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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT212505 Binding of pr and Lbp 1 5 0.01 4.26 2.62
2 INT245572 Binding of AVPR2 and SPECC1 1 1 0.10 0.75 0.75
3 INT185358 Binding of MCS and PCS 7 3 0.22 3.34 0.57
4 INT348322 Il6 Positive_regulation of Localization of Crp 1 2 0.06 3.51 0.51
5 INT348321 Binding of POMC and ASPM 1 1 0.02 0.39 0.23
6 INT348323 Binding of Crp and Il6 1 1 0.05 0.06 0.03
7 INT325957 Binding of AGRP and TPX2 1 1 0.01 0.17 0
8 INT244401 Binding of HPV6AI1 and HEPACAM 1 2 0.00 4.33 0
9 INT342830 Binding of AGRP and Cd4 1 1 0.13 0.2 0
10 INT325958 Positive_regulation of Binding of AGRP and TPX2 1 1 0.01 0.18 0
11 INT342829 AGRP Positive_regulation of Binding of AGRP and Cd4 1 1 0.15 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 3 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
3 INT16868 Gene_expression of Il6 8 807 0.78 499.48 256.57
4 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
5 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
6 INT15516 Gene_expression of Crp 10 711 0.77 615.33 173.09
7 INT4658 Binding of OPRM1 1 188 0.48 25.96 136.24
8 INT695 Binding of POMC 2 304 0.48 56.66 126.85
9 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
10 INT1026 Binding of Lbp 17 207 0.48 150.96 119.16
11 INT81417 Gene_expression of PAG1 3 94 0.58 90.85 92.79
12 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
13 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
14 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
15 INT3375 Gene_expression of IGHE 1 535 0.77 387.47 65.46
16 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
17 INT9664 Binding of LBP 1 127 0.48 94.9 63.42
18 INT33567 Gene_expression of CALM1 1 139 0.67 48.85 56.14
19 INT1027 Gene_expression of Lbp 4 132 0.77 106.7 54.16
20 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
21 INT1197 Negative_regulation of Localization of POMC 2 109 0.59 28.29 48.02
22 INT1028 Positive_regulation of Lbp 5 102 0.69 67.86 46.05
23 INT2774 Binding of Crp 4 241 0.48 195.89 44.39
24 INT27798 Gene_expression of Ntrk2 2 111 0.78 56.08 42.68
25 INT13556 Gene_expression of CD4 5 367 0.78 230.82 41.74
26 INT9372 Negative_regulation of Lbp 5 86 0.58 46.54 41.71
27 INT5793 Binding of CTS 4 110 0.48 63.91 40.62
28 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
29 INT9094 Gene_expression of COL7A1 3 277 0.77 143.42 38.73
30 INT1624 Gene_expression of Cea 1 212 0.76 180.44 34.21
31 INT894 Binding of Avp 1 84 0.48 29.16 29.63
32 INT32165 Binding of CALM1 1 92 0.48 24.19 29.57
33 INT9650 Gene_expression of LPA 2 141 0.75 104.57 29
34 INT9647 Gene_expression of PROC 3 163 0.65 89.76 26.75
35 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
36 INT1030 Localization of Lbp 4 52 0.74 38.92 24.91
37 INT17275 Gene_expression of HIVEP1 1 267 0.75 232.07 24.06
38 INT9292 Positive_regulation of SGCG 1 93 0.67 35.13 23.48
39 INT4535 Localization of PROC 2 106 0.73 76.24 21.1
40 INT51474 Binding of Il6 7 55 0.48 44.99 20.52
41 INT91648 Binding of SPECC1 17 7 0.48 22.42 19.36
42 INT16445 Gene_expression of IL1A 1 60 0.78 44.46 19.19
43 INT52179 Regulation of Lbp 2 39 0.61 25.4 18.32
44 INT17442 Gene_expression of ALOX5 7 110 0.75 51.55 18.29
45 INT38056 Localization of Crp 2 71 0.78 53.14 17.03
46 INT26972 Negative_regulation of Tenc1 2 57 0.57 56.71 16.87
47 INT7339 Localization of CALM1 1 46 0.75 16.15 16.47
48 INT10721 Gene_expression of BDNF-AS 2 119 0.76 72.8 16.29
49 INT3400 Positive_regulation of pr 1 57 0.68 36.9 16.24
50 INT25493 Gene_expression of TFPI 1 74 0.76 39.44 14.78
51 INT90766 Gene_expression of PCS 6 93 0.77 40.48 14.51
52 INT17035 Positive_regulation of TFPI 1 55 0.61 34.88 14.18
53 INT2673 Negative_regulation of PROC 6 93 0.57 50.34 12.79
54 INT10870 Regulation of IgG 1 67 0.59 43.27 12.74
55 INT8629 Positive_regulation of COL7A1 8 72 0.69 40.66 12.09
56 INT26973 Gene_expression of Tenc1 3 59 0.66 27.19 12
57 INT50933 Transcription of Il6 1 38 0.72 24.31 11.58
58 INT1735 Gene_expression of HSD11B1 1 199 0.75 257.87 11.5
59 INT1108 Gene_expression of PPY 6 58 0.75 36.57 10.76
60 INT39712 Binding of pad 4 82 0.48 110.92 10.33
61 INT110110 Gene_expression of ACCS 1 85 0.58 75.88 10.2
62 INT3180 Positive_regulation of PPY 4 39 0.63 25.57 10.15
63 INT144689 Regulation of RCT 4 49 0.53 25.91 9.6
64 INT57549 Gene_expression of GNPTAB 1 49 0.65 57.5 9.05
65 INT1168 Binding of PROC 1 62 0.38 44.15 9.04
66 INT4534 Regulation of PROC 1 38 0.33 19.81 8.99
67 INT7105 Gene_expression of pad 1 54 0.77 63.68 8.8
68 INT6499 Localization of Ntrk2 3 44 0.79 11.78 8.75
69 INT57057 Gene_expression of APC 2 131 0.78 122.24 8.7
70 INT142694 Positive_regulation of PGAP1 1 3 0.08 2.78 8.68
71 INT939 Gene_expression of PAEP 1 86 0.77 31.02 8.59
72 INT195203 Binding of Tenc1 4 14 0.32 13.97 8.28
73 INT134106 Positive_regulation of SPECC1 7 14 0.68 9.44 8.09
74 INT88868 Binding of MCS 7 45 0.40 37.43 7.98
75 INT72884 Positive_regulation of Tenc1 3 13 0.42 14.01 7.67
76 INT139493 Gene_expression of Scly 1 11 0.57 16.96 7.61
77 INT79168 Binding of TNC 2 39 0.47 16.51 7.55
78 INT147793 Localization of COPD 1 70 0.64 89.01 7.3
79 INT10863 Positive_regulation of Ldlr 1 45 0.68 31.06 7.05
80 INT10228 Positive_regulation of PCS 7 49 0.67 28.72 7
81 INT22781 Binding of COL7A1 1 76 0.48 41.59 6.66
82 INT25022 Binding of PAEP 1 66 0.42 22.83 6.59
83 INT62509 Gene_expression of MCS 6 58 0.67 21.46 6.57
84 INT86805 Localization of HGF 1 49 0.71 28.48 6.35
85 INT47681 Regulation of Ntrk2 1 17 0.62 3.61 6.31
86 INT183910 Negative_regulation of Gene_expression of Lbp 1 10 0.35 9.78 6.15
87 INT80419 Gene_expression of Kdm5d 2 50 0.62 22.49 6.1
88 INT22128 Positive_regulation of HIVEP1 1 61 0.43 70.52 6.07
89 INT178604 Gene_expression of TPX2 3 13 0.37 20.29 6.04
90 INT27118 Regulation of Binding of OPRM1 1 10 0.62 1.18 5.97
91 INT25123 Negative_regulation of COL7A1 2 42 0.58 19.98 5.96
92 INT77955 Negative_regulation of PCS 8 55 0.43 39.32 5.76
93 INT54602 Regulation of MCS 2 22 0.24 10.41 5.75
94 INT134346 Binding of PCS 12 51 0.37 22.27 5.67
95 INT28164 Regulation of ALOX5 1 25 0.60 12.76 5.47
96 INT62510 Positive_regulation of MCS 4 32 0.60 11.79 5.45
97 INT28165 Positive_regulation of ALOX5 5 38 0.47 10.8 5.37
98 INT81796 Binding of AGRP 7 62 0.36 37.19 5.3
99 INT3811 Negative_regulation of PAEP 3 36 0.50 23.7 5.18
100 INT52631 Regulation of M3c 1 13 0.53 7.39 5.17
101 INT60252 Binding of HIVEP1 2 59 0.32 65.12 5.06
102 INT58060 Negative_regulation of HMI 1 30 0.44 11.9 5.06
103 INT156794 Gene_expression of CISH 1 41 0.58 23.09 5.03
104 INT22022 Regulation of PPY 2 8 0.26 5.52 5.02
105 INT71418 Binding of CES1 8 42 0.40 29.78 5.01
106 INT245574 Regulation of SPECC1 5 5 0.44 6.03 5
107 INT59555 Binding of RYR1 4 39 0.42 8.65 4.92
108 INT32256 Gene_expression of PLXNA3 2 11 0.75 7.8 4.92
109 INT45613 Positive_regulation of pad 1 23 0.50 24.18 4.8
110 INT58079 Localization of Tenc1 2 13 0.68 5.9 4.75
111 INT63839 Binding of CRS 2 31 0.41 34.05 4.7
112 INT14831 Negative_regulation of TNC 1 18 0.50 8.71 4.61
113 INT2836 Positive_regulation of PAEP 2 51 0.67 26.69 4.57
114 INT78719 Binding of Ucp1 3 8 0.41 8.93 4.5
115 INT65056 Binding of Ntrk2 3 20 0.36 3.72 4.42
116 INT102187 Gene_expression of SH2B2 1 23 0.59 26.54 4.39
117 INT152616 Gene_expression of SPECC1 1 8 0.66 8.43 4.32
118 INT32569 Localization of GGH 1 18 0.80 2.46 4.3
119 INT141665 Gene_expression of AGRP 2 83 0.67 43.43 4.24
120 INT9349 Gene_expression of BBS2 2 15 0.49 12.77 4.22
121 INT71868 Regulation of Tenc1 1 9 0.52 10.73 4.09
122 INT106805 Localization of ACCS 1 15 0.53 15.22 3.98
123 INT88867 Localization of MCS 2 19 0.62 28.31 3.88
124 INT149259 Gene_expression of RCT 1 38 0.67 15.73 3.87
125 INT172677 Gene_expression of SHE 5 65 0.59 25.86 3.85
126 INT78023 Gene_expression of DDX41 1 13 0.65 23.55 3.84
127 INT58602 Gene_expression of HMI 1 34 0.65 25.26 3.74
128 INT133733 Positive_regulation of Localization of Lbp 1 6 0.43 9.19 3.61
129 INT42243 Positive_regulation of Negative_regulation of Maoa 1 5 0.50 2.15 3.59
130 INT54102 Positive_regulation of Gene_expression of TFPI 1 14 0.49 6.67 3.54
131 INT58643 Positive_regulation of HMI 1 10 0.50 6.59 3.5
132 INT62061 Gene_expression of TRGC1 6 32 0.69 17.43 3.37
133 INT21156 Binding of PLXNA3 9 21 0.36 7.95 3.3
134 INT15648 Positive_regulation of RYR1 3 30 0.67 12.03 3.26
135 INT10476 Binding of ALOX5 7 26 0.36 7.69 3.2
136 INT175262 Binding of SH2B2 2 18 0.36 22.85 3.18
137 INT2837 Regulation of PAEP 1 17 0.53 7.84 3.17
138 INT109411 Gene_expression of SAT1 1 61 0.77 67.99 3.08
139 INT123466 Binding of T2dm2 2 21 0.37 34.87 2.91
140 INT61714 Binding of FGD1 2 12 0.35 7.72 2.91
141 INT33568 Phosphorylation of CALM1 1 10 0.55 2.31 2.91
142 INT239083 Binding of PPY 3 9 0.32 7.59 2.9
143 INT103020 Gene_expression of SGCA 3 22 0.56 14.29 2.75
144 INT27652 Gene_expression of TG 1 36 0.78 22.36 2.74
145 INT179428 Binding of FANCE 3 5 0.34 3.65 2.74
146 INT53020 Positive_regulation of ACSM3 1 9 0.58 11.03 2.73
147 INT178606 Positive_regulation of Gene_expression of TPX2 1 4 0.08 8.73 2.71
148 INT181267 Gene_expression of USE1 1 12 0.32 7.6 2.7
149 INT21775 Gene_expression of crf 2 8 0.54 4.96 2.7
150 INT29879 Positive_regulation of GGH 1 9 0.70 3.13 2.62
151 INT82966 Transcription of Crp 1 14 0.70 9.91 2.61
152 INT185407 Binding of PER1 1 13 0.42 9.32 2.6
153 INT45612 Negative_regulation of pad 1 8 0.37 6.74 2.57
154 INT188756 Positive_regulation of AGRP 1 43 0.60 23.67 2.51
155 INT3410 Positive_regulation of Artles 1 9 0.04 2.57 2.5
156 INT1928 Negative_regulation of Lpl 3 18 0.51 11.22 2.49
157 INT2405 Negative_regulation of SGCA 1 15 0.57 6.04 2.45
158 INT210527 Positive_regulation of Gene_expression of Tenc1 1 14 0.38 6.37 2.45
159 INT329080 Positive_regulation of Gene_expression of Scly 1 4 0.43 6.3 2.43
160 INT183668 Binding of SGCA 1 15 0.36 9.86 2.42
161 INT197196 Negative_regulation of DURS1 1 2 0.43 30.6 2.37
162 INT62511 Negative_regulation of MCS 1 20 0.50 6.77 2.35
163 INT182720 Binding of SHE 3 18 0.26 9.15 2.24
164 INT56375 Positive_regulation of AMBP 1 25 0.60 21.24 2.22
165 INT65948 Binding of DNASE1L3 1 8 0.31 1.38 2.21
166 INT7106 Regulation of pad 1 8 0.27 5.24 2.16
167 INT47780 Gene_expression of CREM 4 17 0.74 5.37 2.13
168 INT104006 Binding of Kdm5d 1 26 0.26 8.09 2.07
169 INT115782 Gene_expression of KCND3 2 4 0.33 1.85 2.07
170 INT150384 Binding of RCT 3 10 0.25 3.1 2.05
171 INT6508 Gene_expression of RYR1 12 34 0.77 11.11 2.04
172 INT83468 Gene_expression of ELK3 2 22 0.66 2.91 2.03
173 INT125451 Gene_expression of CLDN4 1 5 0.78 4.75 2.01
174 INT122924 Binding of ipv 10 27 0.42 31.81 1.99
175 INT145937 Regulation of PCS 4 32 0.39 19.25 1.97
176 INT123843 Gene_expression of soc 3 14 0.58 5.22 1.96
177 INT195817 Gene_expression of ipv 7 28 0.58 31.04 1.86
178 INT245573 Negative_regulation of Binding of SPECC1 2 1 0.43 2.15 1.8
179 INT33400 Regulation of CDS1 1 8 0.29 5.12 1.79
180 INT82918 Binding of AMBP 1 23 0.39 23.31 1.71
181 INT8345 Negative_regulation of FRTS 2 10 0.42 2.8 1.7
182 INT16622 Positive_regulation of PLXNA3 4 6 0.67 5.2 1.69
183 INT62712 Negative_regulation of HGF 1 19 0.58 7.21 1.67
184 INT241610 Binding of Tcam1 6 1 0.28 5.31 1.67
185 INT162726 Localization of RCT 2 12 0.58 4.53 1.66
186 INT176629 Gene_expression of GREM1 1 9 0.10 6.89 1.66
187 INT11713 Localization of RYR1 7 22 0.76 10.42 1.64
188 INT81726 Binding of soc 27 42 0.42 9.92 1.61
189 INT211853 Phosphorylation of Tenc1 1 2 0.61 2.53 1.59
190 INT211136 Localization of USE1 2 3 0.11 2.67 1.57
191 INT99720 Positive_regulation of SAT1 1 21 0.69 26.55 1.56
192 INT83429 Binding of FRTS 2 8 0.42 5.46 1.52
193 INT160283 Localization of NHS 1 7 0.65 2.48 1.52
194 INT167070 Positive_regulation of Gene_expression of MCS 1 3 0.30 3.75 1.48
195 INT144341 Binding of Qrfpr 6 4 0.36 0.89 1.4
196 INT112655 Negative_regulation of PAM 1 3 0.57 0.97 1.39
197 INT134338 Gene_expression of CD55 1 23 0.65 13.01 1.38
198 INT8068 Gene_expression of RASGRP1 1 29 0.54 15.1 1.37
199 INT46848 Positive_regulation of TPX2 2 9 0.70 5.01 1.35
200 INT139107 Localization of SPECC1 1 3 0.71 1.45 1.35
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