J:Int. J. Cancer

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 2 0.49 1.18 1.27
2 INT141965 Binding of ADM and CALCRL 5 4 0.33 3.6 0.89
3 INT141963 Binding of CALCRL and RAMP1 2 1 0.43 0.81 0.78
4 INT141964 Binding of ADM and RAMP1 1 4 0.30 2.63 0.47
5 INT95660 MEFV Negative_regulation of UBXN11 1 1 0.36 0.52 0.41
6 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 1 0.16 0.6 0.28
7 INT141966 Binding of CALCRL and RAMP1 Positive_regulation of ADM 1 2 0.40 1.32 0.23
8 INT116467 Vegfa Positive_regulation of Akt1 1 1 0.33 1.41 0.21
9 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 1 0.41 0.56 0.21
10 INT116469 VEGFA Positive_regulation of Amfr 1 1 0.01 1.39 0.21
11 INT116468 VEGFA Positive_regulation of Akt1 1 1 0.04 1.39 0.21
12 INT116466 Vegfa Positive_regulation of Amfr 1 1 0.07 1.41 0.21
13 INT96417 CYC1 Positive_regulation of Casp9 1 1 0.02 0.96 0.17
14 INT96416 CYC1 Positive_regulation of Casp3 1 1 0.02 0.96 0.17
15 INT85274 SGCG Positive_regulation of Mmp2 1 1 0.09 0.46 0.16
16 INT122480 Binding of SERPINE1 and PLAU 4 1 0.40 2.75 0.06
17 INT80013 BTC Positive_regulation of ERBB4 1 1 0.31 0.26 0
18 INT119045 HIF1A Regulation of Regulation of TP53 1 1 0.09 1.06 0
19 INT119046 HIF1A Regulation of TP53 1 1 0.05 1.06 0
20 INT119044 HIF1A Regulation of TCEAL1 1 1 0.02 1.06 0
21 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 1 0.08 1.06 0
22 INT122482 Negative_regulation of CASP3 Negative_regulation of Positive_regulation of CASP8 1 1 0.14 1.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 1 907 0.58 426.28 428.29
2 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
3 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
4 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
5 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
6 INT22548 Positive_regulation of Casp3 2 483 0.70 258.78 213.07
7 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
8 INT50670 Gene_expression of CPOX 3 763 0.76 442.13 195.02
9 INT49441 Negative_regulation of Cpox 3 494 0.59 303.22 177.46
10 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
11 INT50674 Gene_expression of PTGS2 3 459 0.78 253.33 118.51
12 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
13 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
14 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
15 INT71789 Positive_regulation of MAPK1 8 396 0.70 234.44 89.27
16 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
17 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
18 INT50672 Positive_regulation of CPOX 2 205 0.44 125.93 60.06
19 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
20 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
21 INT80124 Negative_regulation of VEGFA 3 450 0.58 311.19 44.53
22 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
23 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
24 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
25 INT77307 Gene_expression of Bcl2 1 399 0.77 319.77 38
26 INT50673 Positive_regulation of Gene_expression of CPOX 1 156 0.54 97.31 37.03
27 INT80690 Positive_regulation of MAPK8 4 223 0.68 125.63 36.75
28 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
29 INT67613 Positive_regulation of PPARG 1 94 0.70 69.15 34.38
30 INT48924 Positive_regulation of Mapk3 1 107 0.67 50.53 34.05
31 INT64171 Regulation of CPOX 1 109 0.36 55.36 32.96
32 INT9655 Regulation of Il6 1 98 0.62 70.92 31.95
33 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
34 INT2671 Positive_regulation of Odc1 1 82 0.70 11.03 29
35 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
36 INT28361 Gene_expression of TP53 5 443 0.78 384.86 28.8
37 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
38 INT8097 Gene_expression of EGF 4 122 0.77 75.94 28.47
39 INT21687 Positive_regulation of ras 3 143 0.58 97.34 27.31
40 INT4877 Gene_expression of MME 24 184 0.78 122.82 24.78
41 INT141612 Gene_expression of Ccr1 1 92 0.77 72.09 24.14
42 INT71781 Phosphorylation of MAPK3 1 62 0.80 27.73 23.73
43 INT83797 Gene_expression of Bcl2l1 8 124 0.77 94.55 22.39
44 INT73625 Gene_expression of PPARG 2 108 0.78 104.85 21.42
45 INT11157 Binding of EGF 1 88 0.48 53.73 21.25
46 INT17848 Binding of PTGS2 1 70 0.46 32.1 20.6
47 INT89396 Phosphorylation of AKT1 1 225 0.82 111.66 19.61
48 INT11803 Positive_regulation of Il2 1 62 0.70 31.44 18.93
49 INT56749 Gene_expression of PCNA 4 219 0.77 111.25 18.42
50 INT9656 Regulation of Gene_expression of Il6 1 57 0.62 33.3 17.71
51 INT95767 Negative_regulation of Mmp9 1 72 0.57 49.14 17.1
52 INT59365 Gene_expression of HTR1A 2 41 0.75 16.31 16.57
53 INT75531 Regulation of MAPK1 1 70 0.61 34.39 15.42
54 INT42810 Gene_expression of CALCRL 3 53 0.77 10.87 15.42
55 INT116465 Gene_expression of Birc5 1 241 0.78 192.31 15.32
56 INT105387 Gene_expression of HIF1A 7 116 0.77 98.62 14.66
57 INT60197 Gene_expression of JUN 2 90 0.78 42.32 14.61
58 INT109511 Gene_expression of Bax 5 133 0.78 113.22 14.36
59 INT69743 Gene_expression of Hmox2 1 36 0.78 20.77 14.26
60 INT80688 Positive_regulation of Positive_regulation of MAPK1 5 72 0.69 39.35 14.11
61 INT50671 Regulation of Gene_expression of CPOX 2 45 0.54 30.99 13.83
62 INT109304 Positive_regulation of Phosphorylation of Akt1 1 113 0.69 40.92 13.49
63 INT18720 Localization of Csf2 1 72 0.67 13.65 13.41
64 INT80222 Negative_regulation of Bcl2 1 82 0.58 69.16 13.18
65 INT20376 Gene_expression of Ccl3 1 39 0.75 45.42 13.15
66 INT51028 Regulation of Il1b 1 28 0.60 21.15 12.47
67 INT75525 Negative_regulation of Positive_regulation of MAPK1 1 40 0.59 25.15 11.15
68 INT102448 Gene_expression of RAMP1 2 23 0.75 4.62 10.9
69 INT85015 Gene_expression of ADM 7 29 0.73 30.75 10.21
70 INT98130 Positive_regulation of CASP8 2 79 0.67 65.29 10.08
71 INT48078 Regulation of Gene_expression of Il1b 1 15 0.62 14.78 9.53
72 INT37896 Positive_regulation of Gene_expression of PTGS1 1 37 0.67 17.28 9.27
73 INT113845 Protein_catabolism of PARP1 1 54 0.88 43.86 8.77
74 INT144430 Gene_expression of Erbb2 4 137 0.77 103.87 8.66
75 INT13435 Positive_regulation of RTCA 1 31 0.60 7.19 8.5
76 INT78696 Regulation of Positive_regulation of Casp3 1 9 0.39 2.93 8.2
77 INT88919 Positive_regulation of Casp9 2 39 0.70 28.64 8.18
78 INT82762 Positive_regulation of Positive_regulation of Mapk3 1 23 0.67 7.72 7.91
79 INT106522 Negative_regulation of Phosphorylation of Akt1 1 65 0.58 34.44 7.83
80 INT77306 Negative_regulation of Gene_expression of Bcl2 1 46 0.58 38.05 7.71
81 INT80686 Positive_regulation of Positive_regulation of MAPK8 2 42 0.68 26.95 7.63
82 INT113705 Gene_expression of Egfr 1 228 0.78 149.05 7.59
83 INT91509 Localization of CYC1 1 39 0.78 34.74 7.17
84 INT102814 Negative_regulation of CASP3 2 46 0.43 28.54 6.94
85 INT102749 Positive_regulation of Positive_regulation of CASP3 1 32 0.67 26.07 6.93
86 INT61114 Gene_expression of Ppard 1 23 0.75 14.98 6.62
87 INT68653 Negative_regulation of JUN 3 34 0.58 14.27 6.56
88 INT60692 Gene_expression of Pglyrp1 1 15 0.10 8.47 6.51
89 INT67890 Positive_regulation of Gene_expression of SGCG 1 26 0.67 9.91 6.41
90 INT66227 Gene_expression of COX18 3 41 0.50 26.91 6.26
91 INT94197 Negative_regulation of Phosphorylation of MAPK3 1 13 0.57 5.51 6.18
92 INT3819 Positive_regulation of Apc 2 36 0.69 27.03 6.02
93 INT335 Binding of Adra1a 1 16 0.36 6.16 6
94 INT103918 Phosphorylation of Tyr 1 12 0.47 10.12 5.96
95 INT75501 Gene_expression of CCND1 1 90 0.76 60.86 5.93
96 INT104330 Negative_regulation of CDKN1A 5 57 0.58 39.93 5.88
97 INT111545 Phosphorylation of VEGFA 1 50 0.76 22.19 5.88
98 INT100078 Positive_regulation of Positive_regulation of PPARG 1 11 0.70 3.6 5.86
99 INT87470 Gene_expression of SDC1 9 27 0.78 24.86 5.81
100 INT49440 Localization of Cpox 1 27 0.53 11.26 5.79
101 INT6601 Gene_expression of PPAP2A 1 21 0.27 3.13 5.52
102 INT64176 Transcription of CPOX 1 35 0.41 15.1 5.5
103 INT21609 Positive_regulation of RASGRP1 1 58 0.50 40.78 5.47
104 INT95120 Positive_regulation of CASP9 1 76 0.67 67.55 5.33
105 INT87022 Gene_expression of Apc 2 68 0.67 46.98 5.22
106 INT60585 Regulation of TP53 1 59 0.59 54.55 5.21
107 INT92330 Gene_expression of WDTC1 1 22 0.47 13.12 5.15
108 INT34358 Binding of MME 1 13 0.37 7.25 5.14
109 INT109513 Positive_regulation of Gene_expression of Bax 1 37 0.67 29.52 5.06
110 INT116464 Negative_regulation of Birc5 1 53 0.59 45.4 4.91
111 INT105393 Positive_regulation of Localization of VEGFA 1 66 0.70 45.45 4.9
112 INT20676 Gene_expression of Ctse 9 16 0.77 10.59 4.68
113 INT62684 Negative_regulation of TP53 2 66 0.58 66.09 4.62
114 INT97264 Binding of Mc1r 1 9 0.36 4.27 4.53
115 INT57749 Negative_regulation of Gene_expression of TP53 2 39 0.56 36.79 4.45
116 INT73626 Positive_regulation of Gene_expression of PPARG 3 22 0.70 18.82 4.4
117 INT85126 Negative_regulation of MAP2K6 1 19 0.39 12.12 4.39
118 INT99905 Negative_regulation of Negative_regulation of Cpox 1 11 0.35 7.01 4.37
119 INT103914 Phosphorylation of Egfr 1 35 0.82 16.98 4.31
120 INT75523 Regulation of MAPK8 1 21 0.33 11.18 4.28
121 INT144428 Positive_regulation of Gene_expression of Erbb2 4 41 0.69 41.4 4.13
122 INT100372 Gene_expression of Flt1 1 47 0.71 24.33 4.09
123 INT88414 Negative_regulation of CDK2 2 30 0.57 18.4 3.96
124 INT99509 Gene_expression of CFLAR 2 25 0.75 22.59 3.78
125 INT102452 Gene_expression of RAMP2 2 6 0.69 7.11 3.77
126 INT88805 Protein_catabolism of CASP3 1 24 0.86 18.38 3.7
127 INT31758 Positive_regulation of Egf 1 32 0.66 19.42 3.64
128 INT64766 Gene_expression of TWIST1 8 41 0.76 37.89 3.4
129 INT139807 Gene_expression of Braf 1 7 0.51 8.78 3.34
130 INT92335 Gene_expression of TBK1 1 11 0.28 8.98 3
131 INT14872 Gene_expression of TGFB3 2 15 0.55 12.45 2.96
132 INT91432 Binding of MMRN1 1 23 0.36 9.79 2.95
133 INT31757 Negative_regulation of Egf 1 18 0.41 9.7 2.94
134 INT19335 Positive_regulation of CYC1 1 11 0.67 9.82 2.92
135 INT105390 Positive_regulation of Gene_expression of HIF1A 1 27 0.49 26.3 2.88
136 INT89401 Negative_regulation of Phosphorylation of AKT1 1 68 0.58 35.61 2.8
137 INT116463 Negative_regulation of Gene_expression of Birc5 1 40 0.59 33.99 2.74
138 INT90875 Negative_regulation of CCND1 1 31 0.42 26.22 2.66
139 INT16463 Gene_expression of FTH1 2 15 0.65 6.28 2.66
140 INT4879 Positive_regulation of Gene_expression of MME 3 17 0.69 12.48 2.46
141 INT102646 Positive_regulation of MAP2K6 1 3 0.63 4.37 2.44
142 INT22679 Binding of SERPINE1 1 25 0.36 17.33 2.36
143 INT50558 Negative_regulation of PCNA 1 31 0.57 13.97 2.3
144 INT116880 Gene_expression of SYCP1 8 6 0.73 13.37 2.29
145 INT101572 Negative_regulation of Gene_expression of PCNA 1 24 0.53 13.87 2.21
146 INT103917 Positive_regulation of Phosphorylation of Egfr 1 12 0.68 7.23 2.18
147 INT116194 Gene_expression of Casp8 1 14 0.75 14.61 2.13
148 INT66226 Positive_regulation of Gene_expression of COX18 3 10 0.31 4.41 2.11
149 INT2844 Positive_regulation of ID1 2 6 0.70 3.92 2.03
150 INT141968 Positive_regulation of ADM 5 12 0.65 11.19 2
151 INT48880 Positive_regulation of TWIST1 1 15 0.59 8.6 1.98
152 INT13803 Gene_expression of Panc2 3 8 0.07 10.41 1.98
153 INT112698 Gene_expression of Bid 1 8 0.64 6.52 1.97
154 INT57618 Binding of GTPBP4 1 9 0.43 1.61 1.87
155 INT120563 Positive_regulation of Gene_expression of Egfr 1 56 0.70 46.19 1.82
156 INT110579 Negative_regulation of Gene_expression of MME 1 15 0.58 12.8 1.81
157 INT122488 Protein_catabolism of CASP9 1 8 0.46 8.64 1.8
158 INT122487 Positive_regulation of Positive_regulation of CASP9 1 16 0.67 17.88 1.79
159 INT102449 Binding of ADM 1 12 0.33 5.85 1.73
160 INT6598 Gene_expression of ITGA2 3 9 0.46 4.88 1.72
161 INT60693 Positive_regulation of Gene_expression of Pglyrp1 2 4 0.02 2.73 1.72
162 INT141967 Gene_expression of RAMP3 2 4 0.69 3.35 1.69
163 INT21788 Positive_regulation of ERBB2 2 49 0.66 28.88 1.68
164 INT72676 Gene_expression of APOA1 1 34 0.75 34.15 1.67
165 INT96214 Gene_expression of TCEAL1 5 19 0.63 16.99 1.66
166 INT88412 Positive_regulation of CDK2 1 17 0.57 8.49 1.66
167 INT79691 Regulation of Gene_expression of PPARG 1 10 0.50 10.44 1.62
168 INT95056 Positive_regulation of Gene_expression of Ppard 1 5 0.52 3.84 1.6
169 INT77586 Positive_regulation of Gene_expression of HTR1A 2 6 0.46 3.54 1.51
170 INT119048 Negative_regulation of Gene_expression of HIF1A 2 10 0.57 9.23 1.5
171 INT52962 Binding of ERBB2 2 77 0.47 50.03 1.49
172 INT650 Gene_expression of Afp 3 13 0.78 7.44 1.47
173 INT107985 Gene_expression of MLH1 1 29 0.67 31.31 1.46
174 INT46736 Negative_regulation of Odc1 1 10 0.51 7.6 1.39
175 INT100373 Negative_regulation of Gene_expression of Flt1 1 11 0.53 10 1.37
176 INT41805 Localization of Neu3 1 4 0.10 0.33 1.28
177 INT92331 Gene_expression of ATP8A2 1 6 0.75 2.99 1.21
178 INT72675 Positive_regulation of SI 1 3 0.69 2.27 1.21
179 INT141969 Positive_regulation of Gene_expression of ADM 1 4 0.57 4.07 1.2
180 INT122481 Binding of PLAU 1 10 0.36 6.1 1.16
181 INT6599 Binding of ITGA2 2 4 0.35 3.6 1.16
182 INT128987 Negative_regulation of Ccnd1 1 24 0.52 15.78 1.15
183 INT122485 Negative_regulation of CASP9 3 18 0.46 15.78 1.12
184 INT34629 Gene_expression of PVR 2 3 0.24 1.58 1.12
185 INT103919 Negative_regulation of Phosphorylation of Tyr 1 2 0.32 2.01 1.12
186 INT128467 Gene_expression of Fxyd3 6 1 0.78 5.65 1.11
187 INT144427 Transcription of Ccnd1 1 10 0.41 7.89 1.07
188 INT92326 Gene_expression of Lamp1 2 3 0.13 0.93 0.99
189 INT116883 Gene_expression of SSX1 3 3 0.58 5.83 0.98
190 INT141475 Negative_regulation of Gene_expression of TWIST1 1 5 0.41 3.94 0.97
191 INT102645 Negative_regulation of Gene_expression of COX18 1 3 0.12 2.81 0.92
192 INT116197 Positive_regulation of Gene_expression of CFLAR 2 6 0.67 7.11 0.9
193 INT34923 Positive_regulation of MTHFS 1 2 0.49 1.4 0.9
194 INT72672 Positive_regulation of Gene_expression of APOA1 1 4 0.67 3.81 0.89
195 INT109007 Positive_regulation of Ccnd1 2 23 0.53 9.5 0.86
196 INT113841 Gene_expression of CCNB1 1 11 0.75 3.46 0.86
197 INT52062 Negative_regulation of PDK1 1 3 0.37 1.59 0.86
198 INT90363 Regulation of SDC1 2 3 0.45 3.68 0.83
199 INT90364 Positive_regulation of Gene_expression of SDC1 2 3 0.70 2.59 0.83
200 INT6602 Gene_expression of RPS6KA6 2 3 0.56 1.75 0.82
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