P:dextromethorphan

This page displays the top molecular interactions and top single events that were mentioned in the literature for dextromethorphan. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for dextromethorphan. They are ordered first by their pain relevance and then by number of times they were reported for dextromethorphan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT92370	Binding of CYP2B6 and CYP2D6	1	0.21	0	0.73	94.72
2	INT215290	Siglec1 Negative_regulation of Decr1	1	0.00	0.68	0.41	64.88
3	INT92369	Binding of CYP2D6 and RYBP	1	0.25	0.15	1.73	64.16
4	INT92372	CYP2B6 Positive_regulation of Binding of RYBP	1	0.17	0.09	0.81	26.64
5	INT97208	Binding of Gabrg1 and Gabbr1	2	0.07	0.31	1.94	5.00
6	INT351281	AP1M2 Regulation of NCOR2	1	0.00	0.85	1.9	5.00
7	INT246519	Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp	1	0.25	0.08	1.42	5.00
8	INT262377	Binding of Comt and Fmod	1	0.06	1.47	1.29	5.00
9	INT257895	Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1	1	0.00	0.09	0.83	5.00
10	INT257896	Sostdc1 Positive_regulation of Positive_regulation of GRIN1	1	0.00	0.09	0.83	5.00
11	INT215275	Tlr4 Positive_regulation of Gene_expression of Ros1	1	0.01	1.37	0.38	5.00
12	INT255804	DSP Negative_regulation of Gene_expression of Il6	1	0.01	0.36	0.36	5.00
13	INT255803	Cat Negative_regulation of Gene_expression of Il6	1	0.05	0.35	0.35	5.00
14	INT215274	Tlr4 Positive_regulation of Ros1	2	0.02	1.48	0.28	5.00
15	INT215279	Siglec1 Regulation of Rac2	1	0.01	0.74	0.27	5.00
16	INT215273	Siglec1 Regulation of Ncf2	1	0.01	0.73	0.26	5.00
17	INT215289	Siglec1 Regulation of Cyba	1	0.01	0.74	0.26	5.00
18	INT215280	Siglec1 Regulation of Cybb	1	0.01	0.74	0.26	5.00
19	INT215271	Siglec1 Regulation of Ncf4	1	0.01	0.73	0.26	5.00
20	INT215286	Siglec1 Negative_regulation of Gene_expression of Ros1	1	0.00	2.76	0.25	5.00
21	INT215282	Siglec1 Regulation of Gene_expression of Ros1	1	0.00	0.55	0.18	5.00
22	INT215278	Siglec1 Regulation of Tlr4	1	0.01	0.55	0.18	5.00
23	INT215292	Siglec1 Regulation of Tlr4 Positive_regulation of Ros1	1	0.00	0.55	0.18	5.00
24	INT215287	Siglec1 Regulation of Ros1	1	0.00	0.55	0.18	5.00
25	INT215291	Siglec1 Regulation of Positive_regulation of Ros1	1	0.00	0.55	0.18	5.00
26	INT215270	Binding of Ncf1 and Ncf4	1	0.05	0.38	0.17	5.00
27	INT215269	Binding of Ncf2 and Ncf4	1	0.02	0.38	0.17	5.00
28	INT307627	Binding of BMP1 and CSF2	1	0.01	0.33	0.12	5.00
29	INT215283	Tlr4 Positive_regulation of Localization of Ncf1	2	0.05	1.04	0.11	5.00
30	INT219661	Binding of CYP2D6 and CYP2E1	1	0.30	0.22	0.08	5.00
31	INT215284	Siglec1 Negative_regulation of Binding of Mpz	1	0.01	0.63	0.08	5.00
32	INT215276	Gene_expression of Mpz Positive_regulation of Gene_expression of Ros1	1	0.01	0.4	0.05	5.00
33	INT215281	Mpz Positive_regulation of Gene_expression of Ros1	2	0.01	1.01	0.05	5.00
34	INT215288	Gene_expression of Tlr4 Positive_regulation of Gene_expression of Ros1	1	0.01	0.4	0.05	5.00
35	INT215277	Siglec1 Negative_regulation of Gene_expression of Mpz	1	0.02	0.48	0.03	5.00
36	INT215272	Siglec1 Regulation of Mpz	1	0.01	0.67	0.03	5.00
37	INT215285	Siglec1 Negative_regulation of Positive_regulation of Ros1	1	0.00	0.48	0.03	5.00
38	INT210417	APOB Negative_regulation of CYP2D6	1	0.01	0	0	5.00
39	INT210416	ITGA4 Negative_regulation of CYP2D6	1	0.01	0	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for dextromethorphan. They are ordered first by their pain relevance and then by number of times they were reported in dextromethorphan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT79620	Positive_regulation of DEM1	1	0.20	0.43	1.16	100.00
2	INT136964	Gene_expression of Dmp1	10	0.75	3.69	2.83	100.00
3	INT79621	Regulation of DEM1	1	0.08	0.2	0.79	100.00
4	INT79619	Regulation of Gene_expression of TP53INP2	2	0.15	0.41	1	100.00
5	INT50403	Negative_regulation of CYP2C19	55	0.59	8.97	17.79	100.00
6	INT21662	Gene_expression of Cpz	4	0.51	1.14	3.36	100.00
7	INT61664	Regulation of GRIN1	38	0.60	16.45	25.35	100.00
8	INT76217	Gene_expression of Spdef	13	0.62	4.86	2.32	100.00
9	INT153881	Regulation of Gene_expression of Spdef	3	0.07	0	0.5	100.00
10	INT153882	Regulation of Spdef	3	0.07	0	0.5	100.00
11	INT10120	Negative_regulation of Positive_regulation of Pdyn	14	0.58	6.05	10.19	99.98
12	INT5598	Negative_regulation of Pdyn	95	0.59	14.4	55.43	99.98
13	INT1395	Negative_regulation of Penk	537	0.59	87.33	389.81	99.98
14	INT56870	Gene_expression of CYP2D6	87	0.78	8.83	37.53	99.88
15	INT124093	Negative_regulation of Gene_expression of Gadd45a	2	0.35	1.52	0.71	99.88
16	INT68347	Negative_regulation of Cyp2d4	34	0.58	7.62	18.35	99.86
17	INT9658	Negative_regulation of Gene_expression of Il6	110	0.59	66.29	32.58	99.84
18	INT9659	Gene_expression of Il6	991	0.78	715.11	265.57	99.84
19	INT6056	Negative_regulation of Gene_expression of Fos	601	0.59	193.05	386.84	99.84
20	INT53015	Gene_expression of TP53INP2	50	0.78	9.05	26.23	99.82
21	INT15913	Negative_regulation of CYP2D6	174	0.59	22.45	70.91	99.80
22	INT180534	Gene_expression of SARS	40	0.59	35.47	0.81	99.80
23	INT2040	Positive_regulation of CYP2B6	95	0.69	34.3	25.6	99.78
24	INT5561	Negative_regulation of GRIN2D	10	0.50	2.46	4.88	99.78
25	INT8766	Positive_regulation of Positive_regulation of CYP2B6	5	0.49	3.41	1.97	99.78
26	INT18513	Binding of GRIN1	32	0.47	9.44	15.08	99.70
27	INT24527	Negative_regulation of Gal	12	0.59	7.16	6.29	99.68
28	INT124091	Negative_regulation of Gene_expression of Myo1b	1	0.04	1.08	0.8	99.68
29	INT117143	Negative_regulation of Gene_expression of Cxcr1	4	0.33	5.35	2.78	99.68
30	INT117147	Negative_regulation of Gene_expression of Cxcl2	19	0.55	15.33	6.57	99.68
31	INT90091	Gene_expression of GOPC	967	0.67	366.22	103.6	99.68
32	INT720	Positive_regulation of POMC	807	0.70	237.37	353.83	99.66
33	INT118565	Gene_expression of Ddit3	35	0.75	23.62	4.32	99.60
34	INT124090	Gene_expression of Gadd45a	9	0.63	3.25	0.99	99.60
35	INT93240	Gene_expression of Pgpep1	7	0.59	1.69	0.44	99.58
36	INT17862	Localization of Cyp1a1	5	0.74	0.34	1.34	99.56
37	INT55418	Regulation of CYP2D6	29	0.61	1.83	10.21	99.56
38	INT303913	Regulation of Regulation of CYP2D6	2	0.37	1.09	1.48	99.56
39	INT728	Positive_regulation of Penk	1068	0.70	186.9	636.87	99.54
40	INT62725	Regulation of GRIN2D	6	0.45	2.98	5.68	99.52
41	INT91913	Regulation of GRIN3B	16	0.61	11.48	14.44	99.52
42	INT10797	Binding of CYP2D6	86	0.48	15.09	31.16	99.44
43	INT32576	Positive_regulation of Npap60	1	0.38	0.34	0.58	99.44
44	INT124092	Gene_expression of Myo1b	3	0.41	1.22	0.82	99.38
45	INT117142	Gene_expression of Thbs1	58	0.72	45.02	6.51	99.38
46	INT83950	Gene_expression of Cxcr1	31	0.59	27.76	13.91	99.38
47	INT83953	Gene_expression of Cxcl2	140	0.75	113.07	43.65	99.38
48	INT23952	Gene_expression of Cyp2d4	18	0.78	4.76	5.31	99.38
49	INT5595	Positive_regulation of Pdyn	223	0.70	48.37	130.14	99.36
50	INT4403	Binding of CYP2B6	113	0.48	21.17	33.83	99.28
51	INT50404	Negative_regulation of CYP1A2	49	0.59	8.61	17.35	99.20
52	INT65102	Regulation of Ntf4	3	0.43	0.05	3.42	99.20
53	INT181636	Positive_regulation of Gene_expression of BMP1	2	0.44	4.46	0.68	99.16
54	INT50405	Negative_regulation of CYP3A4	238	0.59	53.65	51.51	99.04
55	INT59929	Negative_regulation of CYP2C9	60	0.59	16.33	15.39	99.04
56	INT101342	Negative_regulation of CYP2A6	11	0.53	3.68	2.39	99.04
57	INT12231	Positive_regulation of Localization of Nts	17	0.70	4.54	13.85	98.90
58	INT47710	Negative_regulation of GRIN1	71	0.57	25.57	34.24	98.84
59	INT47848	Negative_regulation of Positive_regulation of FOS	14	0.57	3.78	7.63	98.84
60	INT60995	Negative_regulation of Positive_regulation of Homer1	9	0.38	1.63	9.63	98.82
61	INT54785	Binding of LOC502940	2	0.18	0.07	0.52	98.76
62	INT719	Negative_regulation of SGCG	96	0.57	47.91	30.22	98.72
63	INT22557	Gene_expression of BMP1	3	0.59	20.18	4.73	98.64
64	INT8363	Localization of Nts	135	0.81	14.29	61.71	98.62
65	INT79622	Negative_regulation of Binding of TP53INP2	2	0.14	0.43	1.83	98.60
66	INT76701	Binding of TP53INP2	13	0.31	0.55	8.13	98.60
67	INT5356	Positive_regulation of FOS	153	0.69	54.21	56.74	98.54
68	INT105754	Regulation of St13	8	0.28	0.75	11.41	98.38
69	INT60188	Positive_regulation of Cyp2d4	10	0.70	1.04	4.35	98.36
70	INT47818	Positive_regulation of Homer1	48	0.70	11.11	24.05	98.36
71	INT5200	Gene_expression of Fos	3083	0.78	894.43	1639.02	98.28
72	INT6176	Positive_regulation of Htr1a	117	0.67	28.23	66.17	98.14
73	INT25198	Regulation of Pkia	3	0.27	0.51	3.31	97.76
74	INT797	Regulation of Penk	812	0.62	111.13	542.24	97.52
75	INT5594	Regulation of Pdyn	137	0.62	27.04	86.63	97.52
76	INT5202	Positive_regulation of Gene_expression of Fos	1163	0.70	319.28	684	97.32
77	INT145786	Binding of WWOX	2	0.35	0.59	0.55	97.16
78	INT58852	Positive_regulation of Enc1	20	0.49	7.51	13.25	96.96
79	INT65881	Gene_expression of CYP2C19	21	0.76	1.19	4.57	96.96
80	INT16131	Negative_regulation of GBE1	37	0.30	10.32	8.15	96.84
81	INT9027	Positive_regulation of Ddc	24	0.66	6.04	10.19	96.80
82	INT12129	Gene_expression of CYP3A4	107	0.78	23.11	27.6	96.60
83	INT70878	Gene_expression of CYP2A6	17	0.75	4.25	2.02	96.60
84	INT79780	Gene_expression of Cyp4a3	14	0.56	5.19	1.12	96.60
85	INT10796	Gene_expression of CYP2B6	131	0.77	30.14	35.27	96.08
86	INT51722	Positive_regulation of Localization of HELLS	1	0.05	0.37	0.76	96.08
87	INT4941	Positive_regulation of Oprd1	345	0.70	74.26	304.41	95.84
88	INT7114	Positive_regulation of Ltp	1192	0.62	290.76	755.77	95.68
89	INT7627	Negative_regulation of Positive_regulation of Ltp	162	0.50	41.2	106.27	95.68
90	INT36517	Negative_regulation of MCF2	14	0.42	6.43	1.02	95.60
91	INT51724	Localization of HELLS	2	0.49	1.02	0.81	95.52
92	INT92514	Regulation of Grin2b	22	0.50	11.07	16.92	95.52
93	INT347186	Regulation of Negative_regulation of Cyp2d4	1	0.45	0.21	0.25	95.36
94	INT144738	Regulation of Gene_expression of CYP2D6	3	0.60	0	1.44	95.28
95	INT217252	Regulation of Gene_expression of SARS	1	0.26	0	0.05	95.28
96	INT22897	Positive_regulation of Tmprss11d	1	0.49	0.4	1.07	94.94
97	INT12837	Binding of SIGMAR1	57	0.48	5.31	15.49	94.32
98	INT22210	Gene_expression of CYP1A2	45	0.78	4.95	10.66	93.80
99	INT65880	Gene_expression of CYP2C8	25	0.77	9.49	1.92	93.80
100	INT103553	Positive_regulation of Positive_regulation of MTX1	1	0.01	0.53	0.69	93.44
101	INT4803	Transcription of Penk	435	0.72	59.09	182.4	93.12
102	INT110551	Negative_regulation of Negative_regulation of CYP2D6	3	0.40	0.25	1.38	93.08
103	INT88790	Negative_regulation of Gene_expression of Dlg4	6	0.59	1.53	4.66	93.00
104	INT6826	Transcription of Pdyn	130	0.71	22.19	54.88	92.72
105	INT51723	Regulation of HELLS	2	0.30	1.03	0.75	92.72
106	INT14126	Gene_expression of Grina	13	0.67	4.63	4.57	92.68
107	INT88789	Gene_expression of Dlg4	26	0.78	4.41	12.74	92.52
108	INT89701	Binding of CYP2A6	4	0.36	0.92	2.23	92.52
109	INT103554	Positive_regulation of MTX1	19	0.45	11.23	10	92.48
110	INT57922	Gene_expression of CYP2C9	65	0.78	22.24	7.53	92.28
111	INT9904	Gene_expression of CYP2E1	64	0.78	13.11	14.65	92.28
112	INT22212	Gene_expression of CYP1A1	34	0.76	10.11	2.77	92.28
113	INT74098	Negative_regulation of Gene_expression of Nos1	36	0.59	16.25	14.82	92.04
114	INT115938	Negative_regulation of Negative_regulation of Nos1	2	0.36	0.27	1.31	92.04
115	INT134879	Negative_regulation of Phosphorylation of Nos1	1	0.50	0.27	0.93	92.04
116	INT134878	Negative_regulation of Negative_regulation of Dlg4	1	0.35	0.27	0.93	92.04
117	INT169987	Transcription of GOPC	45	0.60	21.88	2.61	91.76
118	INT170604	Negative_regulation of Gene_expression of GOPC	50	0.35	12.71	4.51	91.60
119	INT11013	Negative_regulation of Phosphorylation of Creb1	55	0.59	18.74	34.66	91.48
120	INT64558	Negative_regulation of Nos1	88	0.58	26.76	36.78	91.48
121	INT97100	Negative_regulation of Dlg4	16	0.58	6.18	14.36	91.48
122	INT134876	Negative_regulation of Phosphorylation of Dlg4	1	0.35	0.27	0.93	91.48
123	INT145488	Regulation of Cyp2d4	5	0.45	1.1	1.19	91.16
124	INT5567	Positive_regulation of Pkia	12	0.69	1.67	14.1	91.04
125	INT21254	Regulation of Positive_regulation of POMC	12	0.61	3.64	4.67	90.96
126	INT1931	Positive_regulation of Gene_expression of POMC	116	0.70	37.26	38.67	90.96
127	INT467	Gene_expression of POMC	1048	0.78	332.8	394.16	90.96
128	INT134873	Phosphorylation of Dlg4	3	0.80	0.5	1.42	90.96
129	INT134875	Phosphorylation of Nos1	5	0.70	1.21	3.44	90.64
130	INT74058	Gene_expression of Nos1	260	0.78	80.04	95.71	90.64
131	INT12634	Gene_expression of Pkia	3	0.55	0.38	5	90.64
132	INT282596	Localization of BMP1	2	0.61	4.04	1.97	90.64
133	INT307635	Positive_regulation of Localization of BMP1	1	0.38	1.35	0.36	90.64
134	INT307630	Negative_regulation of Localization of BMP1	1	0.32	1.41	0.21	90.64
135	INT60145	Regulation of Negative_regulation of Ltp	4	0.23	1.82	4.09	90.44
136	INT11009	Phosphorylation of Creb1	458	0.82	111.34	221.97	90.24
137	INT92518	Gene_expression of Grin2b	131	0.78	65.52	80.91	90.00
138	INT307631	Positive_regulation of Binding of BMP1	1	0.38	2.99	0.24	90.00
139	INT135520	Positive_regulation of KCNJ9	2	0.07	0.18	1.91	89.92
140	INT7506	Negative_regulation of Ltp	267	0.46	91.01	176.8	89.88
141	INT22898	Negative_regulation of Gls	2	0.45	1.52	3.19	89.84
142	INT67912	Gene_expression of GRIN1	75	0.77	28.99	29.28	89.68
143	INT49651	Gene_expression of Creb1	276	0.78	114.77	111.96	89.48
144	INT50580	Binding of PPIG	39	0.36	11.17	12.34	88.96
145	INT50581	Regulation of PPIG	26	0.55	8.96	4.32	88.96
146	INT93575	Regulation of Binding of PPIG	1	0.44	0.15	0.18	88.96
147	INT143686	Negative_regulation of Gene_expression of CYP2D6	4	0.58	0.83	2.16	88.60
148	INT2802	Negative_regulation of Asrgl1	14	0.59	2.69	7.37	88.56
149	INT113876	Negative_regulation of Phosphorylation of Creb3	2	0.17	0.81	2.18	88.24
150	INT6177	Binding of Htr1a	65	0.47	17.65	30.59	88.12
151	INT30160	Positive_regulation of ADRA2B	14	0.29	1.92	4.37	87.60
152	INT134877	Gene_expression of Creb3	2	0.18	0.31	1.39	87.40
153	INT7093	Negative_regulation of CYP2B6	146	0.58	37.3	48.39	87.36
154	INT118702	Regulation of Ncs1	2	0.53	1.59	0.47	87.20
155	INT2085	Positive_regulation of LH	441	0.70	60.15	191.02	87.12
156	INT63057	Regulation of CYP3A4	31	0.61	5.75	6.92	86.96
157	INT93451	Positive_regulation of Gene_expression of Grin2b	43	0.70	29.09	31.89	86.64
158	INT57923	Gene_expression of CYP3A	12	0.71	2.62	2	86.44
159	INT134825	Gene_expression of Cyp2d22	1	0.62	0.18	0.86	86.32
160	INT113878	Phosphorylation of Creb3	4	0.24	1.12	3.43	86.32
161	INT134826	Positive_regulation of Gene_expression of Cyp2d22	1	0.37	0.1	0.31	86.32
162	INT19109	Positive_regulation of CYP3A5	7	0.67	1.48	1.51	85.60
163	INT7341	Positive_regulation of Grin1	169	0.70	65.86	118.38	83.84
164	INT76024	Negative_regulation of Cyp3a11	7	0.53	2.96	3.16	82.88
165	INT14049	Positive_regulation of GRIN1	102	0.70	48.31	71.06	82.84
166	INT65514	Gene_expression of Cyp1a2	25	0.77	6.12	4.6	82.56
167	INT90960	Positive_regulation of Gene_expression of CYP2D6	9	0.50	2.06	2.76	82.28
168	INT12838	Gene_expression of SIGMAR1	30	0.78	3.52	6.81	82.24
169	INT3920	Localization of Ldha	241	0.81	83.08	58.72	81.88
170	INT20003	Gene_expression of Scn2a1	125	0.71	8.78	23.94	81.08
171	INT13338	Regulation of Sigmar1	22	0.57	2.91	11.35	81.00
172	INT48766	Regulation of NOS1	73	0.61	37.01	24.59	80.20
173	INT120807	Binding of NOL3	10	0.45	3.62	3.97	79.84
174	INT134874	Regulation of Dlg4	3	0.58	0.28	2.12	79.76
175	INT19408	Negative_regulation of Cyp2c22	37	0.59	6.23	14.22	79.52
176	INT12501	Positive_regulation of Adarb1	166	0.58	36.94	118.92	79.48
177	INT29020	Positive_regulation of pcp	18	0.45	3.5	6.39	78.96
178	INT163516	Negative_regulation of Positive_regulation of PRB1	1	0.15	0.08	0.45	77.76
179	INT6762	Binding of Srms	56	0.31	6.62	30.27	75.92
180	INT307634	Binding of BMP1	1	0.36	3.12	3.26	75.20
181	INT307632	Regulation of Binding of BMP1	1	0.34	1.53	0.12	75.20
182	INT59041	Negative_regulation of CYP2E1	17	0.59	5.47	4.51	75.00
183	INT82072	Positive_regulation of Ntf4	5	0.41	1.05	2.49	75.00
184	INT21661	Regulation of Negative_regulation of Gls2	1	0.02	0.26	0.6	75.00
185	INT21664	Negative_regulation of Gls2	1	0.02	0.26	0.6	75.00
186	INT21663	Regulation of Negative_regulation of Asrgl1	1	0.03	0.21	0.6	75.00
187	INT4637	Binding of Adarb1	132	0.41	14.48	67.76	75.00
188	INT6431	Positive_regulation of Ass1	36	0.24	8.08	10.43	75.00
189	INT45112	Positive_regulation of PRB1	20	0.60	6.49	2.85	73.76
190	INT117204	Gene_expression of Tcm	39	0.58	10.58	4.88	72.96
191	INT70877	Gene_expression of PPIG	72	0.75	22.39	10.93	72.92
192	INT6855	Binding of NCOR2	71	0.41	15.64	28.96	72.56
193	INT20336	Positive_regulation of CYP2E1	48	0.70	19.26	15.66	72.44
194	INT61599	Positive_regulation of CYP2C9	43	0.69	11.1	8.33	72.16
195	INT12334	Positive_regulation of CYP3A	34	0.70	6.77	7.85	71.44
196	INT262375	Binding of Fmod	1	0.20	12.37	10.1	71.36
197	INT68559	Negative_regulation of Gli3	5	0.37	4.56	4.93	71.12
198	INT93241	Positive_regulation of Pgpep1	1	0.05	0	0.32	70.80
199	INT10798	Positive_regulation of CYP2D6	24	0.56	5.82	11.31	70.36
200	INT94029	Positive_regulation of Grin2b	58	0.70	24.2	42.52	69.92