J:Cancer management and research

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 2 0.52 12.7 7.73
2 INT194647 Binding of CD28 and CD80 15 1 0.40 4.9 3.22
3 INT186126 Binding of CD28 and CTLA4 9 1 0.52 4.13 3.12
4 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 1 0.00 0.8 0.58
5 INT351007 Binding of IL2 and IL2RA 1 2 0.33 1.33 0.26
6 INT351143 Binding of Cd3e and Ighg2a 1 2 0.00 1.56 0.25
7 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 1 0.10 0.75 0.19
8 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 1 0.04 0.74 0.19
9 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 1 0.17 0.66 0.18
10 INT351144 Binding of Ighg2b and Ighg2a 1 1 0.00 0.78 0.12
11 INT351032 Binding of CD80 and CD96 1 1 0.01 0.36 0.09
12 INT351031 Binding of CD28 and CD96 1 1 0.02 0.36 0.09
13 INT351011 Binding of HDAC9 and TSPYL2 1 1 0.04 0.63 0.08
14 INT351142 Binding of Cd3e and Ighg2b 1 1 0.03 0.6 0.07
15 INT351001 Binding of Adh7 and Ins1 1 1 0.00 1.62 0.05
16 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 1 0.31 0.46 0.05
17 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 1 0.27 0.44 0.05
18 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 1 0.10 0.42 0.05
19 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 1 0.18 0.42 0.05
20 INT213903 Binding of EGFR and ERBB2 10 1 0.37 5.03 0.04
21 INT287268 Binding of ERBB2 and ERBB3 5 1 0.16 2.74 0
22 INT294088 Binding of ERBB2 and ERBB4 2 1 0.13 0.88 0
23 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 1 0.04 0.33 0
24 INT351155 AKT1 Positive_regulation of Positive_regulation of FGF2 1 1 0.03 0.81 0
25 INT351167 CAV1 Negative_regulation of Ppp2r1a 1 2 0.08 1.5 0
26 INT351099 EPAS1 Regulation of Gene_expression of CRTC1 1 1 0.00 0.8 0
27 INT350981 VHL Regulation of XRCC1 1 1 0.01 1.42 0
28 INT351029 AGK Regulation of VEGFA 1 1 0.00 0.82 0
29 INT351166 Gtf3a Positive_regulation of Gene_expression of CAV1 1 1 0.01 0.79 0
30 INT351156 VEGFA Positive_regulation of Gene_expression of CAV1 1 1 0.07 0.79 0
31 INT351013 PROK1 Regulation of ISG20 1 1 0.01 0.76 0
32 INT350984 Positive_regulation of VHL Positive_regulation of VEGFA 1 2 0.27 2.74 0
33 INT350983 TP53 Regulation of VEGFA 1 1 0.03 0.61 0
34 INT351097 RRAD Negative_regulation of EIF4EBP1 1 1 0.00 0 0
35 INT351165 Binding of CAV1 and Nos3 1 2 0.09 1.46 0
36 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 1 0.01 1.43 0
37 INT351093 RRAD Regulation of RRAD Negative_regulation of EIF4EBP1 1 1 0.00 0 0
38 INT351100 RRAD Regulation of EIF4EBP1 1 1 0.00 0 0
39 INT351164 CAV1 Negative_regulation of Ppp1cc 1 2 0.11 1.5 0
40 INT350982 TSHB Regulation of VEGFA 1 1 0.01 0.64 0
41 INT351098 MTOR Regulation of Binding of EPAS1 1 1 0.08 0.95 0
42 INT351158 CAV1 Regulation of SRC 1 1 0.01 0.68 0
43 INT350980 ESR1 Regulation of VEGFA 1 1 0.01 0.62 0
44 INT351030 AGK Regulation of ARAF 1 1 0.00 0.82 0
45 INT351095 Binding of FKBP1A and RPS6KB1 1 1 0.24 0.36 0
46 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 1 0.27 0.36 0
47 INT351159 CAV1 Positive_regulation of AKT1 1 1 0.11 0.87 0
48 INT351002 Binding of Adh7 and Mrgpre 1 5 0.00 3.65 0
49 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 1 0.04 0.35 0
50 INT351094 RRAD Negative_regulation of RRAD Regulation of EIF4EBP1 1 1 0.00 0 0
51 INT351096 Binding of FKBP1A and MTOR 1 3 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
4 INT68684 Gene_expression of VEGFA 8 2371 0.78 1742.52 259.2
5 INT5116 Gene_expression of IL2 6 670 0.78 291.13 146.69
6 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
7 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
8 INT7395 Localization of GNRH1 2 399 0.81 62.88 117.68
9 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
10 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
11 INT68682 Positive_regulation of VEGFA 4 640 0.70 454.14 81.65
12 INT920 Localization of PLOD1 3 223 0.81 42.25 78.7
13 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
14 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
15 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
16 INT170332 Gene_expression of IFN1@ 19 477 0.75 275.21 69.65
17 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
18 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
19 INT546 Binding of ALB 1 311 0.48 85.98 60.14
20 INT52264 Gene_expression of IK 1 180 0.77 90.87 51.87
21 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
22 INT80124 Negative_regulation of VEGFA 11 450 0.58 311.19 44.53
23 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
24 INT3933 Positive_regulation of PLOD1 2 128 0.70 30.76 42.03
25 INT61619 Gene_expression of IL12A 1 194 0.77 146.07 41.97
26 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
27 INT77307 Gene_expression of Bcl2 1 399 0.77 319.77 38
28 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
29 INT101992 Localization of VEGFA 9 413 0.81 258.23 36.15
30 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
31 INT6105 Positive_regulation of IL2 2 133 0.69 82.76 34.67
32 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
33 INT10248 Gene_expression of KRT20 2 436 0.78 231.96 32.88
34 INT5868 Positive_regulation of GNRH1 1 122 0.69 20.96 32.8
35 INT48693 Regulation of VEGFA 4 268 0.62 191.88 31.52
36 INT34729 Positive_regulation of IFN1@ 5 233 0.67 128.04 30.38
37 INT28361 Gene_expression of TP53 1 443 0.78 384.86 28.8
38 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
39 INT5135 Negative_regulation of GNRH1 2 106 0.58 36.63 27.71
40 INT1638 Negative_regulation of PLOD1 6 92 0.59 21.69 26.61
41 INT11159 Gene_expression of EGFR 22 698 0.78 548.93 25.69
42 INT72370 Gene_expression of Timp1 1 82 0.65 57.52 24.16
43 INT5131 Gene_expression of GNRH1 2 109 0.78 28.79 23.94
44 INT917 Positive_regulation of Localization of PLOD1 1 51 0.69 8.53 22.87
45 INT48692 Binding of VEGFA 11 345 0.48 210.3 21.31
46 INT11157 Binding of EGF 1 88 0.48 53.73 21.25
47 INT4535 Localization of PROC 4 106 0.73 76.24 21.1
48 INT52457 Gene_expression of ABCB1 1 129 0.78 38.68 19.88
49 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
50 INT86187 Positive_regulation of AKT1 6 199 0.69 122.13 19.44
51 INT192409 Positive_regulation of Gene_expression of IFN1@ 3 102 0.67 64.66 18.8
52 INT4420 Positive_regulation of GOT1 1 103 0.64 88.4 18.38
53 INT14724 Negative_regulation of CYP19A1 1 233 0.59 96.56 18.26
54 INT1642 Negative_regulation of Localization of PLOD1 1 40 0.58 10.67 17.95
55 INT133647 Negative_regulation of HDAC9 2 149 0.57 106.84 17.9
56 INT68681 Transcription of VEGFA 3 132 0.71 80.47 17.03
57 INT13510 Gene_expression of ERBB2 30 530 0.78 405.68 16.79
58 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
59 INT170754 Localization of IFN1@ 8 121 0.78 66.78 15.6
60 INT97245 Gene_expression of AKT1 1 217 0.77 119.63 15.59
61 INT912 Localization of FSHR 2 91 0.79 23.61 15.58
62 INT7970 Gene_expression of PLOD1 6 120 0.71 44.42 15.54
63 INT26538 Positive_regulation of FSHR 1 103 0.69 30.95 15.33
64 INT172171 Gene_expression of IL15 1 47 0.37 46.23 13.41
65 INT86383 Negative_regulation of EGFR 14 258 0.59 173.94 13.32
66 INT61624 Positive_regulation of Gene_expression of IL12A 1 50 0.56 33.07 13.07
67 INT4145 Gene_expression of FSHR 6 124 0.77 44.98 13.04
68 INT27242 Gene_expression of PGR 3 153 0.75 98.77 12.79
69 INT2673 Negative_regulation of PROC 3 93 0.57 50.34 12.79
70 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
71 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
72 INT89395 Negative_regulation of AKT1 2 127 0.58 70.27 12.54
73 INT7234 Binding of GNRH1 4 43 0.47 21.59 12.36
74 INT79545 Positive_regulation of Gene_expression of ESR1 2 82 0.64 39.42 12.18
75 INT148207 Gene_expression of CTLA4 2 53 0.77 29.13 12.07
76 INT19795 Positive_regulation of EGFR 4 161 0.70 103.69 11.55
77 INT65009 Gene_expression of HTR3A 1 29 0.75 8.51 10.59
78 INT15804 Gene_expression of ISG20 5 83 0.75 44.33 10.58
79 INT5788 Gene_expression of IL2RA 9 60 0.75 40.67 9.98
80 INT170333 Binding of IFN1@ 18 68 0.47 49.01 9.72
81 INT70134 Negative_regulation of TXK 4 124 0.23 81.96 9.59
82 INT20664 Binding of ACE 1 60 0.48 35.27 9.16
83 INT1647 Negative_regulation of FSHR 2 54 0.45 13.44 8.87
84 INT119831 Gene_expression of PTEN 1 55 0.75 40.37 8.57
85 INT22383 Binding of IL2 4 59 0.48 39.06 8.56
86 INT81777 Negative_regulation of Gene_expression of IK 1 22 0.08 11.55 8.09
87 INT846 Positive_regulation of B2M 2 42 0.70 29.78 8.06
88 INT53487 Gene_expression of TSC1 1 81 0.58 77.71 7.94
89 INT80220 Positive_regulation of Bcl2 1 71 0.58 57.73 7.86
90 INT177759 Negative_regulation of IFN1@ 2 51 0.57 31.81 7.76
91 INT10284 Binding of ORM1 1 16 0.48 0.98 7.73
92 INT77306 Negative_regulation of Gene_expression of Bcl2 1 46 0.58 38.05 7.71
93 INT78320 Gene_expression of EPCAM 6 57 0.75 50.34 7.53
94 INT96994 Phosphorylation of EGFR 1 99 0.82 52.75 7.33
95 INT16268 Binding of HTR3A 1 15 0.47 7.38 7.18
96 INT44920 Negative_regulation of IK 1 18 0.41 9.9 7.16
97 INT11747 Positive_regulation of IL2RA 1 22 0.67 16.55 6.95
98 INT8101 Binding of INCENP 1 42 0.31 16.2 6.68
99 INT17618 Gene_expression of B2M 1 36 0.66 16.39 6.68
100 INT38672 Binding of KRT20 3 69 0.39 48.01 6.31
101 INT11154 Binding of EGFR 7 149 0.48 96.23 6.29
102 INT11814 Positive_regulation of Alb 1 43 0.63 31.71 6.28
103 INT27628 Gene_expression of IL2RG 1 28 0.75 20.95 6.16
104 INT27591 Negative_regulation of Gene_expression of Alb 1 30 0.58 17.03 5.99
105 INT38671 Positive_regulation of KRT20 1 62 0.53 40.17 5.6
106 INT38670 Positive_regulation of Gene_expression of KRT20 1 68 0.69 23.25 5.55
107 INT125066 Negative_regulation of HDAC4 1 56 0.49 41.55 5.42
108 INT76313 Gene_expression of CD38 3 30 0.64 20.74 5.27
109 INT15376 Positive_regulation of Gene_expression of ERBB2 15 215 0.70 168.54 5.23
110 INT24080 Negative_regulation of Mtor 2 64 0.37 41.56 5.19
111 INT97905 Positive_regulation of FGF2 1 33 0.70 26.74 5.17
112 INT97692 Positive_regulation of HDAC9 1 17 0.45 14.88 5.11
113 INT1317 Negative_regulation of Sds 2 23 0.48 6.97 5.03
114 INT11158 Positive_regulation of Gene_expression of EGFR 8 165 0.70 131.26 4.93
115 INT29327 Positive_regulation of Ace 1 13 0.67 8.79 4.33
116 INT51898 Binding of PECAM1 1 26 0.36 18.87 4.22
117 INT15802 Positive_regulation of Gene_expression of ISG20 1 16 0.42 8.16 4.03
118 INT80421 Positive_regulation of IFI27 2 26 0.65 15.32 3.93
119 INT153666 Gene_expression of CAV1 41 156 0.77 120.99 3.9
120 INT85843 Negative_regulation of BPI 1 5 0.35 5.13 3.77
121 INT170528 Negative_regulation of Gene_expression of CD4 1 25 0.41 17.98 3.6
122 INT18920 Binding of Egf 1 24 0.48 9.43 3.57
123 INT1646 Negative_regulation of Localization of FSHR 1 17 0.58 7.36 3.46
124 INT163832 Negative_regulation of Gene_expression of EGFR 1 50 0.59 39.71 3.45
125 INT79270 Gene_expression of MKI67 1 113 0.77 63.52 3.38
126 INT10353 Positive_regulation of PGR 2 34 0.70 21.84 3.28
127 INT36286 Binding of Cd3e 1 33 0.36 10.11 3.21
128 INT117348 Regulation of EGFR 5 75 0.61 47.73 3.09
129 INT192676 Binding of PTEN 3 14 0.46 10.58 3.06
130 INT130603 Binding of Timp1 1 9 0.35 8.52 3.04
131 INT25031 Negative_regulation of Gene_expression of PLOD1 1 14 0.54 3.86 2.89
132 INT209033 Positive_regulation of Localization of IFN1@ 1 27 0.67 12.55 2.84
133 INT41721 Negative_regulation of MTOR 8 40 0.58 32.49 2.83
134 INT184477 Negative_regulation of Pten 1 27 0.59 15.61 2.8
135 INT89397 Positive_regulation of PIK3CA 1 33 0.67 16.98 2.78
136 INT90875 Negative_regulation of CCND1 1 31 0.42 26.22 2.66
137 INT10795 Positive_regulation of CD59 1 9 0.36 2.11 2.52
138 INT119838 Positive_regulation of PTEN 2 25 0.67 21.71 2.5
139 INT97479 Gene_expression of Tks 1 11 0.52 3.66 2.44
140 INT118791 Binding of AKT1 3 32 0.48 15.51 2.25
141 INT60279 Gene_expression of VHL 5 70 0.78 75.21 2.21
142 INT219180 Gene_expression of TLR7 1 13 0.68 9.51 2.21
143 INT38674 Regulation of KRT20 3 32 0.44 19 2.15
144 INT7972 Positive_regulation of Gene_expression of PLOD1 2 15 0.42 5.73 1.96
145 INT43084 Binding of Ace 1 10 0.46 4.7 1.93
146 INT76532 Binding of Nos3 1 13 0.37 9.32 1.87
147 INT48792 Regulation of ERBB2 5 48 0.57 36.56 1.8
148 INT182899 Transcription of IFN1@ 1 17 0.69 4.91 1.75
149 INT196158 Binding of NRP2 2 16 0.06 7.03 1.73
150 INT25163 Positive_regulation of Gene_expression of IL2RA 1 8 0.45 5.37 1.71
151 INT200223 Positive_regulation of EPAS1 1 21 0.17 21.95 1.7
152 INT97108 Phosphorylation of IL2 1 5 0.73 2.47 1.7
153 INT21788 Positive_regulation of ERBB2 2 49 0.66 28.88 1.68
154 INT157357 Binding of IL2RA 3 6 0.44 5.18 1.63
155 INT118292 Negative_regulation of Phosphorylation of EGFR 1 27 0.59 13.62 1.54
156 INT120519 Localization of XRCC1 1 15 0.78 17.03 1.51
157 INT19109 Positive_regulation of CYP3A5 1 7 0.67 1.48 1.51
158 INT52962 Binding of ERBB2 8 77 0.47 50.03 1.49
159 INT167085 Negative_regulation of ERBB2 15 67 0.57 44.6 1.48
160 INT119520 Gene_expression of TXK 2 19 0.19 17.54 1.45
161 INT41719 Gene_expression of MTOR 4 27 0.77 19.43 1.44
162 INT96838 Negative_regulation of Gene_expression of ERBB2 1 25 0.57 15.83 1.34
163 INT199567 Binding of Kdr 2 18 0.47 13.81 1.34
164 INT1651 Positive_regulation of Negative_regulation of PLOD1 1 4 0.46 0.49 1.33
165 INT127725 Negative_regulation of Positive_regulation of EGFR 1 6 0.57 2.69 1.3
166 INT95116 Negative_regulation of PDGFA 2 24 0.57 19.56 1.29
167 INT190335 Negative_regulation of Positive_regulation of IFN1@ 1 16 0.42 4.6 1.29
168 INT297709 Positive_regulation of Gene_expression of Ucp3 2 5 0.56 4.67 1.28
169 INT136991 Localization of HBEGF 1 5 0.59 3.62 1.28
170 INT230086 Negative_regulation of Localization of IFN1@ 4 9 0.57 6.06 1.25
171 INT22067 Positive_regulation of IL2RB 1 11 0.70 5.74 1.23
172 INT25032 Negative_regulation of Gene_expression of FSHR 1 11 0.39 1.99 1.2
173 INT82547 Negative_regulation of Gene_expression of ISG20 1 7 0.29 3.04 1.18
174 INT78319 Binding of EPCAM 1 8 0.36 10.12 1.14
175 INT212093 Positive_regulation of CASP2 1 6 0.17 6.87 1.14
176 INT216858 Negative_regulation of PID1 1 4 0.35 6.3 1.11
177 INT74020 Negative_regulation of XRCC1 1 16 0.35 17.18 1.06
178 INT22830 Negative_regulation of Binding of IL2 1 4 0.55 4.8 1.06
179 INT172529 Negative_regulation of Gene_expression of PGR 1 24 0.48 16.69 1.04
180 INT42210 Positive_regulation of TSHB 1 6 0.49 3.48 1.01
181 INT193069 Positive_regulation of Gene_expression of CD38 2 4 0.15 4.06 1.01
182 INT112717 Negative_regulation of Binding of VEGFA 1 21 0.56 11.07 0.99
183 INT147464 Binding of Ptprc 1 13 0.36 15.18 0.98
184 INT11160 Regulation of Gene_expression of EGFR 1 27 0.62 22.05 0.96
185 INT250708 Negative_regulation of PIK3CB 1 17 0.30 3.09 0.94
186 INT230251 Binding of FKBP1A 1 6 0.28 2.24 0.94
187 INT153670 Positive_regulation of Gene_expression of CAV1 23 26 0.69 44.27 0.92
188 INT213917 Negative_regulation of Phosphorylation of ERBB2 3 9 0.54 8.68 0.91
189 INT82795 Binding of MYC 1 16 0.47 6.1 0.9
190 INT206699 Positive_regulation of Binding of IFN1@ 1 6 0.49 3.75 0.88
191 INT174516 Regulation of Gene_expression of ISG20 1 6 0.27 4.2 0.85
192 INT71649 Localization of ERBB2 4 23 0.78 13.63 0.83
193 INT211488 Regulation of Binding of VEGFA 1 5 0.43 3.72 0.83
194 INT173100 Binding of KDR 1 39 0.39 22.48 0.81
195 INT176588 Phosphorylation of ERBB2 3 27 0.78 16.37 0.81
196 INT173082 Positive_regulation of Binding of VEGFA 2 20 0.48 11.16 0.79
197 INT297724 Gene_expression of Ucp3 1 13 0.63 10.67 0.79
198 INT171096 Transcription of PDGFA 2 5 0.47 4.42 0.79
199 INT70818 Negative_regulation of Adh7 1 2 0.16 1.04 0.79
200 INT221508 Phosphorylation of IFN1@ 6 14 0.79 8.97 0.77
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