P:central nervous system

This page displays the top molecular interactions and top single events that were mentioned in the literature for central nervous system. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for central nervous system. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT17456	Binding of CSF2 and POMC	3	0.32	4.06	3.15	1.20
2	INT181436	Binding of Ccl2 and Eae1	1	0.05	5.14	1.27	1.17
3	INT188692	Binding of Cd40 and Cd40lg	32	0.34	22.95	6.62	1.11
4	INT157767	Binding of TLR4 and LY96	8	0.54	4.05	1.95	1.09
5	INT149492	PNOC Negative_regulation of Gene_expression of CCL2	1	0.15	0.68	3.17	1.02
6	INT181434	Binding of Ccr2 and Ccl2	1	0.27	6.06	1.04	0.95
7	INT159962	Rock2 Regulation of Localization of Il6	1	0.09	2.7	0.88	0.86
8	INT10276	Il1b Regulation of Gene_expression of Penk	1	0.61	0.85	1.5	0.82
9	INT288700	Binding of Cp and Tfrc	1	0.40	0	0.39	0.78
10	INT149494	PNOC Negative_regulation of Gene_expression of CCL5	1	0.19	0.52	2.46	0.74
11	INT33314	Binding of Ap1m1 and Ap1m2	1	0.07	0.97	5.42	0.74
12	INT240808	Arc Regulation of Ins1	1	0.09	1.41	0.54	0.73
13	INT282712	Binding of MUC5AC and Csf2	1	0.01	2.63	1.07	0.71
14	INT159963	Tnf Positive_regulation of Localization of Il6	1	0.12	2.32	0.71	0.69
15	INT181453	Gene_expression of Ccl2 Positive_regulation of Gene_expression of Il12rb1	1	0.06	1.87	0.34	0.68
16	INT140172	Binding of Nqo1 and IgG	5	0.17	6.68	1.2	0.68
17	INT3573	Tf Negative_regulation of Localization of Gh1	1	0.36	0	1.49	0.67
18	INT27932	Binding of CCK and NCOR2	1	0.01	0.91	1.47	0.64
19	INT189999	Binding of Vta1 and Cfp	2	0.08	1.25	1.97	0.63
20	INT220623	Binding of Stat1 and Bace1	11	0.25	10.33	3.81	0.61
21	INT216043	Binding of Rtn4r and Lingo1	1	0.15	0.82	0.3	0.60
22	INT66535	Binding of Pnoc and Oprl1	43	0.54	5.93	32.4	0.60
23	INT122567	Mog Positive_regulation of Eae1	8	0.31	10.18	4.26	0.59
24	INT106559	Binding of Bdnf and Ntrk2	23	0.43	11.09	7.33	0.54
25	INT197496	Binding of Apoe and Lrp1	4	0.22	2.32	0.46	0.53
26	INT28235	Binding of Cck and Gast	5	0.38	0.73	2.96	0.53
27	INT356233	Slc32a1 Positive_regulation of Gabrg1	1	0.17	1.6	1.44	0.52
28	INT206764	Binding of AQP4 and Nqo1	8	0.05	13.45	2.84	0.51
29	INT189197	RASGRP1 Positive_regulation of JUN	1	0.07	1.26	0.43	0.51
30	INT250248	Binding of AQP4 and SLC1A3	1	0.11	1.55	0.77	0.50
31	INT275398	Binding of ITIH4 and Htatsf1	1	0.02	5.05	2.24	0.47
32	INT149491	PNOC Negative_regulation of Gene_expression of CD14	1	0.40	0.37	1.76	0.46
33	INT208354	Binding of Apoe and Hdl1	12	0.13	8.37	0.77	0.45
34	INT175805	Crh Positive_regulation of Gene_expression of POMC	1	0.12	1.07	0.99	0.45
35	INT154237	Binding of CYP2D6 and Ugt2b7	1	0.41	0.75	1	0.43
36	INT332538	Binding of AD5 and Cxadr	1	0.08	0.98	0.76	0.43
37	INT154236	Binding of TBX3 and Ugt2b7	1	0.41	0.74	1	0.43
38	INT188746	Binding of CSF2 and HIVEP1	1	0.04	3.99	0.21	0.42
39	INT273045	Vip Regulation of Adcyap1	1	0.17	0.5	0.38	0.42
40	INT59547	Avp Positive_regulation of Crh	2	0.14	1.13	1.47	0.42
41	INT43509	Avp Positive_regulation of Localization of POMC	2	0.13	1.26	1.16	0.42
42	INT40153	Gnrh1 Regulation of Trh	1	0.47	0	0.59	0.42
43	INT10275	Il1b Positive_regulation of Gene_expression of Penk	1	0.49	0.75	0.83	0.42
44	INT235956	Binding of Aqp4 and NMO-IgG	1	0.04	4.53	0.5	0.41
45	INT127128	Binding of CNR1 and CNR2	8	0.39	3.98	3.97	0.40
46	INT297547	Pou3f3 Regulation of Psen1	1	0.00	0.41	0.25	0.40
47	INT297545	Pou3f3 Regulation of Hes1	1	0.05	0.41	0.2	0.40
48	INT297544	Pou3f3 Regulation of Notch1	1	0.06	0.41	0.2	0.40
49	INT235959	Nqo1 Positive_regulation of Localization of Aqp4	1	0.02	1.39	0.26	0.40
50	INT3571	Sst Regulation of Negative_regulation of Gh1	1	0.24	0	0.42	0.39
51	INT181448	Eae1 Positive_regulation of Gene_expression of Ccr2	1	0.04	4.98	0.42	0.39
52	INT90644	Slc6a3 Positive_regulation of Th	1	0.51	0	1.2	0.38
53	INT221955	Binding of ELAVL1 and CDK5R1	1	0.01	0.93	0.19	0.38
54	INT240807	Arc Regulation of Gene_expression of Lepr	1	0.05	0.72	0.28	0.38
55	INT108810	Esr1 Positive_regulation of Binding of Oprm1	1	0.51	1.79	3.22	0.38
56	INT181451	Lck Regulation of Mbp	1	0.08	1.43	0.34	0.37
57	INT196586	Negative_regulation of Mapk14 Negative_regulation of TNF	2	0.04	2.02	2.08	0.37
58	INT256586	Binding of RBP4 and TTR	1	0.07	1.92	0.18	0.36
59	INT333758	Hand1 Positive_regulation of Eae1	1	0.05	1.6	0.22	0.36
60	INT282711	Binding of Csf2 and Mmp9	1	0.16	1.35	0.54	0.36
61	INT333762	Positive_regulation of thd Positive_regulation of Eae1	1	0.00	1.6	0.22	0.36
62	INT333760	thd Positive_regulation of Eae1	1	0.00	1.6	0.22	0.36
63	INT282713	Binding of MUC5AC and Mmp9	1	0.02	1.27	0.52	0.35
64	INT14781	Cck Regulation of Gast	3	0.38	0.28	2.3	0.34
65	INT298999	Binding of Il18bp and Il18	1	0.02	0	0.45	0.34
66	INT47956	Cck Positive_regulation of Gast	1	0.02	0.09	1.25	0.34
67	INT208360	Binding of Abca1 and Apoe	1	0.15	0.74	0.17	0.34
68	INT237778	Il12b Positive_regulation of Gene_expression of Eae1	1	0.01	1.51	0.39	0.34
69	INT251146	Binding of Grin1 and Dlg2	1	0.36	1.95	3.16	0.33
70	INT250251	Binding of SLC1A2 and SLC1A3	1	0.09	1.12	0.43	0.32
71	INT29446	Crh Positive_regulation of Localization of POMC	8	0.38	1.87	2.58	0.32
72	INT246971	Binding of Clns1a and Csf2	1	0.10	1.31	0.22	0.31
73	INT216042	Binding of Rtn4r and Gtf3a	1	0.01	0.41	0.15	0.30
74	INT144343	Binding of Npffr2 and Qrfp	1	0.37	0	0.37	0.30
75	INT216041	Binding of Tnfrsf1b and Rtn4r	1	0.10	0.75	0.2	0.30
76	INT285911	Binding of TLR4 and Cd14	1	0.05	1.13	0.51	0.29
77	INT181440	Binding of Ccr2 and Eae1	1	0.03	1.3	0.19	0.29
78	INT327182	Binding of Mpl and Thpo	1	0.41	0.54	0.37	0.29
79	INT235971	Positive_regulation of Binding of Nqo1 and NMO-IgG	1	0.00	1.86	0.32	0.29
80	INT237633	Cntn1 Regulation of Gene_expression of Ank3	1	0.00	0.23	0.33	0.29
81	INT237637	Cntn1 Positive_regulation of Gene_expression of Ank3	1	0.00	0.23	0.33	0.29
82	INT77646	Binding of Ngf and Ntrk1	23	0.40	7.85	9.26	0.29
83	INT237640	Nfasc Regulation of Gene_expression of Ank3	1	0.01	0.23	0.32	0.29
84	INT237634	Nfasc Positive_regulation of Gene_expression of Ank3	1	0.02	0.23	0.32	0.29
85	INT149493	PNOC Negative_regulation of CCL5	1	0.14	0.16	0.77	0.28
86	INT149495	PNOC Negative_regulation of CCL2	1	0.11	0.16	0.77	0.28
87	INT302553	Binding of CD8A and MID1	1	0.01	0.38	0.17	0.28
88	INT69163	Tlr4 Positive_regulation of Ptgs1	1	0.02	0.08	0.44	0.28
89	INT275390	Binding of Ccr5 and Htatsf1	1	0.01	3.26	0.97	0.28
90	INT67440	Pdyn Regulation of Gene_expression of Tnf	1	0.23	0.19	0.48	0.28
91	INT275386	Binding of Cxcr4 and Htatsf1	1	0.01	3.25	0.97	0.28
92	INT250253	Binding of AQP4 and SLC1A2	1	0.30	2.95	1.09	0.27
93	INT240537	Binding of Il12a and Ebi3	1	0.08	1.23	0.49	0.27
94	INT251170	Clu Positive_regulation of Trpv1	1	0.28	2.61	6.49	0.27
95	INT251147	Binding of Grin2b and Dlg2	1	0.33	2.75	2.43	0.27
96	INT350701	Mthfd1 Regulation of Gene_expression of Cd4	1	0.03	1.46	0.33	0.27
97	INT72264	Binding of Hrh1 and Hrh3	1	0.11	0.16	0.34	0.27
98	INT206535	Binding of Trem2 and Tg(CAG-EGFP)D4Nagy	1	0.03	0.5	0.27	0.27
99	INT33985	Binding of Tmeff1 and Tas1r2	1	0.16	0.25	0.13	0.26
100	INT189199	JUN Positive_regulation of KRT16	1	0.31	0.58	0.22	0.26
101	INT251152	Dlg2 Positive_regulation of Localization of Grin2b	1	0.43	0.6	0.92	0.26
102	INT304340	FKBP5 Regulation of NR3C1	1	0.05	0.71	0.37	0.26
103	INT283714	Positive_regulation of Binding of Id2 and Homer1	1	0.08	1.34	0.42	0.26
104	INT283713	Binding of Id2 and Homer1	1	0.06	1.34	0.42	0.26
105	INT242164	Wnt2 Positive_regulation of Localization of Apc	1	0.13	1.53	0.32	0.26
106	INT10277	Il1b Positive_regulation of Transcription of Penk	1	0.46	0.26	0.49	0.26
107	INT251153	Dlg2 Positive_regulation of Gene_expression of Grin2a	1	0.40	0.6	0.92	0.26
108	INT103214	Binding of Il1b and Pnoc	1	0.40	0.23	0.61	0.26
109	INT241451	Mag Positive_regulation of Ngfr	1	0.09	0.1	0.21	0.26
110	INT159964	Tnf Positive_regulation of Phosphorylation of Mapk8	1	0.11	0.94	0.29	0.26
111	INT307781	Apoa1 Positive_regulation of LCAT	1	0.76	1.19	0.45	0.26
112	INT308534	Binding of HIVEP1 and Alms1	1	0.00	0.96	0.13	0.26
113	INT307780	Apoa1 Positive_regulation of Soat1	1	0.04	1.14	0.42	0.26
114	INT356199	GOPC Positive_regulation of Acot7	1	0.04	0.33	0.4	0.26
115	INT313993	Ros1 Positive_regulation of Nfkb1	1	0.05	1.61	0.68	0.26
116	INT106505	Binding of Ptgds and Ptgs2	1	0.01	0.93	0.39	0.25
117	INT189196	RASGRP1 Positive_regulation of SP1	1	0.05	0.63	0.21	0.25
118	INT144344	Binding of Npvf and Qrfp	1	0.16	0	0.34	0.25
119	INT144345	Binding of Qrfpr and Qrfp	1	0.40	0	0.34	0.25
120	INT356235	SLC32A1 Regulation of Localization of Gabrg1	1	0.10	1.21	0.7	0.25
121	INT356232	Slc32a1 Regulation of Localization of Gabrg1	1	0.10	1.21	0.7	0.25
122	INT283842	Binding of hb and Insrr	1	0.01	1.35	0.38	0.25
123	INT283840	Binding of Egf and hb	1	0.21	1.34	0.38	0.25
124	INT333764	Il6 Regulation of Gene_expression of Il6ra	1	0.02	0.52	0.12	0.25
125	INT230499	Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1	1	0.01	0.85	0.36	0.25
126	INT282142	Grm1 Positive_regulation of Positive_regulation of Trib3	1	0.01	0.27	0.57	0.24
127	INT250247	FCGR3A Negative_regulation of AQP4	1	0.01	0.87	0.62	0.24
128	INT254637	Bdkrb2 Regulation of Gene_expression of Ccl5	1	0.17	1.22	0.56	0.24
129	INT212139	Slc4a3 Positive_regulation of Cl	1	0.07	0	0.12	0.24
130	INT212138	Slc4a3 Positive_regulation of Gene_expression of Cl	1	0.07	0	0.12	0.24
131	INT237641	Binding of Cntnap1 and Nfasc	2	0.36	0.1	0.29	0.24
132	INT88583	Hal Positive_regulation of Prl	1	0.15	0.44	0.95	0.24
133	INT330464	Setd1a Regulation of Gene_expression of RT1-CE1	1	0.00	0.47	0.35	0.24
134	INT48304	Positive_regulation of MBP Positive_regulation of PLP1	1	0.10	0.97	0.64	0.23
135	INT48303	MBP Positive_regulation of PLP1	1	0.10	0.97	0.64	0.23
136	INT256045	Binding of BDNF and Ntrk1	3	0.34	0.65	0.83	0.23
137	INT237644	Cntn1 Regulation of Cntn1 Positive_regulation of Nfasc	1	0.01	0.22	0.3	0.23
138	INT237647	Nfasc Positive_regulation of Cntn1 Regulation of Nfasc	1	0.07	0.22	0.3	0.23
139	INT237635	Cntn1 Regulation of Nfasc	1	0.04	0.22	0.3	0.23
140	INT237645	Nfasc Regulation of Cntn1 Positive_regulation of Nfasc	1	0.04	0.22	0.3	0.23
141	INT237638	Cntn1 Positive_regulation of Nfasc	1	0.07	0.22	0.3	0.23
142	INT237646	Cntn1 Positive_regulation of Cntn1 Regulation of Nfasc	1	0.01	0.22	0.3	0.23
143	INT324691	Tlr6 Positive_regulation of Rcvrn	1	0.01	0	0.12	0.23
144	INT324695	Tlr6 Positive_regulation of Tlr2	1	0.14	0	0.12	0.23
145	INT333765	Positive_regulation of Vdr Regulation of Gene_expression of Ccr6	1	0.21	0.48	0.12	0.23
146	INT298348	ANGPT2 Positive_regulation of Phosphorylation of Stat3	1	0.18	0.14	0.28	0.23
147	INT126831	Binding of Oprk1 and Rbm39	1	0.05	0.88	1.33	0.23
148	INT242624	Binding of Ngf and Ntrk2	5	0.24	0.48	1.11	0.22
149	INT272984	Il6 Positive_regulation of Gene_expression of Itgam	1	0.24	0.78	0.96	0.22
150	INT271525	ITGB1 Positive_regulation of Gopc	1	0.02	0.57	0.11	0.22
151	INT330462	Ngf Positive_regulation of Gene_expression of Adh1	1	0.01	0.57	0.31	0.22
152	INT265886	IGF1 Positive_regulation of AKT1	1	0.11	3.06	0.23	0.22
153	INT246970	Binding of Clns1a and Dcps	1	0.05	0.42	0.18	0.22
154	INT246968	Binding of Csf2 and Dcps	1	0.14	0.42	0.18	0.22
155	INT346915	Il12a Positive_regulation of Positive_regulation of IFN1@	1	0.20	1.26	0.34	0.22
156	INT236835	Binding of CISH and CSF2	1	0.06	1.43	1.25	0.22
157	INT91700	Il6 Negative_regulation of Oprd1	1	0.23	0	0.7	0.22
158	INT348970	Binding of MOG and HAND1	1	0.03	1.28	0.2	0.22
159	INT187468	Alms1 Positive_regulation of H2-D1	1	0.02	0.32	0.11	0.21
160	INT251145	Binding of Grin2a and Dlg2	1	0.31	2.3	2.11	0.21
161	INT32839	Binding of Trh and Penk	2	0.42	0	1.63	0.21
162	INT32840	Regulation of Binding of Trh and Penk	1	0.26	0	0.91	0.21
163	INT289357	Ngfr Positive_regulation of Akt1	1	0.03	3.1	0.66	0.21
164	INT215564	Hmmr Negative_regulation of P2ry2	1	0.00	0	0.44	0.21
165	INT142076	IL4 Negative_regulation of Gene_expression of IFNG	1	0.01	1.58	0.64	0.21
166	INT40151	Nts Regulation of Trh	1	0.21	0	0.29	0.21
167	INT40152	Sst Regulation of Trh	1	0.22	0	0.29	0.20
168	INT303815	Binding of Igfals and Tdp1	1	0.11	1.68	0.1	0.20
169	INT7927	Penk Regulation of Trh	2	0.26	0.66	1.09	0.20
170	INT61053	Adarb1 Positive_regulation of Pomc Negative_regulation of Odc1	1	0.01	0	1.1	0.20
171	INT288219	Cigs1 Regulation of Nrgn	1	0.00	0.87	0.1	0.20
172	INT72229	Binding of NFKBIL1 and BTRC	1	0.00	0	0.73	0.20
173	INT297543	Neurod1 Regulation of Psen1	1	0.00	0.2	0.12	0.20
174	INT181450	Binding of Ccr5 and Ccl3	4	0.18	2.19	1.03	0.20
175	INT5612	Cck Positive_regulation of Localization of Crh	1	0.65	0.16	1	0.20
176	INT218784	Binding of TCEB2 and VHL	1	0.04	3.81	0.1	0.20
177	INT297548	Neurod1 Regulation of Hes1	1	0.05	0.2	0.1	0.20
178	INT114036	Binding of Grin1 and Psd	1	0.24	0.45	0.68	0.20
179	INT297546	Neurod1 Regulation of Notch1	1	0.05	0.2	0.1	0.20
180	INT314141	Binding of Tacr3 and SFTPA1	1	0.00	3.02	2.48	0.20
181	INT314142	Binding of TAC1 and Tacr3	1	0.06	0.73	0.94	0.20
182	INT54942	Rb1 Regulation of Gab1	1	0.02	0.39	0.59	0.20
183	INT221956	CDK5R1 Regulation of Positive_regulation of CDK5	1	0.21	0.62	0.19	0.20
184	INT198525	Binding of Kif5b and Ranbp2	1	0.23	0	0.1	0.20
185	INT118786	Binding of KIAA0101 and NANS	1	0.28	4.67	0.3	0.19
186	INT137699	AR Regulation of PDYN	1	0.46	0.93	0.75	0.19
187	INT263756	Binding of Bmp1 and Neto1	1	0.30	0.11	0.54	0.19
188	INT263738	Binding of C1ra and Neto1	1	0.42	0.11	0.53	0.19
189	INT251665	LRP5 Negative_regulation of Ache	1	0.31	0.39	0.19	0.19
190	INT221958	CDK5R1 Positive_regulation of Positive_regulation of CDK5	1	0.36	0.38	0.1	0.19
191	INT91305	Binding of Npff and Npffr2	2	0.31	0.64	1.32	0.19
192	INT91306	Binding of Npff and Npffr1	1	0.23	0.17	0.6	0.19
193	INT314136	Binding of TAC1 and SFTPA1	2	0.03	0.78	1.06	0.19
194	INT308749	Gene_expression of C11orf9 Positive_regulation of Gene_expression of MAG	1	0.13	0.08	0.09	0.19
195	INT215096	Binding of Hmgb1 and Tlr2	9	0.38	11.61	1.61	0.19
196	INT185515	Binding of Igf1 and Csf2	1	0.29	0.4	0.15	0.19
197	INT275407	Binding of ERVW-1 and Ccr5	1	0.00	1.74	0.46	0.19
198	INT296446	Binding of Gria2 and Gria4	1	0.13	0.55	0.57	0.19
199	INT308662	Binding of Esr1 and Fdft1	1	0.00	0.05	0.09	0.19
200	INT308666	Binding of Lrp1 and Chol1	1	0.10	0.69	0.09	0.19

Single Events

The table below shows the top 200 pain related interactions that have been reported for central nervous system. They are ordered first by their pain relevance and then by number of times they were reported in central nervous system. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT5200	Gene_expression of Fos	3083	0.78	894.43	1639.02	16.57
2	INT2542	Localization of Calca	2008	0.81	518.3	1408.65	4.36
3	INT796	Gene_expression of Penk	1902	0.78	275.47	1057.59	7.29
4	INT158	Localization of Prl	2431	0.81	378.96	952.2	6.80
5	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	10.06
6	INT7114	Positive_regulation of Ltp	1192	0.62	290.76	755.77	5.12
7	INT1912	Gene_expression of Calca	1152	0.78	453.25	739.84	1.08
8	INT3439	Localization of Abat	1017	0.78	112.39	727.06	1.93
9	INT5202	Positive_regulation of Gene_expression of Fos	1163	0.70	319.28	684	5.11
10	INT292	Localization of Penk	876	0.81	88.44	669.14	4.71
11	INT58061	Gene_expression of Trpv1	1117	0.78	451.54	637.59	3.92
12	INT728	Positive_regulation of Penk	1068	0.70	186.9	636.87	3.51
13	INT2543	Positive_regulation of Calca	787	0.70	331.13	592.08	0.37
14	INT797	Regulation of Penk	812	0.62	111.13	542.24	3.56
15	INT5228	Positive_regulation of Fos	934	0.70	209.8	503.87	2.41
16	INT155	Positive_regulation of Prl	1233	0.70	317.93	457.82	62.42
17	INT1045	Localization of LH	1211	0.81	87.04	456.25	1.56
18	INT443	Localization of POMC	1020	0.81	284.52	443.17	5.01
19	INT50058	Negative_regulation of Cpox	907	0.58	426.28	428.29	2.30
20	INT9238	Gene_expression of IL6	1575	0.78	1135.66	424.22	2.91
21	INT4758	Positive_regulation of Localization of Calca	557	0.70	138.55	411.04	0.13
22	INT5895	Gene_expression of Oprm1	525	0.78	120.67	407.29	4.21
23	INT64202	Positive_regulation of Trpv1	643	0.70	249.66	397.42	2.05
24	INT467	Gene_expression of POMC	1048	0.78	332.8	394.16	4.92
25	INT1395	Negative_regulation of Penk	537	0.59	87.33	389.81	1.65
26	INT6056	Negative_regulation of Gene_expression of Fos	601	0.59	193.05	386.84	3.13
27	INT76660	Gene_expression of Trpv1	691	0.78	329.46	386.42	1.73
28	INT2540	Negative_regulation of Calca	538	0.59	172.11	384.38	0.65
29	INT18357	Gene_expression of TRPV1	825	0.78	307.11	382.81	2.45
30	INT6580	Negative_regulation of Ptgs1	929	0.59	381.53	376.26	0.79
31	INT157	Positive_regulation of Localization of Prl	790	0.70	104.54	374.78	75.04
32	INT287	Localization of Cck	518	0.81	86.84	364.04	1.99
33	INT439	Localization of Gnrh1	976	0.81	100.96	363.25	3.05
34	INT720	Positive_regulation of POMC	807	0.70	237.37	353.83	2.90
35	INT5660	Binding of Oprd1	477	0.48	71.86	342.06	1.47
36	INT876	Localization of Gh1	843	0.80	67.75	340.82	3.19
37	INT16260	Gene_expression of Bdnf	671	0.78	283.44	339.1	4.93
38	INT5235	Negative_regulation of TNF	924	0.59	772.91	331.98	3.04
39	INT2649	Regulation of Calca	433	0.62	146.05	330.95	1.93
40	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81	2.92
41	INT162	Regulation of Prl	794	0.62	165.01	322.24	1.58
42	INT5979	Gene_expression of Oprd1	428	0.78	75.64	320.32	2.01
43	INT34869	Negative_regulation of PTGS2	778	0.59	366.76	319.85	1.18
44	INT5540	Positive_regulation of Oprm1	344	0.70	76.77	319.71	1.90
45	INT5680	Gene_expression of Ngf	530	0.78	264.29	310.56	1.71
46	INT46460	Gene_expression of NAV1	288	0.78	135.51	305.75	4.22
47	INT4941	Positive_regulation of Oprd1	345	0.70	74.26	304.41	1.03
48	INT9131	Positive_regulation of Prkcg	431	0.70	130.8	302.41	1.02
49	INT477	Localization of Avp	813	0.81	131.58	300.4	1.02
50	INT161	Regulation of Localization of Prl	615	0.62	65.37	298.66	1.58
51	INT63932	Positive_regulation of Ephb1	537	0.70	259.67	296.14	1.78
52	INT1352	Localization of Acot1	728	0.80	73.01	296.01	1.26
53	INT886	Gene_expression of Pomc	676	0.78	129.87	295.98	1.64
54	INT11624	Gene_expression of OPRM1	445	0.78	72.36	294.36	0.73
55	INT5379	Gene_expression of Fos	656	0.78	255.5	292.54	3.46
56	INT3579	Localization of Oxt	555	0.81	43.35	292.44	2.19
57	INT97367	Gene_expression of Nav1	243	0.78	132.97	286.66	2.37
58	INT9158	Gene_expression of Tnf	722	0.78	522.01	277.68	2.54
59	INT2365	Positive_regulation of Cck	354	0.70	87.8	277.41	1.03
60	INT9381	Positive_regulation of TRPV1	523	0.70	187.4	276.05	1.42
61	INT94450	Gene_expression of Nav1	359	0.78	131.85	275.46	0.82
62	INT49750	Negative_regulation of CPOX	735	0.58	360.06	274.19	0.50
63	INT6852	Localization of TNF	883	0.81	705.95	270.84	3.19
64	INT10832	Gene_expression of IL8	1050	0.78	698.72	270	0.44
65	INT1396	Binding of Penk	355	0.48	22.79	269.65	1.24
66	INT5591	Regulation of Gene_expression of Fos	425	0.62	129.06	265.78	2.29
67	INT9659	Gene_expression of Il6	991	0.78	715.11	265.57	3.96
68	INT5972	Gene_expression of IL1B	948	0.78	510.91	263.97	1.10
69	INT68684	Gene_expression of VEGFA	2371	0.78	1742.52	259.2	1.99
70	INT87687	Positive_regulation of Trpv1	409	0.70	210.24	257.59	0.24
71	INT1893	Localization of Gh	1041	0.79	340.23	256.58	1.94
72	INT16868	Gene_expression of Il6	807	0.78	499.48	256.57	1.94
73	INT2909	Positive_regulation of Abat	334	0.70	62.1	256.43	1.35
74	INT3948	Regulation of Cck	291	0.62	58.07	255.88	0.91
75	INT5501	Regulation of Oprd1	283	0.62	55.1	249.9	1.98
76	INT1005	Localization of Sst	385	0.81	26.31	244.56	0.63
77	INT738	Regulation of POMC	459	0.62	111.19	243.74	1.50
78	INT1902	Gene_expression of Cck	348	0.78	70.33	241.92	1.30
79	INT11377	Positive_regulation of Ngf	331	0.70	206.5	238	1.15
80	INT1562	Localization of Crh	499	0.81	126.74	236.68	3.73
81	INT5597	Gene_expression of Pdyn	433	0.78	62.97	235.47	2.76
82	INT1665	Positive_regulation of Pag1	270	0.68	186.63	229.87	0.38
83	INT4759	Negative_regulation of Localization of Calca	294	0.59	82.62	226.45	0.24
84	INT9987	Gene_expression of Abat	296	0.78	95.46	226.34	1.76
85	INT6406	Binding of Oprm1	280	0.48	40.54	226.26	1.05
86	INT1212	Binding of Oprl1	312	0.48	28.6	225.15	3.82
87	INT11009	Phosphorylation of Creb1	458	0.82	111.34	221.97	1.85
88	INT626	Localization of CALCA	289	0.81	125.39	221.15	1.53
89	INT95787	Positive_regulation of Mapk1	568	0.70	226.51	220.94	0.71
90	INT6665	Gene_expression of FOS	520	0.77	165.31	217.66	1.35
91	INT1308	Localization of Pomc	457	0.81	66.83	217.5	1.51
92	INT6293	Gene_expression of Oprm1	312	0.78	48.73	215.61	2.03
93	INT6481	Binding of TNF	624	0.48	510.2	214.82	0.85
94	INT767	Localization of Gnrhr	565	0.80	106.68	214.57	2.29
95	INT4893	Gene_expression of Tacr1	366	0.78	129.67	213.92	2.60
96	INT22548	Positive_regulation of Casp3	483	0.70	258.78	213.07	1.12
97	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210	2.45
98	INT16259	Positive_regulation of Bdnf	336	0.70	183.48	209.82	2.38
99	INT48955	Gene_expression of Nos2	753	0.78	403.87	208.08	3.25
100	INT2651	Positive_regulation of Pomc	403	0.70	95.72	206.24	1.60
101	INT2391	Negative_regulation of PTGS1	501	0.59	207.62	205.6	0.76
102	INT9132	Negative_regulation of Prkcg	279	0.59	88.05	203.47	0.77
103	INT798	Positive_regulation of Gene_expression of Penk	394	0.70	78.53	203.07	1.76
104	INT11313	Positive_regulation of Il6	526	0.70	331.27	201.59	2.64
105	INT2211	Negative_regulation of Abat	267	0.59	66.51	200.98	0.71
106	INT50670	Gene_expression of CPOX	763	0.76	442.13	195.02	1.71
107	INT156	Negative_regulation of Prl	542	0.59	131.97	192.24	10.34
108	INT528	Gene_expression of Prl	693	0.78	217.18	192.2	0.47
109	INT6488	Gene_expression of Tnf	484	0.78	339.61	191.58	2.52
110	INT2085	Positive_regulation of LH	441	0.70	60.15	191.02	0.33
111	INT63934	Phosphorylation of Ephb1	377	0.82	150.52	188.66	1.62
112	INT6354	Localization of Gabrg1	321	0.74	41.41	186.74	1.24
113	INT94952	Positive_regulation of Mapk14	305	0.70	197.83	186.61	4.95
114	INT1652	Regulation of Pomc	387	0.62	61.01	186.51	1.64
115	INT24326	Gene_expression of Ngf	346	0.78	218.67	184.71	2.41
116	INT10194	Positive_regulation of IL6	702	0.70	600.62	183.38	3.25
117	INT4803	Transcription of Penk	435	0.72	59.09	182.4	1.08
118	INT3440	Negative_regulation of Localization of Abat	221	0.57	33.94	180.36	0.30
119	INT12602	Negative_regulation of Oprm1	190	0.59	36.11	177.85	0.64
120	INT49441	Negative_regulation of Cpox	494	0.59	303.22	177.46	2.32
121	INT7506	Negative_regulation of Ltp	267	0.46	91.01	176.8	0.58
122	INT1429	Gene_expression of PDYN	308	0.78	61.33	175.65	2.51
123	INT19472	Gene_expression of Il1	554	0.76	419.75	175.35	10.96
124	INT943	Negative_regulation of Cck	205	0.59	38.42	174.78	0.59
125	INT26472	Regulation of Oprm1	191	0.62	35.84	173.1	0.49
126	INT5930	Positive_regulation of Oprm1	221	0.70	31.19	172.93	0.72
127	INT159	Negative_regulation of Localization of Prl	416	0.59	55.34	171.8	1.21
128	INT4937	Negative_regulation of Oprd1	224	0.59	44.51	171.11	0.92
129	INT438	Gene_expression of Crh	376	0.78	159.11	169.17	0.64
130	INT867	Gene_expression of IFNA1	930	0.78	594.85	168.03	2.70
131	INT739	Negative_regulation of POMC	358	0.59	102.28	166.77	0.63
132	INT55879	Gene_expression of CCL2	421	0.78	240.74	166.02	3.20
133	INT1114	Localization of Ins1	748	0.80	192.95	165.48	5.18
134	INT4768	Positive_regulation of OPRM1	212	0.70	31.09	164.28	0.08
135	INT2366	Binding of Cck	192	0.48	30.64	163.46	1.87
136	INT5127	Localization of Lhb	488	0.80	50.48	162.66	1.11
137	INT3448	Positive_regulation of Gh	521	0.69	180.03	161.18	0.49
138	INT5513	Negative_regulation of Pomc	295	0.59	60.9	158.63	1.16
139	INT51921	Gene_expression of Cpox	501	0.73	229.81	157.81	2.25
140	INT21185	Binding of Ptprg	213	0.47	13.49	157.75	0.80
141	INT66280	Gene_expression of Nos2	534	0.78	330.78	157.07	3.73
142	INT768	Positive_regulation of Oprl1	179	0.70	40.05	156.93	0.59
143	INT1303	Negative_regulation of Npr1	278	0.55	35.1	156.78	0.35
144	INT2640	Gene_expression of Pomc	424	0.78	120.72	155.37	4.26
145	INT6042	Binding of Oprm1	248	0.48	31.77	154.34	1.36
146	INT4740	Gene_expression of Th	298	0.78	61.27	154.03	0.52
147	INT2910	Regulation of Abat	169	0.62	36.95	153.53	0.54
148	INT1044	Negative_regulation of Localization of LH	358	0.59	25.95	151.31	0.36
149	INT120811	Gene_expression of Gopc	1174	0.59	428.49	150.55	2.72
150	INT4829	Positive_regulation of Localization of Abat	199	0.55	20.91	150.48	0.09
151	INT880	Positive_regulation of Localization of Gh1	304	0.70	14.79	150.23	0.38
152	INT49134	Gene_expression of Grin1	270	0.78	84.78	148.61	1.06
153	INT5050	Regulation of Localization of Calca	149	0.62	41.25	148.57	0.06
154	INT6108	Gene_expression of Npy	292	0.78	110.65	148.21	1.38
155	INT13353	Positive_regulation of Tnf	332	0.70	248.75	148.1	2.02
156	INT7628	Gene_expression of Ltp	273	0.77	70.21	147.87	1.60
157	INT2451	Positive_regulation of Avp	355	0.70	102.66	147.69	0.15
158	INT1033	Positive_regulation of Ca2	507	0.68	131.76	147.64	1.28
159	INT9852	Positive_regulation of Gpt	563	0.70	364.64	146.82	0.08
160	INT5116	Gene_expression of IL2	670	0.78	291.13	146.69	1.08
161	INT812	Localization of INS	1026	0.81	515.6	145.31	0.71
162	INT425	Localization of PRL	455	0.81	189.64	144.8	1.41
163	INT2379	Positive_regulation of Localization of LH	349	0.70	27.86	144.53	0.29
164	INT3300	Positive_regulation of Gene_expression of Calca	179	0.70	77.76	144.2	0.19
165	INT2780	Regulation of Gene_expression of Penk	265	0.62	32.45	143.88	0.25
166	INT60694	Gene_expression of Il10	567	0.78	369.48	143.69	3.56
167	INT9660	Regulation of TNF	363	0.62	312.94	139.99	0.65
168	INT1414	Regulation of Oprl1	169	0.62	32.05	139.99	0.94
169	INT90910	Phosphorylation of Grin1	150	0.82	68.23	139.24	0.31
170	INT14843	Gene_expression of Gabrg1	301	0.77	62.63	139.16	1.68
171	INT1273	Gene_expression of Avp	356	0.78	90.56	138.7	2.01
172	INT48895	Gene_expression of Il10	333	0.78	221.2	138.52	0.97
173	INT2867	Gene_expression of CALCA	247	0.78	78.78	138.47	0.66
174	INT5061	Negative_regulation of Mme	306	0.59	51.97	136.9	0.82
175	INT4658	Binding of OPRM1	188	0.48	25.96	136.24	0.64
176	INT1047	Negative_regulation of LH	314	0.59	53.71	135.89	1.31
177	INT2541	Binding of Calca	200	0.48	67.14	134.62	0.58
178	INT60126	Regulation of Trpv1	186	0.62	85.53	133.4	0.49
179	INT11012	Positive_regulation of Creb1	258	0.70	84.4	132	1.27
180	INT48953	Positive_regulation of Nos2	486	0.70	239.85	131.87	1.37
181	INT5497	Positive_regulation of Crh	299	0.70	125.54	131.14	1.23
182	INT5380	Positive_regulation of Gene_expression of Fos	243	0.70	105.65	131.05	1.44
183	INT49439	Gene_expression of Cpox	508	0.73	326.97	130.17	2.44
184	INT5595	Positive_regulation of Pdyn	223	0.70	48.37	130.14	0.35
185	INT64161	Positive_regulation of Prkca	213	0.70	85.06	129.91	0.42
186	INT115386	Gene_expression of Ppara	779	0.77	549.99	128.36	5.89
187	INT65600	Positive_regulation of Casp3	376	0.70	198.44	128.03	1.90
188	INT1614	Gene_expression of Oprl1	164	0.78	31.43	127.74	2.78
189	INT5842	Gene_expression of Gfap	372	0.78	153.71	127.71	2.05
190	INT1878	Binding of HLA-B	440	0.48	321.16	127.36	0.08
191	INT695	Binding of POMC	304	0.48	56.66	126.85	0.85
192	INT65054	Positive_regulation of Nfkb1	285	0.70	149.33	126.73	1.11
193	INT5931	Regulation of Oprm1	149	0.62	18.15	125.93	1.07
194	INT6822	Gene_expression of Pdyn	215	0.78	35.99	125.76	0.10
195	INT416	Regulation of LH	253	0.62	31.48	125.55	0.45
196	INT5008	Localization of Calca	204	0.81	80.35	125.16	0.40
197	INT6323	Positive_regulation of Gabrg1	213	0.70	45.08	124.34	1.63
198	INT4824	Positive_regulation of Tacr1	169	0.70	66.1	123.46	0.67
199	INT4259	Positive_regulation of Npr1	262	0.70	49.37	123.11	0.33
200	INT2106	Regulation of Localization of LH	279	0.62	22.37	122.77	0.70