P:sNRI

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Pain Term
Category Drug class
Synonyms SerotoninÐnorepinephrine Reuptake Inhibitor, SerotoninÐnorepinephrine Reuptake Inhibitors, SNRIs
Pain Specific No
Documents 216
Hot Single Events 62
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for sNRI. They are ordered first by their pain relevance and then by number of times they were reported for sNRI. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT333549 Binding of CTLA4 and PDCD1 1 0.36 1.2 0.27 76.16
2 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 67.56
3 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08 57.12
4 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 18.56
5 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 18.20
6 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25 5.00
7 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27 5.00
8 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26 5.00
9 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
10 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
11 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48 5.00
12 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
13 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 5.00
14 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2 5.00
15 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19 5.00
16 INT321478 Binding of Slc6a2 and Flvcr2 1 0.00 0.41 1.14 5.00
17 INT321476 Binding of Slc6a3 and Slc6a2 1 0.01 0.41 1.14 5.00
18 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13 5.00
19 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 5.00
20 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81 5.00
21 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74 5.00
22 INT321479 Ubqln1 Regulation of Cfp 1 0.00 0.37 0.67 5.00
23 INT271194 Binding of Bdnf and Gopc 1 0.03 0.49 0.6 5.00
24 INT271192 Binding of Gopc and Gtf3a 1 0.00 0.49 0.6 5.00
25 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
26 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
27 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52 5.00
28 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52 5.00
29 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51 5.00
30 INT218783 Binding of Faah and Cfp 1 0.04 0.55 0.45 5.00
31 INT327562 Binding of MCS and AKR1B10 1 0.00 0.5 0.41 5.00
32 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 5.00
33 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 5.00
34 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11 5.00
35 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07 5.00
36 INT272977 Osr1 Regulation of ADHD1 1 0.01 1.79 0 5.00
37 INT272978 Binding of Osr1 and ADHD1 1 0.00 1.91 0 5.00
38 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for sNRI. They are ordered first by their pain relevance and then by number of times they were reported in sNRI. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT123705 Gene_expression of SMARCB1 40 0.73 19.47 2.2 100.00
2 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 100.00
3 INT156326 Positive_regulation of SMARCB1 20 0.67 8.77 0.97 100.00
4 INT123704 Binding of SMARCB1 12 0.36 5.49 0.61 100.00
5 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 99.86
6 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 99.66
7 INT81388 Localization of Xpr1 6 0.55 2.26 2.09 99.54
8 INT91475 Binding of NDOR1 3 0.27 0.61 4.97 98.76
9 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12 98.68
10 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 98.24
11 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 97.32
12 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 96.24
13 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 96.04
14 INT65515 Binding of ocd 7 0.36 6.62 1.48 95.92
15 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 95.76
16 INT214 Localization of AVP 370 0.81 208.51 91.09 95.64
17 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 95.48
18 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16 95.44
19 INT812 Localization of INS 1026 0.81 515.6 145.31 95.36
20 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 95.28
21 INT6228 Localization of Htr1a 14 0.78 0.46 6.2 95.04
22 INT72322 Positive_regulation of Localization of Htr1a 5 0.49 0 3.08 95.04
23 INT242353 Binding of Tcas1 3 0.03 3.31 2.22 94.96
24 INT185518 Gene_expression of Vms1 2 0.22 2.16 0.25 93.48
25 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 92.72
26 INT93354 Negative_regulation of Slc16a11 2 0.51 1.59 2.53 91.88
27 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92 91.56
28 INT146119 Regulation of Sri 1 0.23 0.26 0.53 90.96
29 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 90.12
30 INT4012 Negative_regulation of Psd 23 0.52 14.12 3.81 90.04
31 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01 90.00
32 INT169173 Gene_expression of ocd 9 0.50 4.49 1.28 89.52
33 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 89.08
34 INT76374 Negative_regulation of Binding of Flvcr2 4 0.35 0.4 2.46 87.92
35 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 87.92
36 INT99116 Binding of Cacna2d3 15 0.48 7.33 13.58 87.80
37 INT55185 Binding of Sert1 26 0.48 4.43 7.57 87.60
38 INT75709 Regulation of Regulation of Slc6a2 1 0.01 0.48 0.57 86.28
39 INT203050 Binding of PDCD1 12 0.48 12.93 4.5 86.00
40 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 86.00
41 INT29086 Negative_regulation of Sert1 37 0.58 7.49 14.98 85.72
42 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 85.68
43 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 85.68
44 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 85.60
45 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 85.20
46 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 85.20
47 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03 85.16
48 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 85.12
49 INT104007 Negative_regulation of Positive_regulation of GRIN1 2 0.15 1.5 0.88 85.12
50 INT75169 Positive_regulation of GGT2 2 0.67 1.87 0.18 84.80
51 INT6791 Binding of NA 55 0.46 5.36 17.59 84.76
52 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 84.48
53 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 84.04
54 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 83.76
55 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 83.60
56 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79 83.52
57 INT27785 Regulation of HTR2A 11 0.44 8 8.18 82.00
58 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81 82.00
59 INT4562 Regulation of Slc6a2 8 0.53 1.45 3.43 81.96
60 INT288087 Regulation of Gene_expression of ECT 1 0.05 0.3 0.7 81.72
61 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 81.00
62 INT320137 Binding of Dvs1 1 0.01 0.34 0.18 80.60
63 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 79.08
64 INT2415 Binding of MAOA 26 0.47 13.26 11.86 76.20
65 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 76.16
66 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 76.00
67 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 75.16
68 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49 74.96
69 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 73.60
70 INT181587 Negative_regulation of OPN1SW 12 0.51 4.36 0.89 73.36
71 INT250978 Binding of FMOD 4 0.16 12.32 8.75 73.00
72 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 72.28
73 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 71.36
74 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28 70.48
75 INT348 Regulation of Adra1a 25 0.45 3.33 10.27 69.60
76 INT262375 Binding of Fmod 1 0.20 12.37 10.1 69.60
77 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 68.64
78 INT32793 Negative_regulation of Slc6a2 12 0.44 1.8 5.78 68.56
79 INT29368 Binding of ECT 25 0.41 11.65 5.81 67.80
80 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 67.40
81 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 66.40
82 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72 66.40
83 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 63.52
84 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 63.04
85 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 62.56
86 INT19488 Localization of ABAT 56 0.69 21.51 50.56 61.08
87 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 61.04
88 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 61.00
89 INT264577 Positive_regulation of Gene_expression of ATF7IP 2 0.17 0.68 0.19 60.68
90 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 60.44
91 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 60.32
92 INT26863 Regulation of Vms1 7 0.09 2.67 2.23 60.08
93 INT50580 Binding of PPIG 39 0.36 11.17 12.34 59.44
94 INT179857 Gene_expression of ATF7IP 14 0.65 4.12 0.89 59.36
95 INT320136 Gene_expression of Dvs1 1 0.01 0.45 0.29 58.24
96 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 58.08
97 INT105746 Regulation of ECT 22 0.39 7.6 7.47 57.92
98 INT18543 Negative_regulation of ECT 20 0.37 8.4 5.25 57.92
99 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 57.44
100 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 57.20
101 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 56.56
102 INT235710 Binding of SSR1 2 0.36 0.86 1.75 56.16
103 INT199570 Negative_regulation of Tks 7 0.26 4.41 0.59 55.44
104 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 54.96
105 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 54.88
106 INT203049 Negative_regulation of PDCD1 6 0.43 7.15 2.36 54.88
107 INT78487 Localization of SSR1 2 0.73 0.95 1.7 53.68
108 INT134346 Binding of PCS 51 0.37 22.27 5.67 50.48
109 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 47.84
110 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 47.12
111 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 46.16
112 INT261979 Positive_regulation of PDCD1 4 0.49 6.95 0.61 45.44
113 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64 45.20
114 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 45.00
115 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 45.00
116 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 45.00
117 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 45.00
118 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29 45.00
119 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 45.00
120 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 43.96
121 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 43.56
122 INT133906 Positive_regulation of Gene_expression of Ncam1 6 0.70 1.9 2 42.00
123 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62 41.44
124 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48 39.84
125 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 39.40
126 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 38.28
127 INT293386 Regulation of Positive_regulation of NDOR1 1 0.03 0 0.33 36.28
128 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 36.16
129 INT91476 Positive_regulation of NDOR1 3 0.50 1.07 1 35.72
130 INT123787 Gene_expression of Bid 25 0.66 16 6.35 34.80
131 INT30693 Binding of Ggt1 3 0.36 1.76 0.33 33.92
132 INT48308 Binding of PLP1 7 0.48 9.59 6.09 33.28
133 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 33.16
134 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 30.20
135 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 29.92
136 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 29.32
137 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69 28.56
138 INT54602 Regulation of MCS 22 0.24 10.41 5.75 28.16
139 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 27.84
140 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 26.96
141 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 26.56
142 INT139236 Regulation of Sgk1 2 0.37 0.84 1.14 25.00
143 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 24.88
144 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 24.12
145 INT546 Binding of ALB 311 0.48 85.98 60.14 23.80
146 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 23.68
147 INT35366 Binding of AR 87 0.47 30.52 8.9 22.36
148 INT124938 Gene_expression of MTNR1B 15 0.15 3.63 1.72 22.16
149 INT11107 Binding of Lbp 12 0.42 4.42 3.41 21.84
150 INT189169 Positive_regulation of MTNR1B 10 0.16 3.71 1.61 21.76
151 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 21.20
152 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 21.12
153 INT118124 Binding of USE1 24 0.16 16.64 5.44 21.12
154 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17 19.28
155 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 17.44
156 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 17.44
157 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 16.88
158 INT204929 Binding of IL33 18 0.08 4.74 0.7 16.88
159 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 15.80
160 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 15.32
161 INT234 Binding of Alb 151 0.48 52.34 32.97 14.48
162 INT22540 Negative_regulation of Binding of Alb 8 0.59 0.56 1.34 14.48
163 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 14.20
164 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28 14.16
165 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 14.08
166 INT243845 Localization of MAOA 4 0.55 1.52 0.77 14.08
167 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 13.72
168 INT90082 Positive_regulation of Degs1 2 0.04 6.09 1.9 13.32
169 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 13.28
170 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 11.60
171 INT170746 Regulation of REM1 3 0.20 1.3 0.56 10.96
172 INT2396 Regulation of Maoa 25 0.62 6.04 13.27 10.48
173 INT5205 Localization of AR 43 0.80 12.87 4.63 10.44
174 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43 10.32
175 INT251516 Regulation of Gene_expression of REM1 4 0.20 1.81 0.95 10.32
176 INT251 Regulation of INS 398 0.62 232.47 55.04 9.60
177 INT273000 Localization of IL33 5 0.45 1.77 0.56 9.32
178 INT134315 Gene_expression of RT1-Hb-ps1 3 0.35 3.35 1.34 9.12
179 INT295414 Negative_regulation of Gene_expression of RT1-Hb-ps1 1 0.08 1.65 0.7 9.12
180 INT255001 Negative_regulation of RT1-Hb-ps1 9 0.11 12.94 3.09 8.56
181 INT185519 Binding of Vms1 5 0.12 4.58 1.37 8.44
182 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87 5.96
183 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
184 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
185 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
186 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
187 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
188 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
189 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
190 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
191 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
192 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
193 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
194 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 5.00
195 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
196 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
197 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
198 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
199 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
200 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
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