J:Clin. Sci.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT132862 Ngf Positive_regulation of Bdnf 4 1 0.46 4.05 3.65
2 INT132863 Positive_regulation of Ngf Positive_regulation of Bdnf 1 1 0.23 1.11 0.43
3 INT41612 Tac1 Regulation of Localization of Sst 1 1 0.02 0 0.39
4 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 1 0.01 0.35 0.24
5 INT55902 Negative_regulation of Pla2g1b Negative_regulation of Localization of Ptafr 1 1 0.11 0.35 0.24
6 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 1 0.01 0.35 0.24

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
2 INT50058 Negative_regulation of Cpox 1 907 0.58 426.28 428.29
3 INT467 Gene_expression of POMC 7 1048 0.78 332.8 394.16
4 INT720 Positive_regulation of POMC 3 807 0.70 237.37 353.83
5 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
6 INT1005 Localization of Sst 3 385 0.81 26.31 244.56
7 INT738 Regulation of POMC 7 459 0.62 111.19 243.74
8 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
9 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
10 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
11 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
12 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
13 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
14 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
15 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
16 INT915 Positive_regulation of PRL 3 342 0.70 141.96 104.31
17 INT10272 Gene_expression of Il1b 3 194 0.78 121.02 103.03
18 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
19 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
20 INT67682 Localization of Bdnf 1 204 0.81 72.36 88.92
21 INT914 Positive_regulation of GH1 1 292 0.69 100.7 84.91
22 INT5617 Localization of Nppa 1 266 0.81 83.51 83.89
23 INT4631 Positive_regulation of Sst 1 127 0.70 17.37 83.29
24 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
25 INT2893 Localization of Oxt 3 219 0.80 28.96 79.43
26 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
27 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
28 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
29 INT3034 Localization of Ngf 2 126 0.81 50.81 72.84
30 INT7344 Gene_expression of TAC1 2 132 0.75 35.48 68.26
31 INT253 Regulation of PRL 3 184 0.62 47.27 65.79
32 INT7280 Positive_regulation of Localization of Sst 1 97 0.70 5.64 63.37
33 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
34 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
35 INT1579 Gene_expression of PRL 2 279 0.78 119.2 55.41
36 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
37 INT5118 Regulation of SST 1 97 0.62 34.35 51.74
38 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
39 INT17915 Gene_expression of Insr 1 141 0.75 47.45 48.59
40 INT7059 Regulation of Adra2a 1 89 0.62 18.24 48.43
41 INT375 Positive_regulation of REN 4 293 0.70 152.46 47.55
42 INT19078 Binding of Ngf 2 78 0.48 31.03 44.33
43 INT69992 Negative_regulation of Hmox2 1 93 0.50 49.01 44.07
44 INT47683 Negative_regulation of Bdnf 1 92 0.59 47.53 43.55
45 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
46 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
47 INT5539 Negative_regulation of Mme 2 75 0.59 28.91 41.84
48 INT957 Positive_regulation of GHRH 2 136 0.70 36.84 40.52
49 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
50 INT49 Negative_regulation of Ren 1 129 0.59 37.48 35.62
51 INT7608 Positive_regulation of Adra2a 1 66 0.70 17.81 35.15
52 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
53 INT7133 Negative_regulation of MME 3 85 0.59 29.22 33.1
54 INT234 Binding of Alb 1 151 0.48 52.34 32.97
55 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
56 INT9347 Localization of Il1b 5 58 0.81 26.13 31.53
57 INT5069 Negative_regulation of Mthfs 2 69 0.57 22.54 31.36
58 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
59 INT1158 Regulation of Agt 2 106 0.61 29.4 30.29
60 INT6196 Regulation of Nppa 1 83 0.62 30.31 30.18
61 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
62 INT5653 Positive_regulation of ELANE 1 136 0.70 72.78 27.94
63 INT6174 Regulation of Gene_expression of POMC 2 49 0.61 9.75 27.69
64 INT2609 Localization of ELANE 2 111 0.81 50.22 26.63
65 INT10273 Positive_regulation of Gene_expression of Il1b 1 47 0.68 31.15 26.21
66 INT76095 Positive_regulation of ISYNA1 1 117 0.55 79.73 25.86
67 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
68 INT250 Regulation of GHRH 1 65 0.61 17.46 23.19
69 INT956 Negative_regulation of PRL 2 94 0.59 42.72 23.01
70 INT9282 Gene_expression of HTR1B 2 48 0.75 12.15 22.94
71 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
72 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
73 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
74 INT2978 Gene_expression of Tbxa2r 1 76 0.77 28.4 21.27
75 INT11161 Gene_expression of HLA-DRB1 2 121 0.78 75.33 20.96
76 INT3593 Gene_expression of ADRA1D 2 70 0.75 29.48 20.87
77 INT2894 Negative_regulation of Localization of Oxt 1 43 0.58 4.59 20.85
78 INT5160 Localization of PTAFR 1 61 0.80 42.6 19.16
79 INT12360 Regulation of Tac1 1 31 0.61 5.9 18
80 INT5618 Regulation of Localization of Nppa 1 36 0.62 13.42 17.46
81 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
82 INT61949 Regulation of Nos2 1 74 0.58 34.08 16.7
83 INT117500 Gene_expression of Adipoq 2 90 0.74 67.79 16.58
84 INT129 Localization of OXTR 3 51 0.80 11.08 15.36
85 INT10340 Regulation of Localization of Oxt 2 30 0.60 2.55 14.3
86 INT22276 Gene_expression of TBXA2R 3 65 0.77 23.22 14.21
87 INT110 Regulation of Adrb3 1 33 0.60 8.09 13.84
88 INT13409 Gene_expression of NEUROD1 1 52 0.75 14.17 12.23
89 INT48335 Negative_regulation of NOSTRIN 2 38 0.56 16.22 12.05
90 INT70905 Positive_regulation of EDNRA 3 49 0.67 24.33 11.79
91 INT13303 Positive_regulation of PTAFR 1 40 0.69 16.27 11.56
92 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
93 INT17826 Positive_regulation of Pla2g1b 1 39 0.70 11.35 10.97
94 INT1708 Gene_expression of OXTR 5 56 0.78 6.92 10.69
95 INT6574 Negative_regulation of Pla2g1b 1 35 0.59 11.4 10.44
96 INT59465 Negative_regulation of ISYNA1 1 41 0.49 21.9 9.46
97 INT18830 Localization of TBXA2R 5 25 0.81 7.14 9.28
98 INT76405 Positive_regulation of Hmox2 1 21 0.43 12.77 8.99
99 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
100 INT30382 Negative_regulation of Ednra 1 21 0.42 12.06 8.19
101 INT953 Positive_regulation of Positive_regulation of GHRH 2 17 0.67 2.38 8.18
102 INT82450 Negative_regulation of Hmox1 1 33 0.55 19.07 8.12
103 INT4487 Positive_regulation of Positive_regulation of PRL 1 27 0.70 8.06 8.09
104 INT846 Positive_regulation of B2M 2 42 0.70 29.78 8.06
105 INT62944 Regulation of Icam1 2 33 0.47 23.52 7.94
106 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
107 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
108 INT22275 Negative_regulation of TBXA2R 1 25 0.54 8.67 7.34
109 INT47994 Negative_regulation of Lipg 2 45 0.50 27.19 7.24
110 INT132860 Binding of BDNF 2 33 0.47 14.7 6.99
111 INT48954 Positive_regulation of Localization of Il1b 2 13 0.53 8.16 6.44
112 INT11826 Positive_regulation of LDLR 2 62 0.62 45.09 6.21
113 INT6098 Binding of NEUROD1 1 17 0.47 3.4 5.99
114 INT15143 Protein_catabolism of MME 2 16 1.00 4.56 5.54
115 INT70907 Negative_regulation of EDNRA 1 30 0.36 19.68 5.49
116 INT29290 Regulation of Gene_expression of PRL 1 13 0.49 6.46 5.23
117 INT117499 Negative_regulation of Adipoq 1 28 0.56 24.15 5.07
118 INT12474 Regulation of INSRR 1 18 0.29 6.29 4.81
119 INT25056 Regulation of Hmmr 1 6 0.37 2.19 4.54
120 INT10896 Regulation of PTAFR 1 16 0.61 4.22 4.5
121 INT34720 Positive_regulation of SHBG 1 58 0.69 32.4 3.83
122 INT54701 Localization of Ptafr 1 19 0.49 18.68 3.82
123 INT10168 Positive_regulation of Localization of Gtf3a 1 16 0.60 3.55 3.75
124 INT20011 Regulation of NEUROD1 1 10 0.44 3.83 3.53
125 INT22891 Positive_regulation of Localization of ELANE 1 16 0.69 11.52 3.42
126 INT16626 Positive_regulation of Adrb2 1 10 0.30 2.41 3.4
127 INT19206 Regulation of Gene_expression of OXTR 3 5 0.62 0.58 2.96
128 INT12812 Regulation of Hrh3 2 10 0.51 1.07 2.95
129 INT16949 Negative_regulation of CLPP 1 8 0.49 2.47 2.83
130 INT64464 Gene_expression of Reg3b 2 4 0.77 10.95 2.77
131 INT25128 Gene_expression of Mthfs 1 9 0.25 2.38 2.75
132 INT18871 Regulation of Asap1 2 18 0.43 6.49 2.6
133 INT99550 Regulation of FLNA 1 51 0.54 27.88 2.58
134 INT49218 Negative_regulation of Localization of TBXA2R 2 5 0.59 0.32 2.58
135 INT17857 Negative_regulation of Gene_expression of AGT 1 25 0.46 21.16 2.45
136 INT61039 Localization of Ltb4r 2 7 0.59 9.51 2.44
137 INT30857 Binding of OXTR 1 10 0.48 2.27 2.42
138 INT17243 Positive_regulation of Gene_expression of Tbxa2r 1 7 0.55 4.7 2.37
139 INT68087 Regulation of Vwf 1 9 0.39 8.06 2.36
140 INT26363 Negative_regulation of CS 1 8 0.26 2.49 2.36
141 INT4715 Positive_regulation of Xdh 2 20 0.69 6.57 2.28
142 INT122561 Negative_regulation of Gene_expression of Adipoq 1 12 0.56 14.02 2.26
143 INT55897 Positive_regulation of C4a 1 8 0.29 3.81 2.07
144 INT21782 Negative_regulation of B2M 1 11 0.46 5.49 1.92
145 INT17399 Positive_regulation of Positive_regulation of REN 1 13 0.69 7.05 1.9
146 INT26364 Positive_regulation of CS 1 12 0.30 4.99 1.89
147 INT57063 Negative_regulation of HTR7 1 6 0.57 1.21 1.76
148 INT94892 Regulation of NOSTRIN 1 7 0.31 2.99 1.72
149 INT36121 Regulation of CLPP 1 4 0.59 0.78 1.39
150 INT55899 Positive_regulation of Ptafr 1 6 0.63 4.7 1.34
151 INT32704 Negative_regulation of PGC 5 11 0.54 5.75 1.23
152 INT81368 Binding of Ntf3 2 5 0.34 2.09 1.23
153 INT64466 Transcription of Reg3b 10 1 0.53 11.89 1.16
154 INT17813 Positive_regulation of Hdl2 1 11 0.36 12.23 1.04
155 INT64465 Positive_regulation of Reg3b 4 5 0.69 8.36 0.99
156 INT30157 Gene_expression of Htr2b 1 2 0.48 0 0.94
157 INT16636 Positive_regulation of Ltb4r 1 8 0.26 4.48 0.92
158 INT28733 Regulation of EDAR 1 4 0.12 2.11 0.89
159 INT54606 Gene_expression of Mcpt2 1 4 0.55 0.24 0.8
160 INT66961 Regulation of Localization of OXTR 1 3 0.24 0 0.73
161 INT28402 Negative_regulation of Negative_regulation of MME 1 3 0.43 1.51 0.57
162 INT10862 Positive_regulation of Vldlr 1 4 0.15 2.96 0.49
163 INT97846 Regulation of VEGFC 1 3 0.14 1.2 0.44
164 INT64460 Regulation of Reg3b 4 1 0.60 4.91 0.43
165 INT55898 Localization of C4a 1 2 0.40 1.29 0.41
166 INT513 Transcription of Adrb2 1 2 0.06 0.55 0.37
167 INT52071 Negative_regulation of Negative_regulation of ELANE 1 2 0.13 0.78 0.36
168 INT84143 Negative_regulation of Positive_regulation of Hmox2 1 2 0.03 0.17 0.35
169 INT47995 Positive_regulation of Regulation of NEUROD1 1 1 0.45 0.68 0.34
170 INT25132 Negative_regulation of Gene_expression of Mthfs 1 2 0.08 0.39 0.33
171 INT64459 Transcription of Asap1 2 3 0.52 3.03 0.27
172 INT67962 Protein_catabolism of ATP8A2 1 1 0.64 0.7 0.22
173 INT55900 Negative_regulation of Localization of C4a 1 1 0.22 0.33 0.22
174 INT64467 Regulation of Transcription of Reg3b 2 1 0.23 2.48 0.22
175 INT54607 Gene_expression of Mcpt1 1 2 0.43 0.84 0.21
176 INT132861 Binding of NTF4 2 1 0.10 0.94 0.21
177 INT61040 Positive_regulation of Localization of Ltb4r 1 2 0.03 2.24 0.19
178 INT1770 Positive_regulation of Negative_regulation of Agt 1 2 0.49 1.09 0.17
179 INT64461 Regulation of Gene_expression of Reg3b 1 2 0.61 1.42 0.16
180 INT64463 Positive_regulation of Transcription of Reg3b 1 1 0.46 1.39 0.15
181 INT94893 Regulation of Positive_regulation of NOSTRIN 1 1 0.01 0.51 0.13
182 INT64458 Negative_regulation of Transcription of Reg3b 1 1 0.37 1.43 0.13
183 INT64462 Negative_regulation of Reg3b 1 1 0.37 1.43 0.13
184 INT27344 Localization of Ak1 1 3 0.56 1.84 0.12
185 INT37689 Positive_regulation of HLN2 1 2 0.45 0.82 0.11
186 INT118487 Positive_regulation of Positive_regulation of Xdh 1 1 0.28 0.47 0.11
187 INT84144 Positive_regulation of Positive_regulation of Hmox2 1 1 0.03 0.07 0.11
188 INT94326 Binding of PGC 1 1 0.34 0.65 0.1
189 INT94325 Negative_regulation of Binding of PGC 1 1 0.39 0.65 0.1
190 INT36311 Protein_catabolism of NEUROD1 1 1 0.86 0.51 0.09
191 INT51641 Regulation of Positive_regulation of PTAFR 1 1 0.45 0 0.07
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