P:Nav1.3

This page displays the top molecular interactions and top single events that were mentioned in the literature for Nav1.3. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nav1.3. They are ordered first by their pain relevance and then by number of times they were reported for Nav1.3. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT128778	Binding of Mcam and Nav1	1	0.03	0.51	2.28	100.00
2	INT128777	Binding of Cntn1 and Nav1	1	0.48	0.51	2.28	100.00
3	INT112642	Positive_regulation of Kcnma1 Positive_regulation of Nav1	1	0.02	0	0.89	100.00
4	INT119744	Binding of BHLHE22 and NAV1	1	0.29	0.49	1.09	100.00
5	INT120834	Binding of CNTN1 and SCN3A	1	0.01	0.41	0.49	100.00
6	INT119747	NAV1 Regulation of Gene_expression of BHLHE22	1	0.31	0.26	0.53	94.32
7	INT119745	NEUROD1 Regulation of Gene_expression of BHLHE22	1	0.11	0.26	0.53	93.60
8	INT119746	OR51B4 Regulation of Gene_expression of BHLHE22	1	0.08	0.26	0.52	93.04
9	INT309953	Binding of Atrn and Nav1	1	0.00	0.23	0.53	80.64
10	INT128776	Cntn1 Positive_regulation of Gene_expression of Pde6b	1	0.02	0.55	1.26	43.52
11	INT283028	Nav1 Regulation of Ca2	1	0.08	0	0.24	16.88
12	INT283027	Pirt Regulation of Ca2	1	0.00	0	0.24	16.88
13	INT211694	Binding of Cntnap1 and Nav1	1	0.04	0	3.14	5.00
14	INT317184	BMS1 Regulation of Gene_expression of NAV1	1	0.03	1.94	1.62	5.00
15	INT231391	Binding of Lpar1 and Rbm39	1	0.00	1.04	1.04	5.00
16	INT231392	Enpp2 Positive_regulation of Gene_expression of Lpar1	2	0.38	2.19	0.93	5.00
17	INT231390	Pla2g4a Regulation of Pla2g2a	1	0.08	0.92	0.77	5.00
18	INT231388	Pla2g4a Regulation of Pla2g6	1	0.08	0.92	0.77	5.00
19	INT309954	Binding of Pkp2 and Nav1	1	0.29	0.29	0.13	5.00
20	INT312841	Pou3f1 Regulation of Gene_expression of Plp1	1	0.24	0.16	0.09	5.00
21	INT312839	Egr2 Regulation of Gene_expression of Mbp	1	0.32	0.16	0.09	5.00
22	INT312843	Egr2 Regulation of Gene_expression of Plp1	1	0.31	0.16	0.09	5.00
23	INT312840	Egr2 Regulation of Gene_expression of Mag	1	0.31	0.16	0.09	5.00
24	INT312844	Pou3f1 Regulation of Gene_expression of Pmp22	1	0.27	0.16	0.09	5.00
25	INT312842	Pou3f1 Regulation of Gene_expression of Mag	1	0.24	0.16	0.09	5.00
26	INT312846	Egr2 Regulation of Gene_expression of Pmp22	1	0.35	0.16	0.09	5.00
27	INT312845	Pou3f1 Regulation of Gene_expression of Mbp	1	0.25	0.16	0.09	5.00
28	INT239980	Ts3 Regulation of Nav1	1	0.12	0	0.09	5.00
29	INT309955	Binding of Pkp2 and Dsp	1	0.12	0.1	0	5.00
30	INT309975	Binding of Pygm and Pkp2	1	0.01	0.4	0	5.00
31	INT309956	Binding of Dsc1 and Dsp	1	0.01	0.1	0	5.00
32	INT309976	Binding of Pygm and Dsp	1	0.00	0.1	0	5.00
33	INT309977	Pygm Positive_regulation of Localization of Pkp2	1	0.01	0.19	0	5.00
34	INT309957	Binding of Dsg1b and Dsp	1	0.01	0.1	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nav1.3. They are ordered first by their pain relevance and then by number of times they were reported in Nav1.3. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT97367	Gene_expression of Nav1	243	0.78	132.97	286.66	100.00
2	INT46460	Gene_expression of NAV1	288	0.78	135.51	305.75	100.00
3	INT94450	Gene_expression of Nav1	359	0.78	131.85	275.46	100.00
4	INT100965	Positive_regulation of Nav1	85	0.70	37.74	75.35	100.00
5	INT115909	Positive_regulation of Gene_expression of Nav1	25	0.70	16.58	27.63	100.00
6	INT117674	Regulation of Gene_expression of Nav1	16	0.62	11.5	22.01	100.00
7	INT97366	Regulation of Nav1	38	0.62	23.63	38.17	100.00
8	INT117675	Transcription of Nav1	46	0.72	30.23	44.01	100.00
9	INT97368	Negative_regulation of Nav1	62	0.59	41.56	60.27	100.00
10	INT102429	Negative_regulation of Gene_expression of Nav1	19	0.59	20.09	28.09	100.00
11	INT111052	Positive_regulation of Gene_expression of Nav1	44	0.70	18.98	35.28	100.00
12	INT103262	Localization of Nav1	53	0.81	19.23	34.44	100.00
13	INT116321	Regulation of Nav1	38	0.62	26.62	37.97	100.00
14	INT129303	Positive_regulation of NAV1	54	0.70	36.92	57.45	100.00
15	INT111051	Negative_regulation of Nav1	64	0.59	25.51	47.27	100.00
16	INT145971	Localization of Nav1	20	0.81	10.3	18.11	100.00
17	INT136268	Localization of NAV1	22	0.75	2.84	26.23	100.00
18	INT137043	Transcription of NAV1	16	0.72	6.98	12.12	100.00
19	INT131413	Positive_regulation of Gene_expression of NAV1	35	0.70	17.5	36.83	100.00
20	INT123419	Binding of NAV1	37	0.48	7.09	26.43	100.00
21	INT113384	Regulation of Gene_expression of Nav1	20	0.62	8.57	16.15	100.00
22	INT112207	Binding of Nav1	27	0.47	7.1	15.43	100.00
23	INT111050	Negative_regulation of Gene_expression of Nav1	23	0.58	5.97	17.06	100.00
24	INT116226	Regulation of NAV1	20	0.51	14.32	25.61	100.00
25	INT167435	Positive_regulation of Transcription of NAV1	3	0.70	4.56	5.86	100.00
26	INT103261	Positive_regulation of Nav1	68	0.70	24.25	39.27	100.00
27	INT114507	Negative_regulation of Gene_expression of NAV1	17	0.43	7.24	15.93	100.00
28	INT112640	Positive_regulation of Negative_regulation of Nav1	3	0.50	1.26	2.98	100.00
29	INT153194	Positive_regulation of Positive_regulation of Nav1	5	0.50	3.44	4.24	100.00
30	INT76660	Gene_expression of Trpv1	691	0.78	329.46	386.42	100.00
31	INT74486	Positive_regulation of SCN1A	4	0.67	1	2.2	100.00
32	INT143450	Negative_regulation of Scn5a	3	0.43	2.71	0.88	100.00
33	INT57549	Gene_expression of GNPTAB	49	0.65	57.5	9.05	100.00
34	INT170025	Gene_expression of Fig4	588	0.67	183.27	113.32	100.00
35	INT151387	Gene_expression of Cav3	14	0.78	4	5.31	100.00
36	INT98068	Gene_expression of SCN2A	19	0.75	14.42	3.31	100.00
37	INT99105	Gene_expression of Scn3a	5	0.72	1.82	2.81	100.00
38	INT163962	Regulation of Transcription of Nav1	2	0.35	3.25	2.63	100.00
39	INT104663	Positive_regulation of SCN9A	3	0.60	0.42	2.54	100.00
40	INT13021	Positive_regulation of SCN4A	7	0.49	1.61	2.42	100.00
41	INT169659	Positive_regulation of Gene_expression of Cav3	5	0.70	1.44	2.33	100.00
42	INT153599	Gene_expression of SCN1A	8	0.75	7.01	1.47	100.00
43	INT143451	Negative_regulation of Gene_expression of Scn5a	2	0.43	4.63	1.34	100.00
44	INT278550	Positive_regulation of SCN8A	1	0.48	0	1.31	100.00
45	INT278539	Gene_expression of SCN3A	1	0.74	0	0.98	100.00
46	INT152876	Negative_regulation of Cav2	1	0.34	0.28	0.87	100.00
47	INT77610	Gene_expression of Cacna1h	6	0.65	0.47	0.8	100.00
48	INT278540	Binding of SCN7A	1	0.36	0	0.7	100.00
49	INT148659	Positive_regulation of Scn3a	1	0.06	0.64	0.67	100.00
50	INT129486	Regulation of Gene_expression of Scn3a	1	0.05	0.99	0.61	100.00
51	INT296813	Positive_regulation of Gene_expression of Cacna1h	1	0.06	0.19	0.17	100.00
52	INT151878	Gene_expression of CAV2	18	0.66	9.26	2.17	99.96
53	INT152326	Regulation of Gene_expression of CAV2	2	0.36	0.44	0.74	99.96
54	INT148661	Positive_regulation of LAMB1	2	0.05	0.64	0.67	99.90
55	INT97369	Regulation of Gene_expression of NEUROD1	1	0.26	0.25	1.12	99.84
56	INT101008	Gene_expression of Scn5a	5	0.75	26.93	6.06	99.80
57	INT5757	Gene_expression of SCN4A	6	0.75	1.73	2.73	99.78
58	INT17028	Positive_regulation of Scn7a	35	0.41	9.83	7.44	99.68
59	INT122071	Positive_regulation of Scn7a	1	0.07	0.97	1.6	99.58
60	INT85395	Gene_expression of Scn11a	62	0.78	17.97	26.89	99.56
61	INT129360	Positive_regulation of Gene_expression of Scn11a	2	0.10	0.49	1.01	99.56
62	INT14831	Negative_regulation of TNC	18	0.50	8.71	4.61	99.40
63	INT13409	Gene_expression of NEUROD1	52	0.75	14.17	12.23	99.36
64	INT278541	Positive_regulation of SCN3A	1	0.48	0	1.29	99.36
65	INT6782	Gene_expression of SCN5A	156	0.78	33.13	17.88	99.30
66	INT9556	Negative_regulation of NAV1	47	0.59	28.49	49.33	99.16
67	INT120647	Gene_expression of SCN8A	2	0.74	0.1	1.6	98.82
68	INT48240	Binding of Ngf	46	0.46	23.51	24.42	98.72
69	INT113490	Gene_expression of SCN9A	22	0.77	5.45	12.27	98.34
70	INT64076	Positive_regulation of Kcnma1	47	0.40	11.52	24.19	98.24
71	INT91888	Positive_regulation of Slc7a8	1	0.01	0	1.32	98.24
72	INT89834	Positive_regulation of SCN2A	8	0.49	1.89	2.77	98.16
73	INT141841	Negative_regulation of Transcription of Nav1	3	0.43	3.15	4.38	98.08
74	INT113376	Transcription of Nav1	7	0.69	0.93	6.36	97.88
75	INT78749	Gene_expression of SCN10A	25	0.75	9.23	16.5	97.86
76	INT85214	Gene_expression of SCN11A	24	0.78	4.05	12.5	97.36
77	INT129742	Regulation of Positive_regulation of Rtn4	2	0.05	2.51	2.33	96.80
78	INT278548	Localization of SCN7A	1	0.72	0	0.95	96.72
79	INT6117	Gene_expression of Gmcl1	4	0.49	2.39	2.33	96.52
80	INT278545	Gene_expression of SCN7A	1	0.75	0.12	6.24	96.40
81	INT56239	Positive_regulation of Rtn4	20	0.26	14.05	18.8	96.20
82	INT72252	Gene_expression of Kcnma1	63	0.64	20.47	29.56	96.04
83	INT12124	Gene_expression of MAPK1	141	0.75	82.4	25.58	95.96
84	INT71785	Gene_expression of MAPK3	22	0.75	11.35	8.21	95.96
85	INT38859	Gene_expression of SGSM3	14	0.75	12.98	4.09	95.96
86	INT113385	Negative_regulation of Transcription of Nav1	2	0.43	0.73	2.74	95.88
87	INT90091	Gene_expression of GOPC	967	0.67	366.22	103.6	95.82
88	INT20632	Gene_expression of TNC	72	0.78	30.43	13.16	95.00
89	INT283029	Gene_expression of Mybpc3	1	0.01	0	1.2	94.64
90	INT145515	Positive_regulation of Localization of Trpv1	23	0.50	10.12	12.08	94.48
91	INT231378	Positive_regulation of Localization of Mtcp1	1	0.03	1.08	1.27	94.48
92	INT96622	Localization of Trpv1	110	0.81	59.82	63.25	94.16
93	INT46833	Positive_regulation of SGSM3	56	0.67	24.49	30.31	94.16
94	INT231372	Localization of Mtcp1	1	0.04	1.07	1.27	94.16
95	INT278546	Transcription of GNPTAB	3	0.03	2.19	1.1	94.00
96	INT97200	Transcription of BHLHE22	3	0.52	0.59	1.01	94.00
97	INT278543	Transcription of BHLHE23	1	0.13	0.23	0.43	94.00
98	INT278536	Transcription of OR51B4	1	0.02	0.24	0.43	94.00
99	INT71789	Positive_regulation of MAPK1	396	0.70	234.44	89.27	93.60
100	INT71787	Positive_regulation of MAPK3	37	0.67	17.5	17.88	93.60
101	INT112639	Regulation of LOC682801	4	0.34	0.72	2.58	93.44
102	INT91927	Transcription of LOC682801	6	0.07	1.47	3.93	93.44
103	INT112638	Regulation of Kcnab3	2	0.04	0.25	1.7	93.04
104	INT87753	Transcription of Kcnab3	8	0.55	1.7	4.85	93.04
105	INT3589	Positive_regulation of SCN5A	101	0.57	46.01	21.73	92.96
106	INT86646	Positive_regulation of SCN10A	71	0.69	50.61	13.24	92.96
107	INT236490	Positive_regulation of SCN11A	2	0.48	0.91	2.37	92.96
108	INT83528	Localization of Scn11a	6	0.75	1.51	1.4	92.48
109	INT76487	Localization of Cacna1h	3	0.48	0.98	0.77	92.48
110	INT296811	Gene_expression of Gja4	1	0.24	0.19	0.19	92.48
111	INT239978	Gene_expression of Ts3	1	0.64	0	0.95	91.40
112	INT105154	Regulation of Gene_expression of BHLHE22	2	0.41	0.33	0.83	91.20
113	INT135639	Gene_expression of Ina	3	0.76	9.58	2.89	90.08
114	INT27133	Gene_expression of Nfkbiz	5	0.60	0.74	1.5	90.08
115	INT143448	Gene_expression of Hrasls5	1	0.47	0.08	0.56	90.08
116	INT74983	Transcription of NA	9	0.41	1.71	2.79	89.60
117	INT5430	Gene_expression of Scn8a	37	0.75	4.58	14.82	89.56
118	INT26054	Regulation of Gene_expression of Scn8a	7	0.08	2.86	4.49	89.56
119	INT63025	Gene_expression of BHLHE22	10	0.75	3.79	3.3	89.44
120	INT296805	Positive_regulation of Kcnq1	1	0.49	0.2	0.12	88.40
121	INT5923	Negative_regulation of Rtn4	50	0.36	24.19	27.2	88.36
122	INT67130	Negative_regulation of Localization of Il1b	7	0.57	1.36	6.42	88.24
123	INT66751	Negative_regulation of Localization of Tnf	48	0.59	26	19.36	88.24
124	INT58338	Negative_regulation of Localization of Il1a	8	0.25	3.13	5.18	88.24
125	INT14031	Gene_expression of Npy	107	0.78	36.48	35.4	88.16
126	INT21646	Positive_regulation of Npy	40	0.70	31.31	13.57	88.16
127	INT21794	Positive_regulation of Gene_expression of Npy	20	0.70	8.44	9.3	88.16
128	INT75546	Transcription of Rtn4	1	0.06	2.87	5.03	88.08
129	INT1599	Positive_regulation of ADCY1	146	0.67	30.05	64.9	87.36
130	INT11429	Gene_expression of ADCY1	26	0.74	5.89	11.93	87.36
131	INT251445	Gene_expression of Kcne1	2	0.73	0.61	0.3	87.04
132	INT296817	Positive_regulation of Gene_expression of Kcne1	1	0.66	0.39	0.19	87.04
133	INT10166	Localization of Tnf	237	0.81	153.95	88.64	86.80
134	INT9347	Localization of Il1b	58	0.81	26.13	31.53	86.80
135	INT5966	Localization of Il1a	50	0.78	22.91	26.54	86.80
136	INT13051	Regulation of Kcnma1	12	0.12	2.09	5.06	85.20
137	INT163963	Negative_regulation of Transcription of Rtn4	1	0.03	0.45	1.06	84.24
138	INT171820	Localization of Fig4	144	0.65	27.38	20.88	83.64
139	INT10706	Regulation of Il6	150	0.62	93.23	62.34	83.00
140	INT74286	Regulation of Il10	42	0.44	28.06	19.44	83.00
141	INT112967	Regulation of Mcpt1	15	0.54	13.03	8.58	83.00
142	INT62452	Regulation of Il2	14	0.61	12.11	7.64	83.00
143	INT58484	Regulation of Il4	12	0.45	8.67	6.09	83.00
144	INT52133	Regulation of Localization of Il6	7	0.61	5.35	4.37	83.00
145	INT157048	Regulation of Localization of Mcpt1	3	0.18	0.31	2.73	83.00
146	INT157049	Regulation of Localization of Il4	2	0.25	1.46	2.33	83.00
147	INT127740	Regulation of Localization of Il10	3	0.60	0.65	2.18	83.00
148	INT157050	Regulation of Localization of Il2	1	0.06	0	1.67	83.00
149	INT139350	Binding of SCN1B	2	0.35	1	2.43	82.76
150	INT278537	Binding of SCN2B	1	0.29	0.13	2.29	82.76
151	INT278549	Binding of SCN3B	1	0.34	0.13	2.29	82.76
152	INT278542	Binding of SCN4B	1	0.35	0.13	2.29	82.76
153	INT152877	Negative_regulation of Ndufa10	1	0.02	0.4	0.87	82.72
154	INT19511	Localization of Il6	212	0.81	118.17	67.67	82.40
155	INT72564	Localization of Il10	41	0.78	28.62	17.6	82.40
156	INT110767	Localization of Mcpt1	43	0.68	24.3	16.74	82.40
157	INT50040	Localization of Il4	15	0.67	8.26	7.69	82.40
158	INT12066	Localization of Il2	16	0.75	3.06	5.7	82.40
159	INT53070	Regulation of Rtn4	15	0.22	9.35	13.77	81.64
160	INT117422	Gene_expression of Pirt	13	0.33	2.17	5.23	81.04
161	INT22491	Binding of Atrn	23	0.30	4.51	7.79	79.84
162	INT125624	Gene_expression of Atp8a2	12	0.15	3.91	4.85	79.48
163	INT157666	Positive_regulation of GOPC	335	0.60	120.19	42.75	78.28
164	INT6097	Negative_regulation of NEUROD1	30	0.57	9.71	6.24	77.92
165	INT119748	Negative_regulation of BHLHE22	1	0.13	0.27	0.48	77.92
166	INT10169	Positive_regulation of Localization of Tnf	44	0.70	27.71	16.75	77.88
167	INT48954	Positive_regulation of Localization of Il1b	13	0.53	8.16	6.44	77.88
168	INT5968	Positive_regulation of Localization of Il1a	4	0.65	1.36	2.42	77.88
169	INT6623	Gene_expression of NA	231	0.78	45.78	59.36	77.24
170	INT296810	Negative_regulation of Binding of Kcne1	1	0.40	0.23	0.1	76.92
171	INT98156	Binding of Kcne1	2	0.37	0.32	0.1	76.92
172	INT296808	Negative_regulation of Kcne1	1	0.40	0.23	0.1	76.56
173	INT120836	Positive_regulation of CNTN1	1	0.48	1.42	1.4	75.00
174	INT77601	Gene_expression of OR51B4	15	0.58	2.07	6.19	75.00
175	INT136651	Binding of Calm2	30	0.42	1.09	3.11	75.00
176	INT120843	Gene_expression of CNTN1	7	0.54	4.27	1.06	75.00
177	INT51898	Binding of PECAM1	26	0.36	18.87	4.22	75.00
178	INT57645	Gene_expression of GSTK1	54	0.62	21.05	4.2	75.00
179	INT148658	Negative_regulation of Csnk1a1	2	0.08	0.99	0.75	75.00
180	INT148660	Negative_regulation of Ppp3ca	1	0.02	0.59	0.67	75.00
181	INT120839	Binding of CNTN1	2	0.34	0.75	0.52	75.00
182	INT120838	Positive_regulation of Gene_expression of CNTN1	1	0.35	0.45	0.48	75.00
183	INT120844	Negative_regulation of CNTN1	2	0.26	0.52	0.47	75.00
184	INT120841	Positive_regulation of Localization of CNTN1	1	0.35	0.52	0.46	75.00
185	INT120842	Localization of CNTN1	1	0.52	0.52	0.46	75.00
186	INT137836	Negative_regulation of Binding of Calm2	2	0.51	0	0.23	75.00
187	INT33170	Binding of Chrm1	11	0.48	1.58	2.1	73.84
188	INT296815	Regulation of Gene_expression of Kcne1	1	0.43	0.19	0.07	73.44
189	INT73335	Gene_expression of ACTB	21	0.58	5.62	1.94	72.92
190	INT48312	Gene_expression of NTRK1	72	0.78	38.21	22.24	72.64
191	INT96492	Gene_expression of NGFR	24	0.00	12.3	4.59	72.64
192	INT111049	Negative_regulation of Positive_regulation of Nav1	5	0.43	4.39	6.25	72.08
193	INT31796	Gene_expression of Enpep	5	0.65	0.42	2.32	71.92
194	INT32786	Localization of Enpep	4	0.68	0	1.16	71.92
195	INT48008	Negative_regulation of Pde6b	9	0.15	6.12	4.11	71.68
196	INT4449	Positive_regulation of NA	179	0.55	40.26	37.82	70.16
197	INT111053	Positive_regulation of Positive_regulation of Nav1	4	0.46	2.97	3.53	69.64
198	INT117676	Positive_regulation of Transcription of Nav1	8	0.53	4.37	7.75	66.24
199	INT95787	Positive_regulation of Mapk1	568	0.70	226.51	220.94	65.76
200	INT59671	Positive_regulation of Scn8a	7	0.39	1.88	5.92	65.04