J:Fundam Clin Pharmacol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT29837 Gnrh1 Positive_regulation of LH 6 3 0.67 0 3.53
2 INT27788 Gnrh1 Positive_regulation of Positive_regulation of LH 3 1 0.55 0.17 1.72
3 INT21315 AGT Positive_regulation of Npy 1 1 0.03 0.15 0.5
4 INT80116 Binding of C4orf6 and Bdkrb2 1 1 0.41 0.18 0.47
5 INT122237 Gnrh1 Positive_regulation of Gh1 1 2 0.20 0 0.43
6 INT122232 Trh Positive_regulation of Positive_regulation of LH 1 1 0.18 0 0.24
7 INT122225 Trh Positive_regulation of Gh1 1 1 0.06 0 0.24
8 INT122222 Trh Positive_regulation of LH 1 1 0.18 0 0.24
9 INT122236 Gnrh1 Positive_regulation of Trh 1 1 0.29 0 0.19
10 INT122221 Gnrhr Regulation of Gene_expression of LH 1 1 0.03 0 0.12
11 INT122226 Gh1 Regulation of Gene_expression of Pomc 1 1 0.01 0 0.12
12 INT122234 Gh1 Regulation of Gene_expression of Gnrh1 1 1 0.19 0 0.12
13 INT122228 Tshr Regulation of Gene_expression of Gnrh1 1 1 0.20 0 0.12
14 INT122231 Gh1 Regulation of Gene_expression of LH 1 1 0.12 0 0.12
15 INT122235 Fshb Regulation of Gene_expression of LH 1 1 0.14 0 0.12
16 INT122223 Fshb Regulation of Gene_expression of Gnrh1 1 1 0.23 0 0.12
17 INT122239 Tshr Regulation of Gene_expression of LH 1 1 0.13 0 0.12
18 INT122227 Pomc Regulation of Gene_expression of LH 1 1 0.01 0 0.12
19 INT122230 Gnrhr Regulation of Gene_expression of Pomc 1 1 0.00 0 0.12
20 INT122224 Tshr Regulation of Gene_expression of Pomc 1 1 0.01 0 0.12
21 INT122238 Fshb Regulation of Gene_expression of Pomc 1 1 0.01 0 0.12
22 INT122229 Gnrhr Regulation of Gene_expression of Gnrh1 1 1 0.05 0 0.12
23 INT122233 Pomc Regulation of Gene_expression of Gnrh1 1 1 0.01 0 0.12
24 INT146469 Otc Regulation of Cp 1 1 0.10 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
4 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
5 INT5202 Positive_regulation of Gene_expression of Fos 1 1163 0.70 319.28 684
6 INT292 Localization of Penk 1 876 0.81 88.44 669.14
7 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
8 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
9 INT50058 Negative_regulation of Cpox 3 907 0.58 426.28 428.29
10 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
11 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
12 INT287 Localization of Cck 1 518 0.81 86.84 364.04
13 INT876 Localization of Gh1 1 843 0.80 67.75 340.82
14 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
15 INT477 Localization of Avp 1 813 0.81 131.58 300.4
16 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
17 INT2365 Positive_regulation of Cck 2 354 0.70 87.8 277.41
18 INT1893 Localization of Gh 4 1041 0.79 340.23 256.58
19 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
20 INT2085 Positive_regulation of LH 4 441 0.70 60.15 191.02
21 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
22 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
23 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
24 INT880 Positive_regulation of Localization of Gh1 2 304 0.70 14.79 150.23
25 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
26 INT2379 Positive_regulation of Localization of LH 2 349 0.70 27.86 144.53
27 INT3300 Positive_regulation of Gene_expression of Calca 1 179 0.70 77.76 144.2
28 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
29 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
30 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
31 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
32 INT416 Regulation of LH 1 253 0.62 31.48 125.55
33 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
34 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
35 INT874 Positive_regulation of Gh1 5 244 0.70 27.17 97.98
36 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
37 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
38 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
39 INT48767 Negative_regulation of NOS1 2 312 0.59 154.25 90.32
40 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
41 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
42 INT6107 Localization of Npy 4 180 0.81 26.76 81.67
43 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
44 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
45 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
46 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
47 INT1377 Positive_regulation of Trh 1 172 0.70 40.55 69.83
48 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
49 INT1046 Gene_expression of LH 3 180 0.77 29.75 66.87
50 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
51 INT8363 Localization of Nts 1 135 0.81 14.29 61.71
52 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
53 INT546 Binding of ALB 1 311 0.48 85.98 60.14
54 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
55 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
56 INT13938 Positive_regulation of Nkx1-1 1 64 0.68 30.83 58.75
57 INT1782 Regulation of Gh1 2 125 0.62 22 55.74
58 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
59 INT1781 Negative_regulation of Gh1 1 127 0.59 16.94 51.77
60 INT62630 Positive_regulation of CNR1 1 86 0.70 40.34 51.51
61 INT2197 Gene_expression of Gnrh1 2 184 0.78 40.04 50.57
62 INT7093 Negative_regulation of CYP2B6 1 146 0.58 37.3 48.39
63 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
64 INT873 Gene_expression of Gh1 2 130 0.76 26.15 46.75
65 INT5337 Negative_regulation of Npy 1 87 0.59 19.6 46.75
66 INT4776 Localization of TAC1 1 82 0.78 16.89 45.21
67 INT1894 Negative_regulation of Localization of Gh 2 168 0.58 64.12 43.56
68 INT385 Gene_expression of Agt 1 182 0.78 63.62 37.91
69 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
70 INT49 Negative_regulation of Ren 2 129 0.59 37.48 35.62
71 INT946 Negative_regulation of Nts 1 60 0.57 4.61 34.44
72 INT4727 Regulation of TAC1 1 60 0.47 6.74 32.83
73 INT1159 Negative_regulation of Agt 3 133 0.59 40.14 31.67
74 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
75 INT5069 Negative_regulation of Mthfs 1 69 0.57 22.54 31.36
76 INT6765 Localization of Oprl1 1 49 0.81 5.11 28.87
77 INT22211 Positive_regulation of CYP3A4 3 110 0.70 22 28.27
78 INT1613 Binding of Nts 1 58 0.48 10.55 28.18
79 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
80 INT2393 Positive_regulation of Mb 1 174 0.69 93.59 26.79
81 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
82 INT5232 Negative_regulation of Enpep 1 56 0.57 3.25 26.7
83 INT12424 Binding of Npy 1 48 0.48 8.23 24.26
84 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
85 INT7039 Regulation of Nkx1-1 1 22 0.44 10.51 20.89
86 INT53574 Regulation of Tnf 1 45 0.62 40.68 19.71
87 INT55335 Binding of Cpox 2 49 0.34 15.48 18.46
88 INT50403 Negative_regulation of CYP2C19 2 55 0.59 8.97 17.79
89 INT1721 Negative_regulation of HP 1 148 0.42 86.82 16.89
90 INT1261 Localization of Adh1 1 63 0.81 19.36 16.09
91 INT83682 Positive_regulation of Abcb1a 1 22 0.68 3.3 15.6
92 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
93 INT5536 Regulation of NA 1 74 0.59 16.61 15.36
94 INT75918 Negative_regulation of Negative_regulation of Cpox 1 19 0.23 10.05 14.4
95 INT2156 Positive_regulation of Positive_regulation of LH 1 33 0.69 3.18 14.33
96 INT12231 Positive_regulation of Localization of Nts 1 17 0.70 4.54 13.85
97 INT4298 Positive_regulation of Positive_regulation of Gh1 3 30 0.50 1.79 13.32
98 INT3962 Regulation of AGT 1 50 0.62 20.96 13.01
99 INT8086 Negative_regulation of Localization of Npy 1 24 0.59 3.31 12.76
100 INT21632 Positive_regulation of Adh1 1 32 0.70 15.67 11.65
101 INT398 Localization of AGT 1 45 0.78 16.97 11.54
102 INT17826 Positive_regulation of Pla2g1b 1 39 0.70 11.35 10.97
103 INT14124 Negative_regulation of Adra1a 1 34 0.59 7.48 10.85
104 INT10982 Negative_regulation of Agtr1a 1 42 0.58 22.42 10.29
105 INT55418 Regulation of CYP2D6 1 29 0.61 1.83 10.21
106 INT17421 Negative_regulation of Alox5 1 41 0.57 15.23 10.05
107 INT47860 Negative_regulation of Cyp1a2 1 20 0.57 6.06 10
108 INT11238 Positive_regulation of ADA 1 33 0.70 39.7 9.98
109 INT108405 Gene_expression of FAAH 1 48 0.78 28.22 9.97
110 INT475 Negative_regulation of Adra1a 1 28 0.58 7.87 9.83
111 INT11729 Regulation of IGF1 1 71 0.61 44.58 9.71
112 INT68372 Regulation of CYP2C9 1 28 0.62 5.64 9.53
113 INT1218 Negative_regulation of Maob 1 24 0.59 9.76 9.39
114 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
115 INT3755 Positive_regulation of GBE1 1 29 0.40 8.99 8.91
116 INT17701 Gene_expression of PTHLH 1 103 0.78 64.23 8.85
117 INT66819 Binding of CYP2C9 1 41 0.48 8.23 8.76
118 INT386 Positive_regulation of Gene_expression of Agt 1 37 0.70 15.92 8.73
119 INT9573 Regulation of Bdkrb2 1 9 0.43 6.04 8.41
120 INT6625 Negative_regulation of Pth 2 96 0.58 57.6 8.24
121 INT27785 Regulation of HTR2A 1 11 0.44 8 8.18
122 INT1448 Binding of Adra1a 1 23 0.48 1.41 8.01
123 INT14043 Binding of HP 1 52 0.30 26.56 7.76
124 INT1973 Positive_regulation of NAGLU 1 36 0.65 14.78 7
125 INT4438 Negative_regulation of Localization of Adh1 1 18 0.59 6.23 6.95
126 INT63057 Regulation of CYP3A4 1 31 0.61 5.75 6.92
127 INT15775 Positive_regulation of Ren1 1 50 0.69 22.38 6.19
128 INT16568 Positive_regulation of HTR3A 1 14 0.67 4.82 6.01
129 INT4629 Regulation of Fshb 1 12 0.49 1.93 5.95
130 INT5762 Negative_regulation of Gene_expression of Agt 1 18 0.57 6.09 5.84
131 INT30206 Negative_regulation of ADA 4 17 0.59 10.03 5.63
132 INT70907 Negative_regulation of EDNRA 1 30 0.36 19.68 5.49
133 INT13706 Localization of Npr1 1 10 0.59 0.83 5.42
134 INT4598 Negative_regulation of Adh1 1 15 0.54 4.69 5.33
135 INT19993 Negative_regulation of Ren1 1 43 0.58 20.89 5.04
136 INT38087 Regulation of Adh1 1 15 0.61 4.56 4.83
137 INT55419 Regulation of CYP1A2 1 19 0.62 5.3 4.75
138 INT284 Positive_regulation of Ggt6 1 18 0.67 13.56 4.62
139 INT4097 Localization of Pth 1 66 0.81 47.17 4.36
140 INT50581 Regulation of PPIG 2 26 0.55 8.96 4.32
141 INT117205 Transcription of Esr1 1 23 0.65 9.4 4.14
142 INT51180 Regulation of Nkx2-2 1 5 0.26 2.16 4.14
143 INT11605 Regulation of Positive_regulation of Gh 1 10 0.45 2.08 3.85
144 INT9766 Positive_regulation of Ada 1 2 0.47 0.4 3.09
145 INT3812 Negative_regulation of Avpr1a 1 8 0.59 1.42 2.8
146 INT59245 Localization of Pla2g1b 1 10 0.75 4.72 2.76
147 INT108403 Protein_catabolism of FAAH 1 9 0.89 2.5 2.75
148 INT21313 Negative_regulation of Binding of Npy 1 5 0.42 0.39 2.49
149 INT72743 Positive_regulation of Negative_regulation of Ca2 1 4 0.49 1.41 2.11
150 INT28188 Regulation of CYP2E1 1 11 0.62 0.48 2.03
151 INT43944 Negative_regulation of Positive_regulation of Agt 1 4 0.42 1.44 1.93
152 INT71807 Negative_regulation of Cp 1 18 0.58 8.9 1.88
153 INT65611 Regulation of OR3A1 2 3 0.03 0.74 1.77
154 INT16782 Binding of ERLEC1 1 15 0.10 8.23 1.7
155 INT5068 Binding of Mthfs 1 4 0.44 1.26 1.7
156 INT4800 Negative_regulation of Negative_regulation of Nts 1 6 0.43 0.08 1.65
157 INT14954 Gene_expression of COLQ 2 7 0.52 2.59 1.39
158 INT108402 Negative_regulation of Gene_expression of FAAH 1 6 0.43 5.99 1.39
159 INT87181 Gene_expression of Abo 1 4 0.57 2.81 1.19
160 INT72558 Regulation of CYP2C19 1 6 0.54 1.97 1.14
161 INT74297 Gene_expression of Nt5e 1 3 0.75 0.4 1.14
162 INT123825 Localization of C10orf10 2 1 0.00 0 1.13
163 INT27680 Negative_regulation of Ggt6 1 6 0.57 3.4 1.1
164 INT65610 Negative_regulation of OR3A1 1 2 0.05 0.64 0.97
165 INT76147 Gene_expression of OXA1L 1 24 0.52 1.11 0.5
166 INT36770 Positive_regulation of Localization of Pth 1 14 0.70 10.42 0.46
167 INT108404 Negative_regulation of Protein_catabolism of FAAH 1 1 0.33 0.25 0.41
168 INT30918 Positive_regulation of Hexb 1 3 0.45 0.72 0.38
169 INT92084 Negative_regulation of HPFH 1 2 0.42 0.75 0.38
170 INT77022 Localization of Ugt1a7c 3 4 0.41 0.22 0.34
171 INT93754 Negative_regulation of Positive_regulation of Ggt6 1 1 0.57 0.22 0.29
172 INT77024 Negative_regulation of Ugt1a7c 4 1 0.30 0.26 0.26
173 INT65613 Negative_regulation of TEAD2 2 1 0.01 0 0.24
174 INT47121 Regulation of Tshr 1 2 0.12 0.1 0.21
175 INT74298 Positive_regulation of Gene_expression of Nt5e 1 2 0.49 0.24 0.18
176 INT65612 Negative_regulation of Regulation of OR3A1 1 1 0.05 0 0.13
177 INT65609 Negative_regulation of Negative_regulation of TEAD2 1 1 0.01 0 0.12
178 INT77021 Negative_regulation of Localization of Ugt1a7c 2 1 0.22 0.07 0.07
179 INT77023 Localization of Gypc 1 1 0.49 0.06 0.06
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