P:tramadol

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 1975
Hot Single Events 200
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for tramadol. They are ordered first by their pain relevance and then by number of times they were reported for tramadol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5 99.02
2 INT66428 Dcc Positive_regulation of Fos 2 0.05 0.39 1.29 92.32
3 INT130222 IL2 Positive_regulation of Il2rb 1 0.00 0 0 50.00
4 INT223283 Binding of CYP2C9 and VKORC1 1 0.31 0.16 0 39.04
5 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 37.44
6 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5 5.00
7 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
8 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 5.00
9 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
10 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16 5.00
11 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02 5.00
12 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94 5.00
13 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84 5.00
14 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83 5.00
15 INT299987 SPANXB1 Positive_regulation of TRPV1 1 0.20 0.71 0.82 5.00
16 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67 5.00
17 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
18 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
19 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00
20 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 5.00
21 INT309003 Ins1 Positive_regulation of TNF 1 0.05 1.74 0.35 5.00
22 INT227339 Binding of TNF and Ins1 1 0.28 4.08 0.31 5.00
23 INT309000 Ins1 Positive_regulation of Gene_expression of Mmp9 1 0.20 1.03 0.22 5.00
24 INT309002 Ins1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.22 5.00
25 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
26 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
27 INT232592 Binding of Csf2 and Gtf3a 1 0.02 0.47 0.14 5.00
28 INT323640 Vcam1 Positive_regulation of Gene_expression of Icam1 1 0.42 1.75 0.08 5.00
29 INT232590 Csf2 Positive_regulation of Serpina5 1 0.17 0.65 0.05 5.00
30 INT232591 Binding of Csf2 and Wbc1 1 0.06 0.47 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for tramadol. They are ordered first by their pain relevance and then by number of times they were reported in tramadol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT20462 Binding of ESR1 210 0.44 102.7 26.34 100.00
2 INT92354 Localization of ESR1 77 0.75 33.04 15.51 100.00
3 INT10116 Localization of INSR 11 0.57 5.43 3.48 100.00
4 INT50313 Negative_regulation of Positive_regulation of htr 9 0.51 0.09 5.63 100.00
5 INT83035 Binding of INSR 16 0.47 9.29 4.11 100.00
6 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73 100.00
7 INT10706 Regulation of Il6 150 0.62 93.23 62.34 100.00
8 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74 100.00
9 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 100.00
10 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 100.00
11 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 100.00
12 INT15796 Regulation of IL2 66 0.61 25.43 20.62 100.00
13 INT4728 Negative_regulation of Positive_regulation of PPT1 2 0.42 0.29 3.07 100.00
14 INT23126 Regulation of HTR3A 10 0.60 5.42 4.81 100.00
15 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 100.00
16 INT63390 Regulation of Gene_expression of SGCG 2 0.44 0.69 1.21 100.00
17 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 100.00
18 INT126500 Regulation of Gene_expression of GRIN1 2 0.44 0.12 2.01 100.00
19 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 100.00
20 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 100.00
21 INT3013 Binding of trm 3 0.47 1.32 1.27 100.00
22 INT108415 Negative_regulation of Regulation of htr 1 0.23 0 1.33 100.00
23 INT57673 Regulation of Positive_regulation of htr 2 0.24 0.27 1.76 100.00
24 INT57672 Regulation of htr 2 0.15 0.16 1.68 100.00
25 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 100.00
26 INT232644 Transcription of IER3 1 0.01 0.97 1.58 100.00
27 INT232645 Transcription of INSR 2 0.09 1.19 1.71 100.00
28 INT987 Localization of TRH 37 0.78 10.53 11.1 100.00
29 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
30 INT158453 Negative_regulation of TRAM1 1 0.36 0 0.92 100.00
31 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09 100.00
32 INT76728 Binding of Vkorc1 1 0.01 0.1 0.36 100.00
33 INT133057 Binding of TRAM1 8 0.41 1.62 0.64 100.00
34 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 100.00
35 INT29622 Regulation of Git1 4 0.61 0.1 1.87 100.00
36 INT36969 Regulation of Ginf1 2 0.06 0.27 0.82 100.00
37 INT168720 Regulation of Negative_regulation of Rock1 1 0.43 1.31 1.23 100.00
38 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 100.00
39 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 100.00
40 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34 100.00
41 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 99.98
42 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 99.98
43 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 99.98
44 INT50314 Negative_regulation of htr 13 0.51 0.19 6.2 99.98
45 INT21606 Positive_regulation of Regulation of Ins1 8 0.41 3.9 2.97 99.98
46 INT45553 Negative_regulation of PCK1 3 0.43 0.73 1.17 99.98
47 INT99530 Negative_regulation of Gene_expression of PCK1 1 0.05 0.54 1.17 99.98
48 INT99533 Negative_regulation of Positive_regulation of PCK1 1 0.05 0.54 1.17 99.98
49 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 99.98
50 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 99.98
51 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 99.98
52 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 99.96
53 INT15489 Negative_regulation of Gene_expression of SGCG 10 0.42 4.78 3.18 99.96
54 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 99.96
55 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.92
56 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 99.92
57 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 99.92
58 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 99.92
59 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.90
60 INT10344 Localization of Jun 23 0.73 6.36 7.46 99.90
61 INT50315 Positive_regulation of htr 20 0.61 1.96 11.22 99.84
62 INT158452 Negative_regulation of GIT1 3 0.22 1.16 2.13 99.84
63 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28 99.82
64 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 99.82
65 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 99.80
66 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.80
67 INT158454 Negative_regulation of Negative_regulation of GIT1 1 0.08 0 1.1 99.80
68 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43 99.76
69 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 99.76
70 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 99.76
71 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78 99.76
72 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 99.76
73 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34 99.72
74 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84 99.72
75 INT99532 Positive_regulation of PCK1 2 0.25 1.19 1.25 99.72
76 INT99531 Positive_regulation of Gene_expression of PCK1 1 0.05 0.54 1.16 99.72
77 INT4729 Positive_regulation of PPT1 19 0.67 7.11 17.83 99.68
78 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 99.68
79 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.68
80 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 99.66
81 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 99.64
82 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 99.64
83 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.62
84 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 99.60
85 INT81195 Binding of Bcmo1 17 0.33 1.28 2.45 99.58
86 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 99.58
87 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 99.56
88 INT14114 Binding of Adra2a 30 0.48 4.24 18.53 99.54
89 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 99.52
90 INT65277 Negative_regulation of Fst 20 0.43 4.61 11.83 99.50
91 INT3301 Positive_regulation of Slc43a3 26 0.55 5.48 10.81 99.50
92 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 99.50
93 INT112233 Binding of NDC80 2 0.01 2.44 0.57 99.50
94 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 99.48
95 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 99.48
96 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 99.44
97 INT29228 Negative_regulation of Binding of NCOR2 4 0.02 0.62 2.47 99.42
98 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78 99.36
99 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.30
100 INT9011 Negative_regulation of Nrtim1 15 0.30 2.35 12.58 99.28
101 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.26
102 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 99.26
103 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75 99.24
104 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25 99.24
105 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 99.24
106 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59 99.24
107 INT47687 Positive_regulation of Transcription of Ntrk2 5 0.45 2.42 2.24 99.24
108 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03 99.24
109 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 99.24
110 INT133736 Negative_regulation of Git1 1 0.37 0.16 0.51 99.24
111 INT98020 Gene_expression of PCK1 4 0.53 1.21 1.37 99.20
112 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 99.16
113 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 99.16
114 INT87623 Gene_expression of PPT1 9 0.75 5.32 7.65 99.12
115 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 99.12
116 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 99.12
117 INT149975 Negative_regulation of Ppif 1 0.41 0.44 2.36 99.10
118 INT87624 Positive_regulation of Gene_expression of PPT1 2 0.49 0.75 1.07 99.08
119 INT349073 Localization of ETF1 1 0.11 0 0.44 99.06
120 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 99.00
121 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6 98.98
122 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 98.98
123 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 98.96
124 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 98.96
125 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 98.88
126 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 98.88
127 INT65009 Gene_expression of HTR3A 29 0.75 8.51 10.59 98.86
128 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 98.84
129 INT126711 Gene_expression of Bcmo1 5 0.60 0.44 1.03 98.84
130 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 98.82
131 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04 98.78
132 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 98.76
133 INT70701 Binding of FCGR3A 5 0.36 1.2 0.38 98.76
134 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 98.72
135 INT10763 Localization of IL2 157 0.80 81.11 33.21 98.72
136 INT7531 Positive_regulation of Eef1a1 29 0.62 8.16 15.41 98.72
137 INT113961 Regulation of PPT1 6 0.26 3.87 6.09 98.68
138 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 98.68
139 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.68
140 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 98.64
141 INT146786 Positive_regulation of Positive_regulation of PPT1 2 0.45 0.13 0.98 98.64
142 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51 98.64
143 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 98.62
144 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 98.60
145 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47 98.52
146 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 98.50
147 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48 98.48
148 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 98.44
149 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 98.42
150 INT129604 Negative_regulation of SPINK4 4 0.51 0.68 0.43 98.40
151 INT60931 Negative_regulation of Fst 15 0.57 5.44 7.21 98.34
152 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 98.32
153 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 98.32
154 INT154455 Gene_expression of dds 4 0.58 3.84 0.46 98.30
155 INT129871 Positive_regulation of Gene_expression of Gck 1 0.28 0.15 2.19 98.28
156 INT95621 Gene_expression of Gck 6 0.64 1.06 2.26 98.28
157 INT18519 Positive_regulation of Negative_regulation of Pdyn 6 0.47 0.14 8.72 98.24
158 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 98.16
159 INT95320 Localization of Dld 3 0.32 0.49 0.75 98.16
160 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 98.16
161 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 98.08
162 INT74505 Positive_regulation of Inadl2 12 0.35 2.1 7.83 97.96
163 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 97.96
164 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 97.92
165 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 97.88
166 INT12859 Localization of Insrr 16 0.32 2.68 8.07 97.76
167 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 97.64
168 INT11807 Gene_expression of Il2 266 0.78 112 64.97 97.58
169 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 97.48
170 INT7901 Positive_regulation of Ppidl1 14 0.15 1.58 8.8 97.48
171 INT3948 Regulation of Cck 291 0.62 58.07 255.88 97.36
172 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 97.16
173 INT83407 Negative_regulation of Gucy1b2 11 0.58 0.9 4.2 97.08
174 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33 97.08
175 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 97.08
176 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41 96.96
177 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 96.84
178 INT39856 Binding of Neurod1 8 0.47 1.44 2.88 96.76
179 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 96.60
180 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63 96.00
181 INT153044 Negative_regulation of Gene_expression of Marcks 2 0.37 0 1.84 95.60
182 INT153045 Negative_regulation of Negative_regulation of Marcks 1 0.37 0 1.54 95.60
183 INT107555 Gene_expression of Marcks 8 0.58 1.22 3.56 95.60
184 INT92355 Negative_regulation of Marcks 4 0.48 0 3.07 95.60
185 INT205735 Regulation of Localization of PPT1 1 0.23 0 1.12 95.44
186 INT140822 Localization of PPT1 2 0.57 1.1 1.94 95.44
187 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 95.28
188 INT101549 Negative_regulation of EMP1 8 0.57 1.82 1.01 94.80
189 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 94.64
190 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59 94.04
191 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 93.72
192 INT16659 Gene_expression of Eef1a1 34 0.64 6.1 11.85 93.68
193 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 93.60
194 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 93.60
195 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 93.48
196 INT7474 Gene_expression of Man2a2 38 0.67 3.31 18.42 93.36
197 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 93.24
198 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98 93.24
199 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 93.24
200 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 93.12
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