P:Opioid receptor 1

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pChart

Pain Term
Category Molecule
Synonyms Mu Opiate Receptor, Mu Opioid Receptor HMOR-1a, Mu-type Opioid Receptor, Opioid Receptor Mu 1
Pain Specific Yes
Documents 152
Hot Single Events 138
Hot Interactions 15

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Opioid receptor 1. They are ordered first by their pain relevance and then by number of times they were reported for Opioid receptor 1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08 100.00
2 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08 100.00
3 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74 100.00
4 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41 100.00
5 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36 100.00
6 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31 100.00
7 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03 100.00
8 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98 100.00
9 INT157297 Npy Regulation of Npy1r 1 0.18 0.19 0.82 100.00
10 INT123465 Oprl1 Positive_regulation of ATP5G3 1 0.22 0 0.57 100.00
11 INT68540 Penk Regulation of Ndst4 1 0.00 0.35 0.5 100.00
12 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1 98.70
13 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 98.22
14 INT100816 PPP1R14C Regulation of Ppp1cc 1 0.08 0 1.27 95.48
15 INT100806 Ppp1r14a Regulation of Ppp1cc 1 0.05 0 0.65 94.20
16 INT152361 Binding of Ifng and T2dm2 1 0.00 0.86 0.37 77.72
17 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76 75.00
18 INT342744 Ddc Regulation of Trh 1 0.02 0.37 0.18 62.08
19 INT41108 Adarb1 Positive_regulation of Localization of Ins1 1 0.03 0 0.81 59.16
20 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57 5.00
21 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
22 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
23 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2 5.00
24 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11 5.00
25 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82 5.00
26 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82 5.00
27 INT206609 Binding of Col7a1 and Ecm1 1 0.00 0.47 0.33 5.00
28 INT206608 Binding of Ecm1 and Itgb5 1 0.02 0.41 0.33 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Opioid receptor 1. They are ordered first by their pain relevance and then by number of times they were reported in Opioid receptor 1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 100.00
2 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
3 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 100.00
4 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 100.00
5 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
6 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 100.00
7 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 100.00
8 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 100.00
9 INT96039 Regulation of Rasgrp1 1 0.37 0.44 1.36 100.00
10 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 100.00
11 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 100.00
12 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
13 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
14 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
15 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 100.00
16 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38 100.00
17 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75 100.00
18 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 100.00
19 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
20 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
21 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69 100.00
22 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 100.00
23 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 100.00
24 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 100.00
25 INT149055 Gene_expression of Plxnd1 1 0.04 0.17 0.3 100.00
26 INT29561 Binding of GSTM1 35 0.48 25.86 6.24 100.00
27 INT72237 Binding of AP1M2 3 0.25 0 1.94 100.00
28 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 100.00
29 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79 100.00
30 INT8757 Binding of ACHE 10 0.48 5.84 1.72 100.00
31 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 100.00
32 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
33 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 100.00
34 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 100.00
35 INT14137 Localization of Oprm1 56 0.81 2.88 36.09 100.00
36 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 100.00
37 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 100.00
38 INT1590 Binding of PENK 27 0.47 2.99 12.81 100.00
39 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95 100.00
40 INT5481 Binding of TYR 26 0.47 1.3 7.95 100.00
41 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75 100.00
42 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 100.00
43 INT52796 Regulation of Guca2a 2 0.44 0 1.12 100.00
44 INT68536 Regulation of Ndst4 1 0.00 0.35 0.5 100.00
45 INT33368 Positive_regulation of Regulation of Oprl1 1 0.50 0 0.27 100.00
46 INT76649 Gene_expression of TRIM54 12 0.22 1.91 5.55 99.96
47 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 99.96
48 INT119084 Binding of TRIM54 1 0.01 0 1.19 99.96
49 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 99.80
50 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91 99.80
51 INT123464 Binding of ATP5G3 3 0.18 1.92 0.79 99.72
52 INT123463 Gene_expression of ATP5G3 5 0.37 2.25 0.75 99.72
53 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.56
54 INT123643 Gene_expression of Reln 19 0.75 1.85 1.13 99.56
55 INT140720 Negative_regulation of Reln 5 0.57 2.43 0.95 99.56
56 INT108363 Gene_expression of Chrm4 4 0.45 0.09 0.15 99.24
57 INT108369 Negative_regulation of Chrm4 2 0.32 0.09 0.15 99.24
58 INT149056 Gene_expression of Foxp1 1 0.12 0.09 0.15 98.96
59 INT149057 Negative_regulation of Foxp1 1 0.03 0.09 0.15 98.96
60 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 98.88
61 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 98.70
62 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 98.70
63 INT4737 Gene_expression of Ppp1r1b 29 0.67 5.73 9.83 98.68
64 INT120468 Negative_regulation of Ppp1r1b 10 0.50 2.55 6.56 98.68
65 INT1376 Binding of Trh 121 0.48 20 69.86 98.44
66 INT96038 Positive_regulation of Rasgrp1 2 0.30 0.55 0.17 98.44
67 INT100805 Binding of Ppp1cc 7 0.47 1.77 2.23 98.24
68 INT100802 Binding of Ppp1r14a 1 0.08 0 0.7 98.24
69 INT1510 Binding of PDYN 94 0.48 4.68 56.44 98.22
70 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 98.00
71 INT6765 Localization of Oprl1 49 0.81 5.11 28.87 98.00
72 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 97.84
73 INT54682 Positive_regulation of Regulation of PDYN 1 0.17 0 1.09 97.68
74 INT403 Localization of Trh 241 0.81 28.55 81.45 97.52
75 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 97.48
76 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 97.32
77 INT54275 Gene_expression of Olr1750 1 0.53 0 0.73 97.20
78 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 97.12
79 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06 96.88
80 INT54276 Binding of Olr1750 1 0.33 0 0.73 96.68
81 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 96.68
82 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 96.36
83 INT107113 Gene_expression of Pld1 6 0.78 2.71 4.28 96.28
84 INT1114 Localization of Ins1 748 0.80 192.95 165.48 96.16
85 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 96.08
86 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92 96.08
87 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 96.00
88 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 96.00
89 INT23784 Gene_expression of FAIM3 25 0.55 2.89 17.14 95.92
90 INT98702 Positive_regulation of Gene_expression of FAIM3 4 0.31 0.48 3.11 95.92
91 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73 95.88
92 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78 94.76
93 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 94.76
94 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43 94.40
95 INT62089 Phosphorylation of FAIM3 14 0.63 0.62 10.05 94.32
96 INT1005 Localization of Sst 385 0.81 26.31 244.56 94.08
97 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 94.00
98 INT2541 Binding of Calca 200 0.48 67.14 134.62 93.56
99 INT148894 Binding of Cytl1 2 0.47 0.99 0.77 92.92
100 INT62088 Regulation of Phosphorylation of FAIM3 3 0.35 0.1 3 92.64
101 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 92.28
102 INT36726 Regulation of Gene_expression of Ltp 14 0.46 4.81 7.05 92.28
103 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 92.08
104 INT462 Regulation of Pomc 157 0.62 41.67 67.27 91.72
105 INT2499 Positive_regulation of Sult1b1 51 0.43 2.83 32.38 91.24
106 INT100812 Phosphorylation of PPP1R14C 1 0.71 0 2.45 91.08
107 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 90.76
108 INT31760 Negative_regulation of Itpr3 5 0.23 0.84 1.61 90.24
109 INT55577 Negative_regulation of Gene_expression of Itpr3 1 0.06 0 0.39 90.24
110 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 89.40
111 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 89.12
112 INT57719 Localization of GPM6A 7 0.44 0.95 5.97 88.88
113 INT117512 Negative_regulation of Localization of GPM6A 2 0.08 0.07 2.25 88.88
114 INT5372 Localization of LHB 55 0.68 9.47 19 88.44
115 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08 88.44
116 INT443 Localization of POMC 1020 0.81 284.52 443.17 88.40
117 INT31762 Gene_expression of Itpr3 22 0.74 1.6 4.15 88.24
118 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 87.88
119 INT4631 Positive_regulation of Sst 127 0.70 17.37 83.29 87.88
120 INT7280 Positive_regulation of Localization of Sst 97 0.70 5.64 63.37 87.88
121 INT100811 Positive_regulation of PPP1R14C 1 0.35 0 0.62 87.04
122 INT68542 Negative_regulation of Positive_regulation of ANTXRL 1 0.00 0.46 0.57 86.88
123 INT29938 Positive_regulation of ANTXRL 7 0.07 1.83 2.86 86.88
124 INT14453 Localization of Mme 44 0.80 2.46 14.75 86.88
125 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 85.68
126 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 85.64
127 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14 85.64
128 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 84.80
129 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 84.04
130 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 83.68
131 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 82.88
132 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 82.48
133 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 80.88
134 INT40866 Binding of Acvrl1 1 0.30 0 0.71 80.76
135 INT80871 Negative_regulation of Binding of ADCY1 1 0.03 0.1 0.91 80.64
136 INT158 Localization of Prl 2431 0.81 378.96 952.2 80.16
137 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 80.16
138 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 80.16
139 INT30815 Binding of ADCY1 7 0.36 0.21 2.79 79.92
140 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 79.68
141 INT100815 Positive_regulation of Gene_expression of PPP1R14C 1 0.52 0 0.66 79.52
142 INT100814 Gene_expression of PPP1R14C 1 0.58 0 1.23 78.84
143 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 78.84
144 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23 78.84
145 INT149063 Regulation of BCL11B 1 0.11 0.06 0.12 78.44
146 INT16735 Localization of Drd1a 11 0.61 0.35 8.42 77.80
147 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 77.72
148 INT67078 Binding of Ifng 7 0.48 4.84 2.73 77.72
149 INT20925 Binding of ANTXR1 15 0.01 4.2 3.8 77.12
150 INT100809 Transcription of PPP1R14C 1 0.40 0 0.57 76.80
151 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 76.48
152 INT7674 Regulation of ENG 42 0.30 11.41 14.44 75.96
153 INT25029 Positive_regulation of Positive_regulation of CRH 7 0.49 6.77 3.52 75.80
154 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 75.44
155 INT9490 Regulation of Mme 44 0.56 6.69 19.21 75.32
156 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 75.00
157 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 75.00
158 INT7055 Positive_regulation of Binding of FAIM3 4 0.34 1.22 4.34 75.00
159 INT82166 Regulation of NOS3 14 0.54 7.57 2.08 75.00
160 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 75.00
161 INT1396 Binding of Penk 355 0.48 22.79 269.65 75.00
162 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27 75.00
163 INT20575 Gene_expression of Akr1d1 48 0.57 6.2 22.5 75.00
164 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86 75.00
165 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 75.00
166 INT12823 Positive_regulation of FAIM3 9 0.64 3.23 4.76 75.00
167 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 75.00
168 INT28412 Gene_expression of SUPT7L 6 0.75 0.79 2.12 75.00
169 INT96797 Negative_regulation of ITIH4 5 0.42 3.21 1.8 75.00
170 INT56060 Gene_expression of RTCA 3 0.05 0.76 1.27 75.00
171 INT38119 Gene_expression of TUBB4A 6 0.65 0.74 1.21 75.00
172 INT99110 Regulation of Gene_expression of FAIM3 1 0.16 0 0.25 75.00
173 INT99109 Negative_regulation of Gene_expression of FAIM3 1 0.15 0 0.25 75.00
174 INT88993 Gene_expression of PSMB7 2 0.01 0.62 0.24 75.00
175 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 74.56
176 INT41106 Gene_expression of Camp 2 0.75 0.24 0.64 74.24
177 INT41105 Regulation of Gene_expression of Camp 1 0.44 0 0.64 74.24
178 INT7282 Regulation of Localization of Sst 58 0.62 1.92 34.83 73.64
179 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 72.88
180 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92 71.12
181 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 70.80
182 INT18755 Positive_regulation of Rvm 79 0.60 60 92.93 70.60
183 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 70.24
184 INT2500 Negative_regulation of Positive_regulation of Sult1b1 13 0.18 0.6 8.6 69.24
185 INT100804 Regulation of Gene_expression of Ppp1cc 2 0.18 0 0.6 68.40
186 INT100813 Regulation of Gene_expression of PPP1R14C 1 0.46 0 0.57 68.40
187 INT100803 Regulation of Phosphorylation of Ppp1cc 1 0.10 0 0.57 68.40
188 INT100808 Regulation of Phosphorylation of PPP1R14C 1 0.34 0 0.57 68.40
189 INT90276 Gene_expression of Ppp1cc 10 0.73 0.83 2.87 67.84
190 INT98457 Phosphorylation of Ppp1cc 11 0.33 0.12 2.57 67.16
191 INT57425 Binding of MYH14 12 0.11 2.33 1.26 67.12
192 INT2501 Positive_regulation of Positive_regulation of Sult1b1 19 0.19 2.38 7.16 65.24
193 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 64.00
194 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 63.60
195 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 62.64
196 INT339 Regulation of Trh 156 0.62 39.27 83.55 60.76
197 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 60.76
198 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 60.16
199 INT1308 Localization of Pomc 457 0.81 66.83 217.5 60.16
200 INT10799 Localization of ENG 63 0.78 18.67 27.28 60.16
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