J:The Open Rheumatology Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT131156 Binding of RUNX1 and TNF 2 1 0.03 3.44 1.42
2 INT303857 DDR1 Positive_regulation of IL8 1 1 0.05 1.5 0.42
3 INT303858 DDR1 Positive_regulation of CXCR2 1 1 0.11 1.5 0.42
4 INT252033 Binding of HLA-DQA2 and KLRD1 1 1 0.00 0.54 0.29
5 INT252032 Binding of Calm1 and DXIum1 1 5 0.02 0.48 0.13
6 INT252020 Binding of HLA-A and ELOVL1 1 1 0.01 1.41 0
7 INT252031 DXIum1 Positive_regulation of Calm1 1 1 0.02 0 0
8 INT297347 Binding of MEFV and SAA@ 1 1 0.03 1.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
5 INT9158 Gene_expression of Tnf 2 722 0.78 522.01 277.68
6 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 3 1050 0.78 698.72 270
8 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
9 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
10 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
11 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
12 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
13 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
14 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
15 INT69440 Gene_expression of ROS1 7 752 0.78 477.64 103.83
16 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
17 INT68682 Positive_regulation of VEGFA 4 640 0.70 454.14 81.65
18 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
19 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
20 INT79494 Positive_regulation of Gene_expression of VEGFA 2 577 0.70 442.94 69.73
21 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
22 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
23 INT4509 Gene_expression of IGG 2 426 0.76 293.69 56.64
24 INT251 Regulation of INS 1 398 0.62 232.47 55.04
25 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
26 INT80124 Negative_regulation of VEGFA 2 450 0.58 311.19 44.53
27 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
28 INT4004 Gene_expression of IGHG3 2 321 0.71 221.03 42.33
29 INT69437 Positive_regulation of ROS1 4 328 0.58 222.83 40.56
30 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
31 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
32 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
33 INT101992 Localization of VEGFA 2 413 0.81 258.23 36.15
34 INT74563 Positive_regulation of Gene_expression of ROS1 2 258 0.61 168.18 34.08
35 INT10248 Gene_expression of KRT20 2 436 0.78 231.96 32.88
36 INT99688 Negative_regulation of Gene_expression of VEGFA 2 274 0.58 201.8 31.1
37 INT28361 Gene_expression of TP53 2 443 0.78 384.86 28.8
38 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
39 INT823 Negative_regulation of ESR1 1 144 0.58 63.72 22.52
40 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
41 INT28215 Gene_expression of CDKN1A 2 196 0.76 113.9 18.3
42 INT28642 Gene_expression of CXCR2 1 60 0.78 38.69 18.11
43 INT65856 Positive_regulation of TP53 2 138 0.67 112.65 16.71
44 INT10834 Binding of IL8 2 65 0.48 41.66 16.53
45 INT81486 Localization of MMP3 1 31 0.81 12.94 15.21
46 INT103210 Localization of MMP1 1 43 0.78 12.15 15.13
47 INT34590 Gene_expression of ALPP 1 199 0.75 89.85 15.1
48 INT75502 Positive_regulation of CDKN1A 1 123 0.68 70.75 14.74
49 INT88544 Gene_expression of MMRN1 2 102 0.75 68.8 14.55
50 INT10173 Binding of Tnf 2 45 0.48 35.6 14.32
51 INT72127 Protein_catabolism of MMRN1 3 68 0.52 56 14.13
52 INT78472 Gene_expression of CDKN2A 1 223 0.78 173.76 13.61
53 INT1125 Positive_regulation of IGHG3 1 130 0.69 112.07 13.18
54 INT55687 Localization of TIMP1 2 47 0.74 30.24 12.31
55 INT79545 Positive_regulation of Gene_expression of ESR1 1 82 0.64 39.42 12.18
56 INT112003 Localization of ROS1 1 94 0.73 66.32 12.16
57 INT111335 Gene_expression of HSPD1 2 57 0.75 55.51 10.38
58 INT94784 Binding of ROS1 1 113 0.40 71.57 10.26
59 INT56985 Gene_expression of MEFV 2 56 0.71 46.71 9.47
60 INT137400 Regulation of Mtx1 1 16 0.52 9.19 9.45
61 INT27551 Gene_expression of SERPINH1 1 45 0.62 42.87 9.04
62 INT725 Negative_regulation of IgG 3 62 0.41 37.21 8.16
63 INT8799 Negative_regulation of Csrp1 1 24 0.58 11.01 6.86
64 INT69441 Regulation of Gene_expression of ROS1 1 38 0.50 26.78 6.78
65 INT89794 Positive_regulation of CDKN2A 2 58 0.67 50.18 5.38
66 INT66423 Binding of ELOVL1 1 52 0.40 61.63 5.16
67 INT62958 Positive_regulation of CXCR2 1 14 0.59 8.61 4.92
68 INT160055 Localization of CDKN1A 2 15 0.78 12.56 4.83
69 INT29326 Gene_expression of Calm1 7 17 0.67 3.71 4.53
70 INT88545 Localization of MMRN1 1 21 0.78 16.67 4.01
71 INT207426 Gene_expression of COL10A1 1 27 0.65 12.02 3.85
72 INT49191 Gene_expression of IFNAR1 1 14 0.41 9.96 3.84
73 INT173849 Positive_regulation of Localization of MMP3 1 7 0.49 4.6 3.65
74 INT47949 Positive_regulation of ELOVL1 4 19 0.42 29.78 3.3
75 INT55690 Positive_regulation of Localization of TIMP1 1 8 0.50 4.77 3.28
76 INT117080 Localization of Csrp1 1 6 0.42 7.23 3.09
77 INT129358 Gene_expression of ELOVL1 5 23 0.66 29.39 2.83
78 INT38673 Negative_regulation of KRT20 1 38 0.42 22.49 2.77
79 INT185407 Binding of PER1 1 13 0.42 9.32 2.6
80 INT192337 Positive_regulation of DDR1 3 11 0.41 10.34 2.38
81 INT19646 Binding of KLRD1 1 9 0.04 4.27 2.35
82 INT177998 Binding of RUNX1 1 7 0.35 7.12 2.08
83 INT68243 Regulation of Gene_expression of IgG 1 10 0.44 4.93 2.04
84 INT19609 Positive_regulation of PSIP1 1 4 0.49 4.54 2.04
85 INT220211 Gene_expression of RUNX2 1 7 0.71 7.31 2
86 INT125080 Positive_regulation of Positive_regulation of TP53 1 21 0.58 16.16 1.98
87 INT111143 Regulation of Gene_expression of KRT20 2 22 0.26 5.65 1.93
88 INT174653 Localization of MEFV 2 15 0.70 12.06 1.93
89 INT65855 Localization of TP53 2 18 0.76 17.08 1.89
90 INT192684 Negative_regulation of vs 1 15 0.19 9.18 1.75
91 INT183147 Positive_regulation of Gene_expression of MEFV 2 6 0.50 4.67 1.73
92 INT89116 Regulation of Positive_regulation of VEGFA 1 8 0.43 6.62 1.5
93 INT47950 Negative_regulation of ELOVL1 1 15 0.41 20.33 1.41
94 INT64952 Binding of HLA-DQA2 2 11 0.10 7.23 1.39
95 INT61076 Gene_expression of RHD 1 9 0.65 3.52 1.39
96 INT175636 Positive_regulation of Protein_catabolism of MMRN1 1 8 0.30 11.38 1.39
97 INT153297 Regulation of MEFV 3 6 0.40 11.09 0.71
98 INT183144 Positive_regulation of Localization of MEFV 1 2 0.42 2.61 0.51
99 INT220088 Positive_regulation of Positive_regulation of CDKN2A 1 4 0.49 4.04 0.44
100 INT252024 Regulation of DXIum1 3 1 0.03 1.39 0.38
101 INT252022 Phosphorylation of Calm1 3 1 0.55 0.55 0.27
102 INT252023 Positive_regulation of Calm1 2 1 0.44 0.79 0.27
103 INT184624 Localization of CDKN2A 1 8 0.74 7.87 0.25
104 INT188352 Regulation of Calm1 1 2 0.39 1.6 0.21
105 INT252026 Localization of Calm1 3 1 0.65 0.55 0.15
106 INT252021 Binding of Calm1 4 1 0.42 0.69 0.13
107 INT252028 Binding of DXIum1 3 1 0.02 0.48 0.13
108 INT252029 Positive_regulation of DXIum1 3 1 0.03 0.06 0.06
109 INT252025 Gene_expression of DXIum1 1 1 0.03 0 0
110 INT252027 Localization of DXIum1 1 1 0.04 0 0
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