P:central nervous system

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Pain Term
Category Anatomy
Synonyms None
Pain Specific No
Documents 11898
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for central nervous system. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27 100.00
2 INT181453 Gene_expression of Ccl2 Positive_regulation of Gene_expression of Il12rb1 1 0.06 1.87 0.34 100.00
3 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49 100.00
4 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96 100.00
5 INT235956 Binding of Aqp4 and NMO-IgG 1 0.04 4.53 0.5 100.00
6 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 100.00
7 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3 100.00
8 INT237633 Cntn1 Regulation of Gene_expression of Ank3 1 0.00 0.23 0.33 100.00
9 INT237637 Cntn1 Positive_regulation of Gene_expression of Ank3 1 0.00 0.23 0.33 100.00
10 INT237640 Nfasc Regulation of Gene_expression of Ank3 1 0.01 0.23 0.32 100.00
11 INT237634 Nfasc Positive_regulation of Gene_expression of Ank3 1 0.02 0.23 0.32 100.00
12 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45 100.00
13 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42 100.00
14 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11 100.00
15 INT61053 Adarb1 Positive_regulation of Pomc Negative_regulation of Odc1 1 0.01 0 1.1 100.00
16 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 100.00
17 INT355984 PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 100.00
18 INT355979 Negative_regulation of PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 100.00
19 INT61051 Pomc Negative_regulation of Odc1 1 0.22 0 0.54 100.00
20 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37 100.00
21 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37 100.00
22 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28 100.00
23 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28 100.00
24 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 100.00
25 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 100.00
26 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 100.00
27 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17 99.96
28 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26 99.86
29 INT273045 Vip Regulation of Adcyap1 1 0.17 0.5 0.38 99.84
30 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23 99.84
31 INT251161 Binding of Trpv1 and Rxfp2 1 0.06 0.18 0.55 99.84
32 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 99.72
33 INT3571 Sst Regulation of Negative_regulation of Gh1 1 0.24 0 0.42 99.68
34 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33 99.68
35 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56 99.68
36 INT3433 Vip Positive_regulation of Positive_regulation of Oprl1 1 0.26 0 0.53 99.68
37 INT235963 Snta1 Regulation of Gene_expression of Aqp4 1 0.41 0.23 0.05 99.68
38 INT237644 Cntn1 Regulation of Cntn1 Positive_regulation of Nfasc 1 0.01 0.22 0.3 99.66
39 INT237647 Nfasc Positive_regulation of Cntn1 Regulation of Nfasc 1 0.07 0.22 0.3 99.66
40 INT237635 Cntn1 Regulation of Nfasc 1 0.04 0.22 0.3 99.66
41 INT237645 Nfasc Regulation of Cntn1 Positive_regulation of Nfasc 1 0.04 0.22 0.3 99.66
42 INT237638 Cntn1 Positive_regulation of Nfasc 1 0.07 0.22 0.3 99.66
43 INT237646 Cntn1 Positive_regulation of Cntn1 Regulation of Nfasc 1 0.01 0.22 0.3 99.66
44 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93 99.62
45 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32 99.60
46 INT91306 Binding of Npff and Npffr1 1 0.23 0.17 0.6 99.60
47 INT283842 Binding of hb and Insrr 1 0.01 1.35 0.38 99.52
48 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1 99.52
49 INT67440 Pdyn Regulation of Gene_expression of Tnf 1 0.23 0.19 0.48 99.48
50 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42 99.44
51 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13 99.44
52 INT137699 AR Regulation of PDYN 1 0.46 0.93 0.75 99.40
53 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 99.34
54 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 99.28
55 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01 99.28
56 INT256586 Binding of RBP4 and TTR 1 0.07 1.92 0.18 99.24
57 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 99.20
58 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38 99.16
59 INT114036 Binding of Grin1 and Psd 1 0.24 0.45 0.68 99.16
60 INT298348 ANGPT2 Positive_regulation of Phosphorylation of Stat3 1 0.18 0.14 0.28 99.08
61 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 99.04
62 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25 99.04
63 INT33752 Apoa2 Regulation of Localization of POMC 1 0.06 0 0.12 99.00
64 INT310547 Binding of TCN1 and ERLIN1 1 0.00 0.17 0.05 99.00
65 INT250253 Binding of AQP4 and SLC1A2 1 0.30 2.95 1.09 98.96
66 INT250252 Binding of SLC1A2 and GOPC 1 0.05 0.44 0.35 98.96
67 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 98.96
68 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 98.88
69 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 98.88
70 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09 98.88
71 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 98.84
72 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05 98.84
73 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18 98.72
74 INT250248 Binding of AQP4 and SLC1A3 1 0.11 1.55 0.77 98.66
75 INT250254 Binding of SLC1A3 and GOPC 1 0.02 0.44 0.35 98.66
76 INT206535 Binding of Trem2 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.5 0.27 98.64
77 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69 98.58
78 INT296446 Binding of Gria2 and Gria4 1 0.13 0.55 0.57 98.56
79 INT198525 Binding of Kif5b and Ranbp2 1 0.23 0 0.1 98.48
80 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1 98.48
81 INT188745 AGRP Regulation of Gene_expression of CSF2 1 0.07 1.48 0.08 98.48
82 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01 98.44
83 INT121081 Negative_regulation of NOS1 Negative_regulation of Slep1 1 0.00 0 0.52 98.44
84 INT214033 OGG1 Negative_regulation of BPIFA4P 1 0.08 0.71 0.05 98.36
85 INT250242 Binding of AQP4 and GOPC 1 0.06 0.39 0.35 98.34
86 INT33750 Apoa2 Regulation of Agt 1 0.07 0 0.12 98.32
87 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43 98.24
88 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11 98.24
89 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59 98.24
90 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31 98.24
91 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37 98.08
92 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37 98.08
93 INT246692 Zglp1 Regulation of Gene_expression of Ros1 1 0.04 0.38 0.24 98.08
94 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 97.92
95 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12 97.84
96 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 97.80
97 INT121830 Binding of Scgb1d2 and Lnp 1 0.02 0.33 0.26 97.78
98 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07 97.68
99 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54 97.68
100 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19 97.68
101 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43 97.68
102 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96 97.68
103 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45 97.68
104 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1 97.64
105 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1 97.60
106 INT326404 Binding of Cck and Enpep 1 0.01 0.19 0.23 97.60
107 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 97.56
108 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34 97.56
109 INT287096 Binding of Bdnf and FL 1 0.16 1.15 0.6 97.56
110 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24 97.56
111 INT5614 Cck Regulation of Localization of Pomc 1 0.12 0.08 0.62 97.52
112 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 97.48
113 INT308749 Gene_expression of C11orf9 Positive_regulation of Gene_expression of MAG 1 0.13 0.08 0.09 97.40
114 INT32755 Binding of Gabrg1 and Abat 1 0.10 0 0.59 97.40
115 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83 97.28
116 INT3434 Vip Positive_regulation of Localization of Prl 6 0.76 0.16 3.21 97.28
117 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05 97.28
118 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 97.24
119 INT348403 FDPS Negative_regulation of FDPS Negative_regulation of Fdps 1 0.03 0.79 0.71 97.24
120 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2 97.04
121 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 97.00
122 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85 97.00
123 INT201740 Positive_regulation of Ngf Positive_regulation of Nfkb1 1 0.01 1.07 0.51 97.00
124 INT201727 Ngf Positive_regulation of Nfkb1 1 0.01 1 0.48 97.00
125 INT263756 Binding of Bmp1 and Neto1 1 0.30 0.11 0.54 96.96
126 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53 96.96
127 INT250251 Binding of SLC1A2 and SLC1A3 1 0.09 1.12 0.43 96.88
128 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55 96.88
129 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24 96.88
130 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 96.76
131 INT333765 Positive_regulation of Vdr Regulation of Gene_expression of Ccr6 1 0.21 0.48 0.12 96.68
132 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1 96.68
133 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45 96.68
134 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3 96.68
135 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5 96.64
136 INT188746 Binding of CSF2 and HIVEP1 1 0.04 3.99 0.21 96.64
137 INT333761 Il27 Positive_regulation of Il10 1 0.16 0.58 0.13 96.64
138 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72 96.56
139 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46 96.56
140 INT254636 Bdkrb2 Regulation of Gene_expression of Ccl2 1 0.15 1.15 0.43 96.52
141 INT239572 DPF1 Positive_regulation of AIS 1 0.02 0.71 0.24 96.52
142 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55 96.44
143 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54 96.44
144 INT33985 Binding of Tmeff1 and Tas1r2 1 0.16 0.25 0.13 96.40
145 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2 96.36
146 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58 96.08
147 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48 96.00
148 INT72029 Binding of ADM and IAPP 1 0.12 0.26 0.13 96.00
149 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17 95.76
150 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46 95.76
151 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77 95.76
152 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77 95.76
153 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1 95.76
154 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1 95.76
155 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1 95.76
156 INT294692 LPA Positive_regulation of BATF 1 0.00 0 0.09 95.76
157 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77 95.72
158 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77 95.72
159 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55 95.52
160 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88 95.48
161 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 95.44
162 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42 95.44
163 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16 95.40
164 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36 95.28
165 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77 95.12
166 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97 95.12
167 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46 95.12
168 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 95.12
169 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 95.12
170 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93 95.12
171 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22 95.04
172 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2 95.00
173 INT327182 Binding of Mpl and Thpo 1 0.41 0.54 0.37 94.96
174 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07 94.88
175 INT298350 HES3 Positive_regulation of HES3 Positive_regulation of Shh 1 0.09 0.14 0.07 94.88
176 INT10277 Il1b Positive_regulation of Transcription of Penk 1 0.46 0.26 0.49 94.72
177 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52 94.64
178 INT141072 GPRASP1 Positive_regulation of Negative_regulation of CNR1 1 0.56 0.09 0.54 94.64
179 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 94.52
180 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05 94.52
181 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13 94.52
182 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17 94.48
183 INT187468 Alms1 Positive_regulation of H2-D1 1 0.02 0.32 0.11 94.44
184 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15 94.40
185 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15 94.32
186 INT12987 LIF Regulation of Localization of Prl 1 0.09 0 0.07 94.28
187 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 94.24
188 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71 94.16
189 INT275386 Binding of Cxcr4 and Htatsf1 1 0.01 3.25 0.97 94.16
190 INT275399 Binding of ERVW-1 and Cxcr4 1 0.00 1.73 0.46 94.16
191 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14 94.12
192 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17 94.00
193 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33 93.96
194 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08 93.88
195 INT72264 Binding of Hrh1 and Hrh3 1 0.11 0.16 0.34 93.80
196 INT330464 Setd1a Regulation of Gene_expression of RT1-CE1 1 0.00 0.47 0.35 93.76
197 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 93.68
198 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 93.68
199 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 93.68
200 INT46308 Asrgl1 Positive_regulation of Gene_expression of Serpinc1 1 0.01 1.07 0.19 93.60

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for central nervous system. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27 100.00
2 INT181453 Gene_expression of Ccl2 Positive_regulation of Gene_expression of Il12rb1 1 0.06 1.87 0.34 100.00
3 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49 100.00
4 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96 100.00
5 INT235956 Binding of Aqp4 and NMO-IgG 1 0.04 4.53 0.5 100.00
6 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 100.00
7 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3 100.00
8 INT237633 Cntn1 Regulation of Gene_expression of Ank3 1 0.00 0.23 0.33 100.00
9 INT237637 Cntn1 Positive_regulation of Gene_expression of Ank3 1 0.00 0.23 0.33 100.00
10 INT237640 Nfasc Regulation of Gene_expression of Ank3 1 0.01 0.23 0.32 100.00
11 INT237634 Nfasc Positive_regulation of Gene_expression of Ank3 1 0.02 0.23 0.32 100.00
12 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45 100.00
13 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42 100.00
14 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11 100.00
15 INT61053 Adarb1 Positive_regulation of Pomc Negative_regulation of Odc1 1 0.01 0 1.1 100.00
16 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 100.00
17 INT355984 PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 100.00
18 INT355979 Negative_regulation of PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 100.00
19 INT61051 Pomc Negative_regulation of Odc1 1 0.22 0 0.54 100.00
20 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37 100.00
21 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37 100.00
22 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28 100.00
23 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28 100.00
24 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 100.00
25 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 100.00
26 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 100.00
27 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17 99.96
28 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26 99.86
29 INT273045 Vip Regulation of Adcyap1 1 0.17 0.5 0.38 99.84
30 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23 99.84
31 INT251161 Binding of Trpv1 and Rxfp2 1 0.06 0.18 0.55 99.84
32 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 99.72
33 INT3571 Sst Regulation of Negative_regulation of Gh1 1 0.24 0 0.42 99.68
34 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33 99.68
35 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56 99.68
36 INT3433 Vip Positive_regulation of Positive_regulation of Oprl1 1 0.26 0 0.53 99.68
37 INT235963 Snta1 Regulation of Gene_expression of Aqp4 1 0.41 0.23 0.05 99.68
38 INT237644 Cntn1 Regulation of Cntn1 Positive_regulation of Nfasc 1 0.01 0.22 0.3 99.66
39 INT237647 Nfasc Positive_regulation of Cntn1 Regulation of Nfasc 1 0.07 0.22 0.3 99.66
40 INT237635 Cntn1 Regulation of Nfasc 1 0.04 0.22 0.3 99.66
41 INT237645 Nfasc Regulation of Cntn1 Positive_regulation of Nfasc 1 0.04 0.22 0.3 99.66
42 INT237638 Cntn1 Positive_regulation of Nfasc 1 0.07 0.22 0.3 99.66
43 INT237646 Cntn1 Positive_regulation of Cntn1 Regulation of Nfasc 1 0.01 0.22 0.3 99.66
44 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93 99.62
45 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32 99.60
46 INT91306 Binding of Npff and Npffr1 1 0.23 0.17 0.6 99.60
47 INT283842 Binding of hb and Insrr 1 0.01 1.35 0.38 99.52
48 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1 99.52
49 INT67440 Pdyn Regulation of Gene_expression of Tnf 1 0.23 0.19 0.48 99.48
50 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42 99.44
51 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13 99.44
52 INT137699 AR Regulation of PDYN 1 0.46 0.93 0.75 99.40
53 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 99.34
54 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 99.28
55 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01 99.28
56 INT256586 Binding of RBP4 and TTR 1 0.07 1.92 0.18 99.24
57 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 99.20
58 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38 99.16
59 INT114036 Binding of Grin1 and Psd 1 0.24 0.45 0.68 99.16
60 INT298348 ANGPT2 Positive_regulation of Phosphorylation of Stat3 1 0.18 0.14 0.28 99.08
61 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 99.04
62 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25 99.04
63 INT33752 Apoa2 Regulation of Localization of POMC 1 0.06 0 0.12 99.00
64 INT310547 Binding of TCN1 and ERLIN1 1 0.00 0.17 0.05 99.00
65 INT250253 Binding of AQP4 and SLC1A2 1 0.30 2.95 1.09 98.96
66 INT250252 Binding of SLC1A2 and GOPC 1 0.05 0.44 0.35 98.96
67 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 98.96
68 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 98.88
69 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 98.88
70 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09 98.88
71 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 98.84
72 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05 98.84
73 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18 98.72
74 INT250248 Binding of AQP4 and SLC1A3 1 0.11 1.55 0.77 98.66
75 INT250254 Binding of SLC1A3 and GOPC 1 0.02 0.44 0.35 98.66
76 INT206535 Binding of Trem2 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.5 0.27 98.64
77 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69 98.58
78 INT296446 Binding of Gria2 and Gria4 1 0.13 0.55 0.57 98.56
79 INT198525 Binding of Kif5b and Ranbp2 1 0.23 0 0.1 98.48
80 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1 98.48
81 INT188745 AGRP Regulation of Gene_expression of CSF2 1 0.07 1.48 0.08 98.48
82 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01 98.44
83 INT121081 Negative_regulation of NOS1 Negative_regulation of Slep1 1 0.00 0 0.52 98.44
84 INT214033 OGG1 Negative_regulation of BPIFA4P 1 0.08 0.71 0.05 98.36
85 INT250242 Binding of AQP4 and GOPC 1 0.06 0.39 0.35 98.34
86 INT33750 Apoa2 Regulation of Agt 1 0.07 0 0.12 98.32
87 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43 98.24
88 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11 98.24
89 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59 98.24
90 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31 98.24
91 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37 98.08
92 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37 98.08
93 INT246692 Zglp1 Regulation of Gene_expression of Ros1 1 0.04 0.38 0.24 98.08
94 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 97.92
95 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12 97.84
96 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 97.80
97 INT121830 Binding of Scgb1d2 and Lnp 1 0.02 0.33 0.26 97.78
98 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07 97.68
99 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54 97.68
100 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19 97.68
101 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43 97.68
102 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96 97.68
103 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45 97.68
104 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1 97.64
105 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1 97.60
106 INT326404 Binding of Cck and Enpep 1 0.01 0.19 0.23 97.60
107 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 97.56
108 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34 97.56
109 INT287096 Binding of Bdnf and FL 1 0.16 1.15 0.6 97.56
110 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24 97.56
111 INT5614 Cck Regulation of Localization of Pomc 1 0.12 0.08 0.62 97.52
112 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 97.48
113 INT308749 Gene_expression of C11orf9 Positive_regulation of Gene_expression of MAG 1 0.13 0.08 0.09 97.40
114 INT32755 Binding of Gabrg1 and Abat 1 0.10 0 0.59 97.40
115 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83 97.28
116 INT3434 Vip Positive_regulation of Localization of Prl 6 0.76 0.16 3.21 97.28
117 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05 97.28
118 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 97.24
119 INT348403 FDPS Negative_regulation of FDPS Negative_regulation of Fdps 1 0.03 0.79 0.71 97.24
120 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2 97.04
121 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 97.00
122 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85 97.00
123 INT201740 Positive_regulation of Ngf Positive_regulation of Nfkb1 1 0.01 1.07 0.51 97.00
124 INT201727 Ngf Positive_regulation of Nfkb1 1 0.01 1 0.48 97.00
125 INT263756 Binding of Bmp1 and Neto1 1 0.30 0.11 0.54 96.96
126 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53 96.96
127 INT250251 Binding of SLC1A2 and SLC1A3 1 0.09 1.12 0.43 96.88
128 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55 96.88
129 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24 96.88
130 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 96.76
131 INT333765 Positive_regulation of Vdr Regulation of Gene_expression of Ccr6 1 0.21 0.48 0.12 96.68
132 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1 96.68
133 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45 96.68
134 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3 96.68
135 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5 96.64
136 INT188746 Binding of CSF2 and HIVEP1 1 0.04 3.99 0.21 96.64
137 INT333761 Il27 Positive_regulation of Il10 1 0.16 0.58 0.13 96.64
138 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72 96.56
139 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46 96.56
140 INT254636 Bdkrb2 Regulation of Gene_expression of Ccl2 1 0.15 1.15 0.43 96.52
141 INT239572 DPF1 Positive_regulation of AIS 1 0.02 0.71 0.24 96.52
142 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55 96.44
143 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54 96.44
144 INT33985 Binding of Tmeff1 and Tas1r2 1 0.16 0.25 0.13 96.40
145 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2 96.36
146 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58 96.08
147 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48 96.00
148 INT72029 Binding of ADM and IAPP 1 0.12 0.26 0.13 96.00
149 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17 95.76
150 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46 95.76
151 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77 95.76
152 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77 95.76
153 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1 95.76
154 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1 95.76
155 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1 95.76
156 INT294692 LPA Positive_regulation of BATF 1 0.00 0 0.09 95.76
157 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77 95.72
158 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77 95.72
159 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55 95.52
160 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88 95.48
161 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 95.44
162 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42 95.44
163 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16 95.40
164 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36 95.28
165 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77 95.12
166 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97 95.12
167 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46 95.12
168 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 95.12
169 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 95.12
170 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93 95.12
171 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22 95.04
172 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2 95.00
173 INT327182 Binding of Mpl and Thpo 1 0.41 0.54 0.37 94.96
174 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07 94.88
175 INT298350 HES3 Positive_regulation of HES3 Positive_regulation of Shh 1 0.09 0.14 0.07 94.88
176 INT10277 Il1b Positive_regulation of Transcription of Penk 1 0.46 0.26 0.49 94.72
177 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52 94.64
178 INT141072 GPRASP1 Positive_regulation of Negative_regulation of CNR1 1 0.56 0.09 0.54 94.64
179 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 94.52
180 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05 94.52
181 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13 94.52
182 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17 94.48
183 INT187468 Alms1 Positive_regulation of H2-D1 1 0.02 0.32 0.11 94.44
184 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15 94.40
185 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15 94.32
186 INT12987 LIF Regulation of Localization of Prl 1 0.09 0 0.07 94.28
187 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 94.24
188 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71 94.16
189 INT275386 Binding of Cxcr4 and Htatsf1 1 0.01 3.25 0.97 94.16
190 INT275399 Binding of ERVW-1 and Cxcr4 1 0.00 1.73 0.46 94.16
191 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14 94.12
192 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17 94.00
193 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33 93.96
194 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08 93.88
195 INT72264 Binding of Hrh1 and Hrh3 1 0.11 0.16 0.34 93.80
196 INT330464 Setd1a Regulation of Gene_expression of RT1-CE1 1 0.00 0.47 0.35 93.76
197 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 93.68
198 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 93.68
199 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 93.68
200 INT46308 Asrgl1 Positive_regulation of Gene_expression of Serpinc1 1 0.01 1.07 0.19 93.60

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