P:Oxycodone

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pChart
Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 1044
Hot Single Events 172
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Oxycodone. They are ordered first by their pain relevance and then by number of times they were reported for Oxycodone. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27 100.00
2 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27 100.00
3 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38 100.00
4 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27 99.84
5 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27 99.04
6 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02 92.60
7 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75 80.12
8 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 0.19 0.26 1.75 80.12
9 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75 80.12
10 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34 69.92
11 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22 69.20
12 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57 67.28
13 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65 66.68
14 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0 50.00
15 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63 45.80
16 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63 45.80
17 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 32.72
18 INT150148 Binding of CISH and Myoz1 1 0.01 0.7 0.68 25.00
19 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48 25.00
20 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 20.48
21 INT259209 Binding of Glul and Flna 1 0.03 0 4.2 8.56
22 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39 8.56
23 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15 5.00
24 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 5.00
25 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64 5.00
26 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64 5.00
27 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08 5.00
28 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
29 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
30 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8 5.00
31 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33 5.00
32 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
33 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23 5.00
34 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12 5.00
35 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
36 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 5.00
37 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45 5.00
38 INT199285 Tg(Foxn1)E1Hon Regulation of Gene_expression of Mapt 1 0.01 0.52 0.36 5.00
39 INT199286 Tg(Foxn1)E1Hon Regulation of Gene_expression of Oprm1 1 0.13 0.32 0.28 5.00
40 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 5.00
41 INT199284 Binding of Polr2a and Vmn1r66 1 0.00 0.19 0.11 5.00
42 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
43 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 5.00
44 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0 5.00
45 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0 5.00
46 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0 5.00
47 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0 5.00
48 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 0.16 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Oxycodone. They are ordered first by their pain relevance and then by number of times they were reported in Oxycodone. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 100.00
2 INT106097 Localization of pr 20 0.62 12.01 19.46 100.00
3 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 100.00
4 INT39906 Gene_expression of ALKBH2 2 0.21 1.34 2.94 100.00
5 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 100.00
6 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 100.00
7 INT139613 Binding of pr 16 0.47 5.52 8.46 100.00
8 INT122920 Gene_expression of MSN 2 0.65 0.19 0.99 100.00
9 INT2893 Localization of Oxt 219 0.80 28.96 79.43 100.00
10 INT39000 Regulation of pr 24 0.44 12.51 4.36 100.00
11 INT10340 Regulation of Localization of Oxt 30 0.60 2.55 14.3 100.00
12 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 100.00
13 INT2038 Localization of Esr1 104 0.79 40.12 13.27 100.00
14 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 100.00
15 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 99.98
16 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.98
17 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6 99.98
18 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.98
19 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 99.98
20 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.98
21 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 99.98
22 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 99.98
23 INT39905 Positive_regulation of ALKBH2 7 0.16 2.1 5.77 99.96
24 INT10344 Localization of Jun 23 0.73 6.36 7.46 99.96
25 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 99.94
26 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 99.92
27 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 99.90
28 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 99.84
29 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 99.84
30 INT69314 Binding of CYP3A 16 0.48 1.78 2.19 99.84
31 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7 99.84
32 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 99.82
33 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.76
34 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 99.74
35 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 99.74
36 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.74
37 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 99.72
38 INT58109 Positive_regulation of Positive_regulation of MPG 2 0.49 0.37 1.42 99.72
39 INT58108 Positive_regulation of Positive_regulation of ALB 4 0.70 1.02 2.11 99.72
40 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 99.72
41 INT83236 Localization of PGR 14 0.73 8.26 2.23 99.72
42 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.68
43 INT318255 Gene_expression of SDCCAG3 1 0.05 0 4.24 99.66
44 INT318257 Positive_regulation of Gene_expression of SDCCAG3 1 0.03 0 0.33 99.66
45 INT167050 Negative_regulation of Gt(pU21)50Imeg 1 0.01 0 2.28 99.64
46 INT168325 Gene_expression of Gsta5 1 0.20 0 1.13 99.62
47 INT39846 Gene_expression of Olr1746 12 0.75 0.61 3.22 99.62
48 INT61243 Gene_expression of Cyp3a2 3 0.66 2.25 0.86 99.62
49 INT22794 Regulation of Gt(pU21)50Imeg 4 0.02 0.14 7.45 99.60
50 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.58
51 INT110202 Positive_regulation of Gene_expression of Abcb1a 13 0.67 2.08 5.01 99.56
52 INT26218 Gene_expression of Gt(pU21)50Imeg 3 0.02 0.26 4.63 99.56
53 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.54
54 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.46
55 INT114412 Localization of HCL1 18 0.56 3.69 2.96 99.46
56 INT160994 Negative_regulation of St13 9 0.20 4.83 3.71 99.44
57 INT318254 Binding of YTHDF2 1 0.05 0 0.77 99.44
58 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 99.44
59 INT19109 Positive_regulation of CYP3A5 7 0.67 1.48 1.51 99.44
60 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 99.42
61 INT19538 Positive_regulation of MPG 8 0.67 3.21 3.57 99.42
62 INT105754 Regulation of St13 8 0.28 0.75 11.41 99.40
63 INT129585 Gene_expression of St13 17 0.59 4.46 9.3 99.36
64 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 99.30
65 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 99.30
66 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 99.28
67 INT119909 Binding of Abcb1a 10 0.36 0.76 5.07 99.24
68 INT318253 Gene_expression of YTHDF2 1 0.09 0 1.04 99.22
69 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 99.14
70 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 99.02
71 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 99.02
72 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 99.02
73 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 99.02
74 INT318256 Binding of SDCCAG3 1 0.02 0 0.48 99.02
75 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 99.00
76 INT159864 Localization of CYP3A5 2 0.73 0.33 0.52 98.94
77 INT125979 Gene_expression of Olr833 1 0.36 0 0.86 98.86
78 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 98.82
79 INT8733 Localization of Oprm1 61 0.75 7.55 64.61 98.80
80 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 98.64
81 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 98.60
82 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 98.60
83 INT7872 Positive_regulation of P9Ehs1 74 0.50 18.54 66.16 98.48
84 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 98.48
85 INT126342 Negative_regulation of ST6GALNAC5 1 0.02 0 0.48 98.40
86 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 98.38
87 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 98.36
88 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 98.26
89 INT125978 Negative_regulation of Olr833 4 0.26 0.88 1.37 98.24
90 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 98.14
91 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67 98.12
92 INT50581 Regulation of PPIG 26 0.55 8.96 4.32 98.12
93 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35 97.92
94 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 97.82
95 INT4153 Binding of Insrr 109 0.40 17.99 72.15 97.80
96 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 97.80
97 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42 97.56
98 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 97.52
99 INT47044 Positive_regulation of ORM1 5 0.68 0.58 4.46 97.44
100 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 97.36
101 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68 97.36
102 INT1438 Localization of Pomc 360 0.81 101.26 116.47 97.32
103 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33 97.28
104 INT168323 Positive_regulation of Gene_expression of Gsta5 1 0.15 0 0.56 97.16
105 INT168327 Positive_regulation of Gene_expression of Olr1746 2 0.45 0 0.75 97.16
106 INT55516 Gene_expression of Cyp2d1 5 0.60 0.83 3.58 97.04
107 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 96.92
108 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 96.92
109 INT102822 Negative_regulation of MS2 1 0.35 0 1 96.70
110 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 96.68
111 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83 96.16
112 INT232662 Localization of MS 1 0.03 0.57 1.95 96.00
113 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 95.96
114 INT80981 Regulation of Abcb1a 19 0.62 1.86 7.2 95.84
115 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43 95.56
116 INT58107 Negative_regulation of MPG 2 0.41 0.92 0.98 95.52
117 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 95.52
118 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 95.52
119 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 94.92
120 INT85616 Negative_regulation of Positive_regulation of P9Ehs1 8 0.37 4.17 8.11 94.92
121 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74 94.88
122 INT930 Regulation of Spic 2 0.38 0.53 1.52 94.68
123 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 94.48
124 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 94.16
125 INT318259 Positive_regulation of SDCCAG3 1 0.04 0 0.09 93.84
126 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9 93.52
127 INT160885 Positive_regulation of Regulation of ROS1 1 0.18 0.06 0.84 93.48
128 INT167049 Binding of Ednra 3 0.07 3.47 6.84 93.40
129 INT318252 Negative_regulation of Gene_expression of SDCCAG3 1 0.03 0 0.6 93.28
130 INT318260 Positive_regulation of Binding of YTHDF2 1 0.07 0 0.09 93.20
131 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 93.00
132 INT39281 Regulation of DECR1 3 0.44 0.14 0.89 93.00
133 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 92.60
134 INT85080 Positive_regulation of Positive_regulation of P9Ehs1 21 0.50 4.51 19.53 92.56
135 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 92.36
136 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 92.00
137 INT318251 Negative_regulation of SDCCAG3 1 0.03 0 0.3 91.76
138 INT82441 Binding of Cyp4f18 4 0.23 1.07 1.99 91.76
139 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36 91.64
140 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18 91.24
141 INT56686 Regulation of Vta1 26 0.44 3.43 24.48 91.24
142 INT71995 Binding of Crygs 54 0.11 10.03 39.31 91.08
143 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85 90.16
144 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16 90.12
145 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 89.76
146 INT109313 Binding of Mapk8 6 0.48 1.78 1.98 89.76
147 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62 89.76
148 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49 89.56
149 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 89.44
150 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 89.36
151 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 88.64
152 INT267800 Regulation of Gene_expression of RLS 2 0.29 3.79 1.07 88.60
153 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 88.52
154 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 88.20
155 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 87.76
156 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 87.16
157 INT334926 Positive_regulation of MEHMO 1 0.02 10.11 2.37 85.48
158 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 85.32
159 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07 84.92
160 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 84.00
161 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 83.68
162 INT311487 Regulation of Regulation of RLS 1 0.26 2.7 1.76 83.60
163 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 83.40
164 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 83.40
165 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36 83.40
166 INT142735 Regulation of RLS 33 0.53 45.83 11.35 83.28
167 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 82.80
168 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 82.36
169 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 82.32
170 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 81.96
171 INT130672 Binding of Ugt2b7 2 0.22 0.38 2.71 81.80
172 INT199591 Protein_catabolism of IL2 2 0.05 1.2 1.81 81.56
173 INT187888 Binding of Pgp 5 0.32 0.4 1.35 79.80
174 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 77.64
175 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 77.28
176 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 77.28
177 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 77.28
178 INT3546 Binding of Oxt 54 0.48 9.75 10.81 77.20
179 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 76.56
180 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 76.20
181 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 75.64
182 INT157430 Gene_expression of Ephb6 18 0.70 8.13 7.14 75.00
183 INT157429 Negative_regulation of Ephb6 3 0.35 2.17 2.77 75.00
184 INT148389 Regulation of Localization of Csda 1 0.26 0.63 0.52 75.00
185 INT148388 Localization of Csda 1 0.47 0.63 0.52 75.00
186 INT318262 Positive_regulation of PSMC1 1 0.03 0 0.2 74.68
187 INT110987 Transcription of ESR1 45 0.71 24.16 6.72 74.48
188 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56 73.16
189 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06 73.04
190 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 72.28
191 INT158070 Localization of Aes 23 0.65 19.93 10.9 71.84
192 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8 71.84
193 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 70.60
194 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 70.44
195 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 69.92
196 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 69.76
197 INT211228 Localization of Serpind1 3 0.63 6.11 0.51 69.68
198 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38 69.08
199 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 69.04
200 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 68.60
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