 1 0.00 0 0
13 INT250589 Binding of SLC16A7 and MCTS1 1 1 0.14 0 0
14 INT284391 Binding of AMT and Alms1 1 1 0.00 0 0
15 INT250588 Binding of BSG and MCTS1 1 4 0.11 1.83 0
16 INT284393 Positive_regulation of Binding of ABCA1 and Vegfa 1 1 0.00 0.36 0
17 INT250590 Binding of SLC16A4 and MCTS1 1 1 0.12 0 0
18 INT250631 MCTS1 Regulation of Fbxo23 1 1 0.02 0 0
19 INT250634 MCTS1 Positive_regulation of Fbxo23 1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 5 1048 0.78 332.8 394.16
3 INT9381 Positive_regulation of TRPV1 1 523 0.70 187.4 276.05
4 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
5 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
6 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
7 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
8 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
9 INT170025 Gene_expression of Fig4 2 588 0.67 183.27 113.32
10 INT90091 Gene_expression of GOPC 7 967 0.67 366.22 103.6
11 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
12 INT2289 Gene_expression of PENK 2 203 0.78 55.62 79.49
13 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
14 INT1724 Negative_regulation of ACE 6 437 0.59 315.64 74.48
15 INT15913 Negative_regulation of CYP2D6 3 174 0.59 22.45 70.91
16 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
17 INT170332 Gene_expression of IFN1@ 1 477 0.75 275.21 69.65
18 INT8357 Gene_expression of KNG1 3 153 0.75 77.26 68.66
19 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
20 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
21 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
22 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
23 INT20382 Gene_expression of Hand2 2 211 0.66 142.26 51.05
24 INT170646 Negative_regulation of Fig4 1 213 0.37 81.29 46.92
25 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
26 INT173693 Localization of Gopc 1 249 0.65 70.49 38.81
27 INT2416 Negative_regulation of MAOA 1 92 0.59 42.24 36.5
28 INT10796 Gene_expression of CYP2B6 1 131 0.77 30.14 35.27
29 INT3679 Gene_expression of AVP 1 171 0.78 72.9 35.23
30 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
31 INT234 Binding of Alb 5 151 0.48 52.34 32.97
32 INT16290 Gene_expression of BSG 2 60 0.68 38.73 32.86
33 INT7692 Positive_regulation of PENK 2 71 0.70 20.34 32.54
34 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
35 INT610 Regulation of PENK 2 47 0.62 14.17 31.55
36 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
37 INT54302 Positive_regulation of Gene_expression of Il4 1 126 0.68 86.18 30.75
38 INT34729 Positive_regulation of IFN1@ 1 233 0.67 128.04 30.38
39 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
40 INT6855 Binding of NCOR2 1 71 0.41 15.64 28.96
41 INT15610 Localization of GOPC 1 223 0.65 68.26 28.7
42 INT6174 Regulation of Gene_expression of POMC 1 49 0.61 9.75 27.69
43 INT15458 Gene_expression of NPY 1 50 0.76 22.67 23.03
44 INT3330 Gene_expression of AGT 2 149 0.76 98.65 22.73
45 INT7383 Localization of VIP 1 53 0.81 17.7 22.65
46 INT83797 Gene_expression of Bcl2l1 1 124 0.77 94.55 22.39
47 INT84732 Positive_regulation of Hand2 1 81 0.69 62.07 22
48 INT20379 Localization of Il4 1 85 0.73 51.22 20.55
49 INT105021 Binding of GOPC 1 187 0.40 60.39 20.38
50 INT52457 Gene_expression of ABCB1 2 129 0.78 38.68 19.88
51 INT11243 Localization of NPY 1 33 0.78 11.18 19.24
52 INT10565 Gene_expression of MRXS5 1 94 0.53 37.35 19.08
53 INT15470 Regulation of CPP 1 42 0.48 26.1 18.25
54 INT9246 Positive_regulation of Cat 1 113 0.70 52.73 18.04
55 INT23635 Positive_regulation of MMP12 1 31 0.59 28.19 17.95
56 INT133647 Negative_regulation of HDAC9 3 149 0.57 106.84 17.9
57 INT94467 Positive_regulation of Hand1 1 71 0.58 59 16.96
58 INT24225 Gene_expression of Alms1 3 93 0.62 52.75 16.93
59 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
60 INT170754 Localization of IFN1@ 1 121 0.78 66.78 15.6
61 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
62 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
63 INT170335 Gene_expression of INCENP 1 176 0.54 91.62 15.31
64 INT7587 Localization of GAL 1 27 0.78 4.79 14.29
65 INT20665 Gene_expression of ACE 2 87 0.78 51.71 14.19
66 INT36177 Binding of Alms1 6 70 0.31 35.47 13.81
67 INT47909 Binding of CPP 1 32 0.48 24.9 13.79
68 INT5207 Negative_regulation of Alms1 2 70 0.41 41.56 13.68
69 INT142593 Positive_regulation of Tlr2 2 85 0.70 75.9 13.62
70 INT174838 Localization of INCENP 4 80 0.64 19.05 12.89
71 INT35801 Regulation of Alms1 1 34 0.38 20.88 12.38
72 INT107033 Gene_expression of Slc37a4 23 66 0.62 27.34 12.35
73 INT170601 Positive_regulation of Gene_expression of GOPC 1 122 0.43 42.79 11.68
74 INT987 Localization of TRH 2 37 0.78 10.53 11.1
75 INT10009 Positive_regulation of TRH 1 31 0.67 8.94 11.03
76 INT36453 Binding of ABCA1 3 48 0.45 19.9 10.84
77 INT22210 Gene_expression of CYP1A2 2 45 0.78 4.95 10.66
78 INT121796 Gene_expression of NeuN 1 92 0.78 23.18 10.53
79 INT2294 Protein_catabolism of PENK 1 19 1.00 0.64 10.22
80 INT55418 Regulation of CYP2D6 1 29 0.61 1.83 10.21
81 INT29740 Gene_expression of ANG 1 55 0.78 24.53 9.86
82 INT36891 Positive_regulation of Gd 1 39 0.48 34.32 9.43
83 INT95414 Positive_regulation of Alms1 6 40 0.41 20.3 8.1
84 INT15161 Positive_regulation of Localization of VIP 1 12 0.50 3.3 7.87
85 INT177759 Negative_regulation of IFN1@ 1 51 0.57 31.81 7.76
86 INT270 Regulation of MAOA 2 17 0.60 2.58 6.84
87 INT105287 Positive_regulation of Slco1c1 4 24 0.34 15.41 6.81
88 INT12333 Regulation of CYP3A 1 18 0.62 2.25 6.74
89 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
90 INT84965 Gene_expression of MAOA 1 15 0.75 6.9 6.06
91 INT89084 Gene_expression of Slco1c1 3 15 0.51 4.92 6.02
92 INT71764 Positive_regulation of Mri1 2 24 0.44 12.31 5.67
93 INT97692 Positive_regulation of HDAC9 1 17 0.45 14.88 5.11
94 INT68244 Positive_regulation of Ighg1 1 60 0.61 48.86 5.01
95 INT2848 Localization of ABCA1 1 23 0.70 10.64 4.73
96 INT114499 Gene_expression of MCPH1 4 38 0.67 26.68 4.55
97 INT75629 Gene_expression of Mtap2 1 41 0.66 8.19 4.51
98 INT124136 Positive_regulation of YWHAZ 1 7 0.67 1.85 4.51
99 INT83798 Negative_regulation of Gene_expression of Bcl2l1 1 28 0.58 20.26 4.21
100 INT103463 Localization of CPP 3 16 0.66 9.63 4.08
101 INT2934 Gene_expression of Fbxo23 7 9 0.50 1.42 4.02
102 INT1149 Binding of ecs 1 19 0.37 13.67 3.9
103 INT322367 Positive_regulation of NPS 2 2 0.45 0 3.8
104 INT24366 Positive_regulation of Localization of NPY 1 4 0.50 4.01 3.79
105 INT108761 Localization of Alms1 1 24 0.70 13.92 3.74
106 INT173751 Transcription of Fig4 1 31 0.46 8.28 3.7
107 INT28390 Negative_regulation of Mt1a 1 4 0.36 1.13 3.39
108 INT61347 Positive_regulation of Localization of GAL 1 4 0.49 1.06 3.15
109 INT172551 Negative_regulation of INCENP 2 38 0.07 20.83 3.14
110 INT70563 Localization of ABCB1 1 14 0.78 2.03 3.09
111 INT39344 Gene_expression of DNASE1L3 5 12 0.54 2.25 2.88
112 INT187187 Regulation of Gene_expression of BSG 1 3 0.40 3.84 2.8
113 INT68235 Positive_regulation of IgG2a 2 39 0.49 30.96 2.75
114 INT100360 Negative_regulation of TF 1 19 0.42 10.43 2.68
115 INT43719 Positive_regulation of Vegfa 6 21 0.69 5.15 2.64
116 INT169987 Transcription of GOPC 1 45 0.60 21.88 2.61
117 INT136093 Regulation of FBN1 1 10 0.14 4.39 2.52
118 INT43723 Regulation of Vegfa 1 9 0.34 4.96 2.28
119 INT65948 Binding of DNASE1L3 4 8 0.31 1.38 2.21
120 INT173090 Regulation of INCENP 1 24 0.09 9.45 2.16
121 INT250604 Regulation of MCTS1 14 14 0.51 1.2 2.13
122 INT25463 Negative_regulation of Gene_expression of MRXS5 1 7 0.38 4.75 2.12
123 INT86460 Binding of Slc37a4 1 5 0.04 1.8 2.08
124 INT173512 Positive_regulation of Gene_expression of Alms1 1 12 0.44 8.66 1.95
125 INT33096 Negative_regulation of Gene_expression of ACE 1 9 0.43 2.84 1.93
126 INT250599 Gene_expression of MCTS1 28 29 0.64 1.4 1.89
127 INT169483 Positive_regulation of Sema6a 3 6 0.45 6.93 1.74
128 INT64378 Gene_expression of DMRT1 3 9 0.54 1.72 1.71
129 INT235553 Gene_expression of Gvh 1 8 0.48 4.95 1.68
130 INT97062 Binding of PML 2 10 0.41 11.63 1.65
131 INT160181 Regulation of Fbxo23 3 4 0.50 0.63 1.63
132 INT105248 Negative_regulation of Vegfa 1 8 0.47 6.19 1.61
133 INT17885 Negative_regulation of YWHAZ 1 6 0.56 2.74 1.58
134 INT106585 Gene_expression of Rabif 2 4 0.76 0.21 1.58
135 INT30683 Binding of TRH 1 4 0.36 0.96 1.55
136 INT22159 Gene_expression of AMT 2 11 0.75 2.19 1.5
137 INT167815 Gene_expression of Tpi1 2 8 0.65 1.59 1.45
138 INT233943 Binding of Expi 2 3 0.03 0.79 1.33
139 INT58118 Positive_regulation of Slc5a8 3 5 0.50 0.76 1.3
140 INT205952 Gene_expression of Shbdp1 1 14 0.24 2.46 1.27
141 INT250628 Negative_regulation of MCPH1 6 8 0.17 7.05 1.27
142 INT132453 Binding of TF 1 31 0.36 12.98 1.22
143 INT124956 Regulation of IgG2a 1 5 0.34 3.67 1.21
144 INT250622 Binding of MCTS1 3 4 0.40 0.91 1.15
145 INT139679 Positive_regulation of Ighg2b 2 11 0.55 10.57 1.1
146 INT21546 Regulation of ABCA1 1 16 0.40 4.21 1.04
147 INT160180 Positive_regulation of Fbxo23 6 3 0.35 1.7 1.03
148 INT170818 Localization of RASGRP1 1 4 0.44 1.93 1.02
149 INT41315 Localization of Fbxo23 1 4 0.66 0.78 1.01
150 INT342642 Regulation of CTSL1 1 1 0.07 0.19 0.96
151 INT138683 Regulation of Ighg1 1 15 0.30 7.95 0.94
152 INT115845 Positive_regulation of Gene_expression of DNASE1L3 1 2 0.40 0.58 0.9
153 INT157846 Gene_expression of BCS1L 1 13 0.50 15.89 0.83
154 INT114504 Positive_regulation of Scd1 1 10 0.48 3.77 0.8
155 INT243845 Localization of MAOA 1 4 0.55 1.52 0.77
156 INT234820 Localization of AGFG1 1 3 0.14 0.86 0.74
157 INT199812 Localization of CTSL1 1 2 0.30 0.16 0.73
158 INT262726 Localization of PML 1 6 0.57 7.13 0.72
159 INT259902 Regulation of Gene_expression of ACE 1 3 0.45 1.87 0.7
160 INT158836 Positive_regulation of Localization of TRH 2 7 0.49 2.61 0.67
161 INT34769 Regulation of Gene_expression of AGT 1 3 0.19 1.39 0.67
162 INT62773 Gene_expression of RSS 2 9 0.65 4.44 0.62
163 INT97860 Gene_expression of CTSA 1 8 0.43 2.22 0.54
164 INT282809 Negative_regulation of Positive_regulation of YWHAZ 1 1 0.03 1.07 0.52
165 INT192653 Binding of Capns1 1 8 0.26 9.94 0.51
166 INT177610 Positive_regulation of Localization of Fbxo23 1 3 0.04 0.91 0.47
167 INT102181 Negative_regulation of CLTC 1 5 0.37 1.37 0.42
168 INT130966 Binding of EZR 2 2 0.36 0.24 0.41
169 INT156776 Regulation of Slc22a12 1 3 0.25 1.74 0.4
170 INT144533 Gene_expression of Gem 5 4 0.39 5.12 0.39
171 INT250609 Negative_regulation of Negative_regulation of MCPH1 1 1 0.12 1.03 0.39
172 INT187182 Binding of BSG 4 7 0.32 2.83 0.37
173 INT282837 Binding of Slc5a8 3 1 0.42 0.92 0.36
174 INT156280 Gene_expression of Sdc1 2 6 0.43 0.55 0.34
175 INT68567 Negative_regulation of Fbxo23 3 3 0.18 0.82 0.34
176 INT250610 Regulation of Gene_expression of MCTS1 2 1 0.51 0 0.34
177 INT164209 Gene_expression of Slc5a8 18 3 0.77 5.9 0.32
178 INT250603 Negative_regulation of MCTS1 4 1 0.36 0.23 0.32
179 INT282836 Localization of Slco1c1 2 1 0.06 0 0.29
180 INT250618 Negative_regulation of SLC16A4 1 1 0.15 0 0.28
181 INT281933 Localization of YWHAZ 1 2 0.09 1.08 0.27
182 INT164731 Regulation of MCPH1 2 4 0.45 0.5 0.25
183 INT284385 Positive_regulation of Localization of ABCA1 1 2 0.02 0.22 0.25
184 INT129228 Gene_expression of Mcts1 1 2 0.57 0.21 0.22
185 INT250615 Regulation of Gene_expression of MCPH1 1 1 0.45 0 0.2
186 INT250607 Phosphorylation of MCTS1 1 1 0.67 0 0.14
187 INT164204 Negative_regulation of Slc5a8 1 2 0.42 0.22 0.13
188 INT222655 Binding of Sdc1 1 3 0.05 0.64 0.12
189 INT250624 Localization of MCPH1 2 1 0.23 0 0.12
190 INT282845 Localization of Slc5a8 2 1 0.75 1.04 0.11
191 INT282833 Regulation of Binding of TRH 1 1 0.22 0.13 0.11
192 INT250626 Transcription of MCTS1 2 1 0.57 0 0.11
193 INT221193 Gene_expression of mct1 2 2 0.25 0.43 0.1
194 INT282829 Negative_regulation of Kin 2 1 0.57 0 0.1
195 INT282824 Regulation of PML 1 3 0.44 2.66 0.09
196 INT303410 Regulation of Ighg2b 1 2 0.25 1.22 0.09
197 INT303412 Positive_regulation of Regulation of Ighg2b 1 2 0.43 1.23 0.09
198 INT250614 Regulation of SLC16A7 2 1 0.11 0 0.09
199 INT282842 Positive_regulation of Gene_expression of Slc5a8 1 1 0.50 0 0.07
200 INT282834 Gene_expression of OR8I1P 1 1 0.01 0.14 0.07
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