P:HCN1

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pChart

Pain Term
Category Molecule
Synonyms Brain Cyclic Nucleotide Gated Channel 1, Brain Cyclic Nucleotide-gated Channel 1 Potassium/sodium Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1, Hyperpolarization Activated Cyclic Nucleotide-gated Potassium Channel 1
Pain Specific No
Documents 26
Hot Single Events 54
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for HCN1. They are ordered first by their pain relevance and then by number of times they were reported for HCN1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68 68.28
2 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
3 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
4 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
5 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
6 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
7 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
8 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
9 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
10 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
11 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
12 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
13 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for HCN1. They are ordered first by their pain relevance and then by number of times they were reported in HCN1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT108690 Gene_expression of Hcn1 19 0.76 7.2 8 100.00
2 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 100.00
3 INT148715 Gene_expression of HCN1 4 0.78 1.29 1.98 100.00
4 INT117212 Gene_expression of Hcn2 13 0.78 5.83 8.19 100.00
5 INT163497 Gene_expression of Hcn3 5 0.76 8.4 4.33 100.00
6 INT33667 Gene_expression of Cnga1 15 0.72 10.09 10.4 100.00
7 INT148714 Regulation of HCN1 2 0.45 0.53 1.02 100.00
8 INT245895 Localization of Hcn1 1 0.74 0.47 0.98 100.00
9 INT148710 Negative_regulation of HCN1 3 0.43 0 1.09 100.00
10 INT99049 Positive_regulation of Hcn1 5 0.43 0.68 2.75 100.00
11 INT51547 Positive_regulation of HCN1 3 0.50 0.23 1.13 100.00
12 INT148713 Positive_regulation of HCN4 1 0.50 0 0.96 100.00
13 INT245897 Transcription of Hcn1 1 0.49 0.07 0.64 100.00
14 INT159769 Positive_regulation of Gene_expression of Hcn1 2 0.64 2.66 2.83 100.00
15 INT159770 Positive_regulation of Gene_expression of Hcn2 2 0.67 2.65 2.82 100.00
16 INT99050 Regulation of Hcn1 2 0.42 0.66 1.33 100.00
17 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12 100.00
18 INT163498 Positive_regulation of Gene_expression of Hcn3 1 0.68 2.04 1.5 100.00
19 INT285171 Localization of HCN1 1 0.60 0 0.15 100.00
20 INT245893 Negative_regulation of Gene_expression of Hcn1 1 0.40 0.35 0.17 100.00
21 INT117213 Gene_expression of Cnga4 4 0.50 1.05 2.13 100.00
22 INT130985 Negative_regulation of Positive_regulation of Hcn1 1 0.15 0 0.41 100.00
23 INT130986 Positive_regulation of Positive_regulation of Hcn1 1 0.16 0 0.41 100.00
24 INT138640 Transcription of Hcn2 2 0.66 0.51 1.05 99.96
25 INT148711 Regulation of HCN4 1 0.45 0 0.5 99.90
26 INT148712 Gene_expression of HCN4 1 0.77 0 0.34 99.90
27 INT159772 Regulation of Hcn2 1 0.26 0.53 0.71 99.90
28 INT95492 Gene_expression of Nefh 20 0.67 12.68 10.46 99.80
29 INT245894 Transcription of Hcn3 1 0.40 0 0.41 99.76
30 INT117211 Positive_regulation of Cnga4 1 0.32 0.07 0.28 99.56
31 INT94030 Binding of Nefh 3 0.48 1.93 1.57 99.02
32 INT245898 Negative_regulation of Hcn4 2 0.40 1.84 0.49 98.76
33 INT207667 Binding of Hcn4 2 0.35 0 0.28 96.20
34 INT245900 Regulation of Binding of Hcn4 1 0.36 0 0.22 96.20
35 INT144790 Negative_regulation of Negative_regulation of Hcn2 1 0.53 0.06 0.4 96.20
36 INT285173 Binding of HCN1 1 0.26 0 0.09 95.92
37 INT245899 Negative_regulation of Gene_expression of Hcn3 1 0.44 1.89 0.45 95.76
38 INT144789 Negative_regulation of Hcn2 2 0.53 0.24 0.8 95.60
39 INT140710 Regulation of Gene_expression of Cnga1 2 0.23 0.91 0.92 94.64
40 INT136672 Positive_regulation of Cnga1 11 0.58 4.46 4.61 94.40
41 INT285168 Gene_expression of MALAT1 1 0.11 0 0.12 94.16
42 INT159771 Positive_regulation of Gene_expression of Cnga1 2 0.49 2.66 2.79 92.84
43 INT117215 Positive_regulation of Hcn2 1 0.50 0.15 0.92 92.36
44 INT108689 Negative_regulation of Cnga1 3 0.38 2.39 2.79 90.92
45 INT127407 Gene_expression of Hcn3 1 0.77 0.62 0.32 89.96
46 INT127408 Positive_regulation of Gene_expression of Hcn3 1 0.69 0.35 0.18 89.96
47 INT159139 Positive_regulation of MALAT1 3 0.41 1.73 0.33 89.36
48 INT285175 Binding of MALAT1 1 0.06 0 0.15 89.36
49 INT158954 Regulation of Cnga1 4 0.39 0 1.4 88.80
50 INT127410 Negative_regulation of Hcn3 1 0.42 0.34 0.18 88.56
51 INT285167 Binding of PSMC4 2 0.04 0.56 0.72 88.04
52 INT49060 Negative_regulation of Camk2a 10 0.45 2.59 4.67 86.24
53 INT285165 Binding of MIR377 1 0.00 0 0.58 82.04
54 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 81.76
55 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27 79.76
56 INT157422 Gene_expression of Hcn1 2 0.51 0.29 0.6 79.56
57 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 78.72
58 INT117210 Binding of Hcn2 3 0.48 0.82 1.91 78.52
59 INT174348 Gene_expression of Vmn1r51 6 0.23 0.3 0.22 76.44
60 INT174360 Gene_expression of Vmn1r45 1 0.01 0.28 0.08 76.44
61 INT163499 Regulation of Gene_expression of Hcn4 1 0.23 0.9 0.49 74.40
62 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7 74.20
63 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 73.08
64 INT141774 Negative_regulation of Hcn1 4 0.48 0.77 0.98 71.24
65 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 70.48
66 INT19799 Binding of Ca2 71 0.48 13.69 12.92 70.00
67 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75 69.72
68 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47 69.28
69 INT285174 Gene_expression of MIR377 1 0.01 0 0.12 68.96
70 INT271764 Binding of Cnga1 2 0.27 0.16 0.38 68.96
71 INT127409 Transcription of Hcn3 1 0.71 0.45 0.24 60.20
72 INT132967 Gene_expression of Hcn2 2 0.71 0.09 0.54 58.08
73 INT271765 Regulation of Cav3 1 0.05 0 0.14 56.80
74 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 56.72
75 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39 52.44
76 INT117216 Localization of Hcn2 1 0.75 0.16 0.69 46.84
77 INT174357 Binding of Vmn1r49 1 0.22 0 0.07 46.68
78 INT174356 Binding of Vmn1r51 1 0.10 0 0.07 46.68
79 INT245896 Negative_regulation of Gene_expression of Hcn4 1 0.47 1.35 0.09 46.48
80 INT285166 Positive_regulation of Positive_regulation of MALAT1 1 0.08 0 0.05 41.12
81 INT141037 Positive_regulation of Aifm1 3 0.45 3.32 1.38 40.72
82 INT17561 Localization of Car2 303 0.79 60.95 44.52 36.48
83 INT141036 Negative_regulation of Aifm1 1 0.00 1.26 1.07 31.28
84 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 29.84
85 INT174346 Gene_expression of Vmn1r49 1 0.42 0.27 0.05 29.52
86 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73 27.68
87 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 22.44
88 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 22.44
89 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 22.44
90 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 17.44
91 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 16.48
92 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 16.44
93 INT174384 Binding of TAS2R16 1 0.07 0 0.06 13.52
94 INT174347 Binding of Tas2r105 1 0.09 0 0.06 9.68
95 INT174345 Positive_regulation of Tas2r105 1 0.12 0 0.06 8.56
96 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
97 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
98 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
99 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
100 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
101 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
102 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
103 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
104 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
105 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
106 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
107 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
108 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
109 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
110 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
111 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
112 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
113 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
114 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
115 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
116 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
117 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
118 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
119 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
120 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
121 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22 5.00
122 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
123 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
124 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
125 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
126 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26 5.00
127 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
128 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
129 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
130 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 5.00
131 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
132 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
133 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
134 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
135 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 5.00
136 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 5.00
137 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
138 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
139 INT62629 Localization of CNR1 35 0.76 11.86 16.3 5.00
140 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 5.00
141 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82 5.00
142 INT71150 Binding of NGF 22 0.46 13.67 14.81 5.00
143 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 5.00
144 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 5.00
145 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
146 INT72579 Localization of BDNF 56 0.80 14.84 10.65 5.00
147 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07 5.00
148 INT6356 Binding of Gabbr1 30 0.48 4.62 9.82 5.00
149 INT92755 Regulation of MRGPRX1 26 0.27 3.63 7.37 5.00
150 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 5.00
151 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4 5.00
152 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
153 INT33612 Binding of NTS 16 0.46 4.65 6 5.00
154 INT64270 Gene_expression of GRM2 10 0.75 1.72 5.41 5.00
155 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 5.00
156 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 5.00
157 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64 5.00
158 INT112040 Localization of P2RX2 6 0.73 4.69 4.3 5.00
159 INT77515 Positive_regulation of ASIC3 12 0.67 3.67 4.19 5.00
160 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 5.00
161 INT144051 Positive_regulation of Gene_expression of PTGER1 11 0.12 4.46 3.97 5.00
162 INT152743 Positive_regulation of Localization of BDNF 7 0.56 4.04 3.74 5.00
163 INT158843 Regulation of NALCN 6 0.04 2.89 3.63 5.00
164 INT109851 Negative_regulation of P2RX3 7 0.57 3.55 3.61 5.00
165 INT220078 Positive_regulation of Negative_regulation of KNG1 3 0.13 5.03 3.41 5.00
166 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 5.00
167 INT88745 Gene_expression of GRM3 6 0.75 2.61 2.83 5.00
168 INT123910 Gene_expression of CXCL16 5 0.49 3.81 2.82 5.00
169 INT118887 Positive_regulation of Neu3 3 0.01 8.39 2.62 5.00
170 INT135000 Positive_regulation of Gene_expression of GRM2 1 0.49 1.27 2.62 5.00
171 INT129191 Regulation of ATF3 8 0.61 17.04 2.54 5.00
172 INT95799 Binding of NTRK2 8 0.35 2.95 2.47 5.00
173 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 5.00
174 INT74292 Negative_regulation of GLRA1 2 0.37 1.3 2.34 5.00
175 INT118291 Binding of TXK 19 0.10 11.77 1.94 5.00
176 INT144944 Positive_regulation of Negative_regulation of TRPV1 3 0.46 0.84 1.89 5.00
177 INT50743 Positive_regulation of Trpc2 12 0.44 1.99 1.87 5.00
178 INT104672 Negative_regulation of Neu3 4 0.14 4.67 1.82 5.00
179 INT220079 Phosphorylation of NALCN 1 0.01 1.05 1.48 5.00
180 INT96372 Gene_expression of Gabbr2 4 0.45 0.22 1.42 5.00
181 INT220077 Negative_regulation of Binding of TNFRSF1B 1 0.26 1.1 1.42 5.00
182 INT220073 Negative_regulation of Binding of NGF 1 0.23 1.1 1.39 5.00
183 INT220076 Negative_regulation of Negative_regulation of GLRA1 1 0.00 0.66 1.37 5.00
184 INT220075 Positive_regulation of GRM3 1 0.11 1.36 1.28 5.00
185 INT220080 Gene_expression of SSX3 1 0.01 1.06 1.23 5.00
186 INT118632 Binding of Gabbr2 2 0.32 0.25 1.12 5.00
187 INT129186 Positive_regulation of Regulation of ATF3 3 0.50 3.01 1.02 5.00
188 INT220074 Localization of ATF3 1 0.18 1.17 1.01 5.00
189 INT114761 Gene_expression of Tas1r2 6 0.71 0.93 0.83 5.00
190 INT87838 Gene_expression of Dcn 7 0.75 0.74 0.79 5.00
191 INT214945 Regulation of Neu3 11 0.01 1.65 0.51 5.00
192 INT174359 Gene_expression of Tas1r1 1 0.21 0 0.23 5.00
193 INT173448 Gene_expression of Tas1r3 4 0.53 0.14 0.23 5.00
194 INT137111 Binding of Pbsn 2 0.25 0.29 0.14 5.00
195 INT174349 Regulation of Tas1r1 1 0.03 0 0.1 5.00
196 INT334963 Positive_regulation of Positive_regulation of Cnga1 2 0.26 0 0.08 5.00
197 INT337606 Localization of Cnga1 1 0.42 0 0.04 5.00
198 INT337607 Gene_expression of Guca1a 1 0.07 0 0 5.00
199 INT257475 Positive_regulation of Pir 1 0.47 1.12 0 5.00
200 INT174354 Gene_expression of Avpr2 8 0.35 0.87 0 5.00
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